Gyani Inder Singh Institute of Professional Studies

Dehradun, India

Gyani Inder Singh Institute of Professional Studies

Dehradun, India
SEARCH FILTERS
Time filter
Source Type

Sharma P.,Institute of Management and Technology | Kaushik S.,Gyani Inder Singh Institute of Professional Studies
Journal of Applied Pharmaceutical Science | Year: 2011

Cyamopsis tetragonoloba (L) Taub is a moderate sized annual herb found throughout India as a cultivar for its pods used as vegetable. Plant is popular in indigenous system of medicines like Ayurveda, Siddha and discussed in various traditional literatures. In traditional medicines various parts such as leaves, seeds and pods are used in diabetes, asthma, inflammation, as Laxative, antibilious, appetite depressor (weight loss not observed) and hypolipidemic agent. The present review is therefore, an effort to give a detailed survey of literature on its phytochemistry, traditional and pharmacological uses. © 2010 Medipoeia.


Gangola R.,Gyani Inder Singh Institute of Professional Studies | Kaushik S.,Gyani Inder Singh Institute of Professional Studies | Sharma P.,Nagaji Institute of Pharmaceutical Science
Journal of Applied Pharmaceutical Science | Year: 2011

Simple, sensitive, specific and economic spectrophotometric method was developed and validated for simultaneous quantitation of Hydrochlorothiazide and Telmisartan in tablet dosage form. New method based on the simultaneous estimation of drugs in a binary mixture without previous separation was developed. In simultaneous equation method, Hydrochlorothiazide and Telmisartan were quantified using their absorptivity values of at selected wavelengths, viz., 273 nm and 295 nm respectively. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies. The simultaneous equation method permits simple, rapid and direct determination of Hydrochlorothiazide and Telmisartan in commercially available tablet dosage form without previous separations and can therefore be used for routine analysis of both drugs in quality control laboratories. © 2010 Medipoeia.


Chal J.,Maharishi Markandeshwar University | Kumar V.,Maharishi Markandeshwar University | Kaushik S.,Gyani Inder Singh Institute of Professional Studies
Journal of Applied Pharmaceutical Science | Year: 2011

Tecomella undulata G. Don. is a popular medicinal plant has long been used in ayurvedic system of medicine. The plant has been found to exhibit diverse pharmacological activities. The present paper gives an account of updated information on its photochemical and pharmacological properties. The review of literature reveals that wide range of phytochemical constituents have been isolated from plant and it possesses important pharmacological activities like antibacterial, anticancer and its utility in treatment of certain ailments like syphilis, swelling, leucorrhoea and leucoderma, enlargement of spleen have also been reported. The reports are encouraging hence the herb must be extensively used for its therapeutic benefits. Also the study based on clinical trials should be carried out to support the usage of drug traditionally for treatment of various ailments.


Kathal R.,Amity University | Mishra P.K.,Amity University | Mishra J.,Gyani Inder Singh Institute of Professional Studies
Advanced Science Letters | Year: 2015

This paper describes the preparation and characterization of pure and nanoZnO doped PVDF-PMMA polymer blend-nanocomposites for investigating the charge storage and transfer effects. Fourier transform infrared (FTIR) data is used for characterization and structure elucidation of the blended polymers. Polymer microstructure, chain conformation and polymer morphology were studied to establish the structure activity relations. Cyclic voltammetry (CV) has been chosen to study the electronic properties of the modified polymers as it furnishes information as a function of an energy scan. The effectiveness of CV results from its capability of rapidly observing the redox behavior of the analyte over a wide potential range. Electrode reactions of the intermediates and the products formed during the forward scan have been studied for cardiovascular class of drugs. © 2015 American Scientific Publishers. All rights reserved.


Mishra J.,Gyani Inder Singh Institute of Professional Studies | Mishra P.K.,Amity University
Advanced Science Letters | Year: 2015

Electrical properties of a polymer are partly dependent on their physical as well as chemical structure. PVK is a polar polymer, the probability that charge carrier are present in it, the only charges could come from those injected thorough the electrodes. Electrical conductivity of pure and malachite green doped PVK samples are measured by a two-probe technique. All measurements were performed on solution grown thin films of thickness 50 μm. The injected charges are trapped at different trapping sites leading to a space charge which fundamentally influences all the transport phenomena. The current was found to increase and then decrease with time, and finally attain a steady value. The peak obtained at lower temperature is associated with dipolar relaxation and the other one obtained at high temperature, which appears due to the α-relaxation. © 2015 American Scientific Publishers. All rights reserved.


Garud N.,Gyani Inder Singh Institute of Professional Studies | Garud A.,Gyani Inder Singh Institute of Professional Studies
Tropical Journal of Pharmaceutical Research | Year: 2012

Purpose: To prepare and evaluate metformin microspheres for prolonged release. Methods: Metformin microspheres were prepared by non-aqueous solvent evaporation method using various polymers, including ethylcellulose (EC), hydroxypropyl methylcellulose (HPMC), carbopol 934P (CA) and chitosan (CH). The effect of process variables, viz, drug/polymer ratio, stirring rate and type of polymer on the mean particle size, drug entrapment efficiency, yield, drug content, micromeritic properties and drug release of the microspheres were studied. Results: It was observed that as the stirring speed increased from 600 to 1800 rpm, microsphere size decreased and hence drug release rate increased. Drug release rate at 1:2 drug: polymer for microspheres produced at a stirring rate of 1200 rpm was in the following order: carbopol 934P > HPMC > ethyl cellulose > chitosan. The formulations containing carbopol 934P (CA3) and HPMC (HPMC3) released drug faster than chitosan microspheres (CH3). Conclusion: Amongst the developed microspheres, CH3 formulation (with chitosan as the polymer) exhibited maximum prolonged drug release at gastrointestinal pH or at least 15 h. This oral sustained metformin formulation could potentially improve the bioavailability of the drug as well as patient compliance. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.


Singh A.,Drug Design And Medicinal Chemistry Research Laboratory | Wahi A.K.,Gyani Inder Singh Institute of Professional Studies
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

The increasing clinical importance of drug-resistant fungal and bacterial pathogens has lent additional urgency to microbiological research and new antimicrobial compound development. For this purpose, new a series of Mannich base such as N- [(di substituted-amino) methyl]-N- (4H-1, 2, 4-triazole-4-yl) benzamide 2(a-f) were synthesized by condensation of the 4H-1, 2,4-triazole-4-yl) benzamide with formaldehyde and secondary amine. The chemical structures of these compounds were elucidated by IR, 1H-NMR and elemental analysis. All compounds were screened in vitro for their antibacterial and antifungal activity. The compound 2(c),2(d) was found to have potent antibacterial and anti-fungal activity. © 2010 RJPBCS.


Negi D.,Gyani Inder Singh Institute of Professional Studies | Negi A.,Gb Pant Engineering College | Agarwal S.,Jss Academy Of Technical Education
International Journal of Applied Engineering Research | Year: 2016

Cryptography is an effective way of protecting sensitive information transmitted through network communication paths. It is the science of protecting information by encoding and decoding of input message. In this paper we present an effective two tier complex key encryption/decryption model using dynamical system and fractal sets. © Research India Publications.


Negi D.,Gyani Inder Singh Institute of Professional Studies | Negi A.,Gb Pant Engineering College Pauriuttarakhand
International Journal of Applied Engineering Research | Year: 2016

Iteration is a process that can rapidly produce chaotic behavior in the fields of real and complex numbers. In this paper we have introduced new interesting Julia sets for Tricorn and Multicorns using N-Orbit (Noor orbit). Further, we have also discussed their properties and behavior. © Research India Publications.


Aher V.,NIMS University | Wahi A.,Gyani Inder Singh Institute of Professional Studies
Tropical Journal of Pharmaceutical Research | Year: 2011

Purpose: To investigate the immunomodulatory activity of the alcohol extract of Terminalia chebula Retz (Combretaceae) dried ripe fruits at the cellular level. Methods: For antioxidant study, the liver mitochondria were separated and used for the estimation of enzymes catalase (CAT) and superoxide dismutase (SOD) - as well as lipid peroxidation (LPO) and reduced glutathione (GSH); Melatonin secretion was characterized using sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) while spleen lymphocyte proliferation assay was performed by measuring optical density at 570 nm using ELISA reader. The cytokines, namely, IL-2, IL-10 and TNF-α expression in spleen cells, were determined by real time polymerase chain reaction (RT-PCR) Results: Terminalia chebula extract (100 mg/kg/p.o.) increased the level of liver mitochondrial enzymes CAT and SO) as well as GSH but decreased the level of LPO in the liver when compared to the vehicle, sheep red blood cells (SRBC) and cyclophosphamide-treated groups. Secretion of melatonin by pineal gland was enhanced by T. chebula treatment. The extract also increased spleen lymphocyte proliferation. Based on RT-PCR analysis, the expression of cytokines, viz, IL-2, IL-10 and TNF-α, was more in T. chebula-treated than in vehicle- and cyclophosphamide-treated groups. Conclusion: This study confirms the immunomodulatory activity of ripe T. chebula fruits as evidenced by increase in the concentration of antioxidant enzymes, GSH, T and B cells, the proliferation of which play important roles in immunity. This phenomenon also enhances the concentration of melatonin in pineal gland as well as the levels of cytokines, such as IL-2,IL-10 and TNF-α, which play important roles in immunity. © Pharmacotherapy Group.

Loading Gyani Inder Singh Institute of Professional Studies collaborators
Loading Gyani Inder Singh Institute of Professional Studies collaborators