Gwangyang Health College

Gwangyang, South Korea

Gwangyang Health College

Gwangyang, South Korea

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Kim J.,Chonnam National University | Lee C.M.,Chonnam National University | Kim D.-W.,Gwangyang Health College | Lee K.-Y.,Chonnam National University
Polymer (Korea) | Year: 2013

The purpose of this study was to develop an aloin-loaded wound dressing with an enhanced healing effect. The cross-linked hydrogel films were prepared with polyvinyl alcohol) (PVA) and carboxyl methyl cellulose (CMC) using a freeze-thawing (F-T) method. Their gel properties, release of drug, in vivo wound healing effect and histopathology were then evaluated. In the wound healing test, this aloin loaded PVA/CMC hydrogel showed faster healing of the wound made in rat dorsum than the aloin carbomer 934 gel or the control (carbomer 934 gel) due to phytochemical activity of aloin and moisture of CMC. In conclusion, the aloin-loaded wound dressing composed of 5% PVA, 5% CMC and 0.125% aloin is a potential wound dressing with enhanced wound healing effect.


Kim J.,Chonnam National University | Bea S.K.,Chonnam National University | Bea S.K.,SION BSK Co. | Kim Y.H.,Chonnam National University | And 4 more authors.
Biotechnology and Bioprocess Engineering | Year: 2015

We prepared and characterized calcium carbonate nanoparticles (CC NPs) that were surface-modified with oleic acid (OA) and phosphatidylcholine (PC) in order to improve their suspension stability in an aqueous solution. The improvement in the suspension stability of CC NPs in an aqueous solution may be helpful to extend their applicability to a wider range of biological applications. The CC NPs were coated with OA by making use of their electrostatic potential and were then decorated with PC. The CC NPs surface-modified with OA and PC were successfully constructed, and the existence of the decorated OA and PC in the surface of the PC-OA-CC NPs was observed via transmission electron microscopy (TEM) and was confirmed by thermo gravimetric analysis (TGA), Xray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR) analyses. The PC-OA-CC NPs floating in an aqueous solution exhibited better stability when compared to non-surface-modified CC NPs. The DLS and TEM results revealed that the degree of size agglomeration for the CC NPs was significantly reduced by the surface modification with OA and PC. The PC-OA-CC NPs showed a very low cytotoxicity at a high concentration in terms of the cell viability of the RAW264.7 cells. Consequentially, the stability in suspension of the CC NPs in an aqueous solution could be effectively improved through surface-modification with OA and PC. PC-OACC NPs could be useful in increasing the range biological applications for CC NPs. © 2015, The Korean Society for Biotechnology and Bioengineering and Springer-Verlag Berlin Heidelberg.


Kim J.,Chonnam National University | Lee C.-M.,Chonbuk National University | Jeong H.-J.,Chonbuk National University | Kim D.-W.,Gwangyang Health College | Lee K.-Y.,Chonnam National University
Journal of Nanoscience and Nanotechnology | Year: 2012

The formation of nanoparticles from eicosapentaenoic acid (EPA) is crucial to improving EPA's bioavailability and pharmacological properties, and widening its use in biomedical fields. In this study, we report EPA-conjugated glycol chitosan (GC) that can self-aggregate into core-shell nanoparticles. The EPA-GC nanoparticles were internalized into the cytosol of RAW 264.7 cells by endocytosis, which results in effective delivery of EPA to the cells. There were no differences in the cell viability after the treatment with EPA-GC nanoparticles. In the anti-inflammatory studies, the EPA-GC nanoparticles significantly inhibited lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production and interleukin-1 beta (IL-1 beta) secretion in RAW 264.7 cells. The anti-inflammatory effects of the EPA-GC nanoparticles were far better than those seen for EPA only. Given their excellent bio-physicochemical properties, it is expected that EPA-GC nanoparticles may have a potential for widening the use of EPA in biomedical fields and, in particular, the treatment of inflammatory diseases. Copyright © 2012 American Scientific Publishers.


Han J.-S.,Severance Hospital | Dong K.-R.,Gwangju University | Dong K.-R.,Chosun University | Chung W.-K.,Chosun University | And 6 more authors.
Journal of Magnetics | Year: 2012

Although 3.0T magnetic resonance imaging (MRI) has the advantages of a higher signal to noise ratio (SNR) and contrast than 1.5T MRI, there are limitations on the contrast between white and grey matter because of the long T1 recovery time when T1 images are obtained using the Spin Echo Technique. To overcome this, T1 weighted images are obtained occasionally using the inversion recovery (IR) technique, which employs a relatively long TR. The aim of this study was to determine the optimal TI in a brain examination when a T1 weighted image is obtained using the IR technique. Eight participants (male: 7, female: 1, average age: 34 ± 14.11) with a normal diagnosis were targeted from February 18, 2012 to February 27, 2012, and the contrast between white and grey matter as well as the contrast to noise ratio (CNRs) in each participant were measured. The CNRs of white matter and grey matter were highest at TI = 600, 650, 750, 900, 1050 and 1100 ms when the TR was 1100, 1400, 1700, 2000, 2300 and 2600 ms, respectively. Therefore, as the TIs were 44.425 ± 0.877% of the TRs in the TR range of 1400-2300 ms, the optimal T1 weighted images that describe the contrast between white and grey matter can be obtained if the TIs are compensated for with 44.425 ± 0.877% of the TRs in the time of setting TIs. © 2012 Journal of Magnetics.


Lee C.-M.,Chonbuk National University | Park J.-W.,Chonnam National University | Kim J.,Chonnam National University | Kim D.-W.,Gwangyang Health College | And 2 more authors.
Drug Development and Industrial Pharmacy | Year: 2010

Objective: In this study, the influence of N-acetyl histidine (NAHis) on the all-trans retinoic acid (ATRA) release from the NAHis-conjugated self-assembled glycol chitosan (GC) nanoparticles was investigated. Methods: NAHis was conjugated to GC as a hydrophobic moiety to prepare the self-assembled nanoparticles, and ATRA was incorporated into the inner core of the NAHisGC nanoparticles. The ATRA release from NAHisGC nanoparticles was performed at 37°C in a phosphate-buffered saline buffer (pH 5.5 or 7.4) for 48 hours. Results: At a pH of 5.5, less than 20 (ww) of total loading amount of ATRA was released from the nanoparticles after 48 hours. In contrast, two times greater amount of ATRA was released at a pH of 7.4. The ATRA release rate from the NAHisGC nanoparticles was significantly slower at a pH of 5.5 than at a pH of 7.4. Conclusion: The release profiles of ATRA that was incorporated into the NAHisGC nanoparticles were controlled by the NAHis content in the GC nanoparticles. © 2010 Informa UK, Ltd.


Joo K.-J.,Gwangju University | Shin J.-W.,Gwangju University | Shin J.-W.,Chonbuk National University | Dong K.-R.,Gwangju University | And 5 more authors.
Journal of the Korean Physical Society | Year: 2013

Reducing the exposure dose from a periapical X-ray machine is an important aim in dental radiography. Although the radiation exposure dose is generally low, any radiation exposure is harmful to the human body. Therefore, this study developed a method that reduces the exposure dose significantly compared to that encountered in a normal procedure, but still produces an image with a similar resolution. The correlation between the image resolution and the exposure dose of the proposed method was examined with increasing distance between the dosimeter and the X-ray tube. The results were compared with those obtained from the existing radiography method. When periapical radiography was performed once according to the recommendations of the International Commission on Radiological Protection (ICRP), the measured skin surface dose was low at 7 mGy or below. In contrast, the skin surface dose measured using the proposed method was only 1.57 mGy, showing a five-fold reduction. These results suggest that further decreases in dose might be achieved using the proposed method. © 2013 The Korean Physical Society.


Park J.S.,Hanbat National University | Kim J.M.,Hanbat National University | Song Y.H.,Hanbat National University | Lim D.W.,Hanbat National University | And 3 more authors.
Materials Science Forum | Year: 2011

Mg alloys are one attractive material in applications of transportations and mobile electronics due to their high specific strength compared with other structural materials. However, Mg alloys often exhibit relatively low strength and/or low surface stability, which can limit the practical application of the alloy system. In this perspective, thermo-mechanical treatments of the alloy can give enhanced materials strength, so that the application of the alloy system can be extended towards new structural parts for requiring the light nature of the alloy system. In this study, a high temperature extrusion has been carried out for the commercial Mg alloys (AZ31). The extrusion temperature and extrusion ratio critically affected the alloy strength and ductility. The texture development and alloy strengths with respect to the extrusion conditions have been discussed in terms of microstructural observations and phase analyses. © (2011) Trans Tech Publications.


Baik K.S.,Sunchon National University | Choe H.N.,Sunchon National University | Park S.C.,Sunchon National University | Hwang Y.M.,Sunchon National University | And 3 more authors.
International Journal of Systematic and Evolutionary Microbiology | Year: 2013

Two yellow-pigmented, Gram-reaction-negative strains, designated 01SU5-PT and 03SU3-PT, were isolated from the freshwater of Woopo wetland, Republic of Korea. Both strains were aerobic, non-motile and catalase-negative. Phylogenetic analysis based on 16S rRNA gene sequences indicated that the two isolates belong to the genus Sphingopyxis, showing the highest level of sequence similarity with respect to Sphingopyxis witflariensis W-50T (95.4-95.7%). The two novel isolates shared 99.4% sequence similarity. DNA-DNA hybridization between the isolates and the type strain of S. witflariensis clearly suggested that strains 01SU5-PT and 03SU3-PT represent two separate novel species in the genus Sphingopyxis. The two strains displayed different fingerprints after PCR analysis using the repetitive primers BOX, ERIC and REP. Several phenotypic characteristics served to differentiate these two isolates from recognized members of the genus Sphingopyxis. The data from the polyphasic study presented here indicated that strains 01SU5-PT and 03SU3-PT should be classified as representing novel species in the genus Sphingopyxis, for which the names Sphingopyxis rigui sp. nov. and Sphingopyxis wooponensis sp. nov., respectively, are proposed. The type strain of Sphingopyxis rigui sp. nov. is 01SU5-PT (=KCTC 23326T=JCM 17509T) Printed in Great Britain.


Kim Y.-J.,Gwangyang Health College | Kim Y.-J.,Dongshin University | Jang S.-J.,Dongshin University | Han J.-B.,Dongshin University | And 4 more authors.
Annals of Nuclear Energy | Year: 2014

The aim of this study was to determine the proper position for the radiation treatment of liver cancer by tomotherapy by comparing the changes in the target location and volume depending on the position (prone position and supine position). Among the patients diagnosed with hepatocellular carcinoma from January to December 2012, five patients who had a similar tumor size and location were selected as study subjects. An abdominal and chest motion control device (radiation therapy device) was used to guide free respiration while Body Fix was used to minimize the motion of the abdomen. 4DCT was conducted in both the supine and prone positions. After the CT image was obtained, the contour of the target was determined before Tomotherapy Planning System Ver. 4.2 (Tomotherapy, Inc. Madison, WI, USA) was used to complete a plan and analyze the motion of the target. A dose volume histogram was used to analyze the integral dose. When the radiation treatment was conducted in the prone position, the motion due to respiration was reduced more than in the supine position (SI direction: 1.7 mm, AP direction: 0.7 mm, and LR direction: 0.2 mm) and the target volume was also reduced (GTV: 11.7 cm3, CTV: 19.4 cm 3, and PTV: 14.1 cm3). As a result, the dose in the PTV increased by 3.4% at the maximum, whereas the dose reduction was 27.8% (V 50) for the normal tissue of a normal liver: 53% (V30) for the stomach, 75% (V25) for the right kidney, and 50% (V 45) for the spinal cord. Therefore, the maximum dose was assigned to the tumor tissue and at the same time, the minimum dose was observed in the normal tissue, showing a high therapeutic ratio (TR). In liver cancer treatment using tomotherapy, motion of the target volume can be minimized when the patient is placed in the prone position, rather than in the supine position. In addition, the proper dose of radiation was assigned to the tumor tissue and the absorbed dose was lower in the normal tissue. © 2013 Elsevier Ltd. All rights reserved.


Kim C.-B.,Gwangju University | Dong K.-R.,Gwangju University | Dong K.-R.,Dongshin University | Gho H.-J.,Chosun University | And 3 more authors.
Journal of the Korean Physical Society | Year: 2013

This study examined the changes in the center frequency according to the fat content the using a self-manufactured phantom. In addition, the change in the fat saturation image according to when the center frequency was applied automatically or adjusted manually was analyzed to determine the importance of a manual adjustment of the center frequency. Distilled water and animal fat were solidified in a 10-ml syringe to manufacture nine phantoms for each condition (18 in total). A MR scanner at 1.5 Tesla was used to obtain a T1-weighted three dimensional fast low-angle shot (T1 3D FLASH) dynamic fat saturation image according to the spectral attenuated inversion recovery(SPAIR) method. The images obtained were classified into the following before analyzing the center frequencies for each image: Test A (image where fat was not saturated), Test B (image where fat was saturated in an automatic adjustment of the center frequency), and Test C (image where fat was saturated in a manual adjustment of the center frequency). The signal intensity (SI) values of water, fat and background were measured to calculate the signal to noise ratio (SNR) before examining the difference in the SNRs of water and fat (SNR difference = water SNR - fat SNR). The mean center frequency in Tests A, B and C was 63.631179 MHz when the fat content was 70% or lower. The mean center frequency for Tests A and B was 63.631002 MHz when the fat content was 80% or higher, which was 226 Hz lower than that for Test C (63.631228 MHz). The water SIs of Tests A, B and C with increasing fat content showed a pattern of change similar to that of the fat SIs of Tests A and C. On the other hand, the fat SI of Test B was similar to that of Test A when the fat content was 80%, which showed a large difference in change. The water SNRs of Tests A, B and C, and the fat SNR and SNR differences of Tests A and C showed similar changes according to the fat content. The difference between the fat SNR and the SNR of Test B was similar to that of Test A when the fat content was 80%. © 2013 The Korean Physical Society.

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