Gwangju, South Korea
Gwangju, South Korea

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Yang T.Y.,Haenam General Hospital | Lee J.H.,Jangheung General Hospital | Song H.-J.,Gwangju Health College | Shim S.-K.,National Institute of Health | And 2 more authors.
Clinical Microbiology and Infection | Year: 2010

Many countries where scrub typhus is endemic use their own cutoff values for antibody titres to differentiate between cured cases and current infections. To establish an antibody titre cutoff value, one needs to investigate the seroprevalence in endemic areas, and the duration of the increase in titre after complete cure. We conducted a follow-up study of anti- Orientia tsutsugamushi antibody titres using indirect immunofluorescence assays (IFA) and passive haemagglutination assays (PHA) in patients with scrub typhus. After the onset of symptoms, IgM antibody titres increased gradually over 2-3 weeks, peaked at about 4 weeks, and started to decrease rapidly between 4 and 5 weeks. At 1-year follow-up, the median IgM value was 1:10. Out of 77 patients who were tested at that time, 36 (47%) had IgM titres ≥1:20, and none had titres exceeding 1:80. Over the first 2 weeks, IgG antibody titres increased sharply, peaked at about 4 weeks and decreased rather gradually thereafter, with a median titre of 1:128 maintained up to the 18th month. At 1-year follow-up, five out of 77 patients (6.5%) had titres ≥1:1,024 and 57% had titres ≥1:128. Based on these results, a cutoff value of ≥1:160 for IgM antibody should differentiate between previous and current infections in endemic areas such as Korea and Japan, where scrub typhus occurs mainly in the autumn. © 2009 The Authors. Journal Compilation © 2009 European Society of Clinical Microbiology and Infectious Diseases.

Song H.-R.,Chonnam National University | Kim H.N.,Chonnam National University | Kweon S.-S.,Chonnam National University | Choi J.-S.,Chonnam National University | And 8 more authors.
Molecular Carcinogenesis | Year: 2013

A recent genome-wide association study (GWAS) identified new susceptibility single-nucleotide polymorphisms (SNPs) rs13361707 (PRKAA1 and PTGER4 gene on 5p13.1) and rs9841504 (ZBTB20 gene on 3q13.31) that were significantly associated with non-cardia gastric cancer. The aim of this study was to determine whether rs13361707 and rs9841504 polymorphisms are associated with the risk of gastric cancer in a Korean population. We conducted a large-scale case-control study of 3245 gastric cancer patients and 1700 controls. The allele frequencies for rs13361707 C and rs9841504 G were 53.5% and 18.3% among gastric cancer cases, compared with 47.1% and 17.2% among controls, respectively. We found that rs13361707 TC and CC genotypes were associated with increased risk for gastric cancer (odds ratios [OR]=1.29; 95% confidence interval [CI]=1.11-1.51 for TC vs. TT and 1.68; 1.41-2.01 for CC vs. TT). However, we found no significant association between rs9841504 and gastric cancer risk (OR=1.11; 0.97-1.28 for CG vs. CC; OR=1.09; 0.77-1.53 for GG vs. CC). We observed no significant interactions between rs13361707 and rs9841504 polymorphisms and age, gender, smoking habit, alcohol consumption, and clinicopathologic characteristics such as anatomical tumor location and histological type. Our study showed that the rs13361707 polymorphism was associated with increased risk of gastric cancer in a Korean population. This finding provides further evidence that genetic variant of PRKAA1 and PTGER4 genes may contribute to the gastric carcinogenesis. However, we found no association between rs9841504 and gastric cancer risk. © 2013 Wiley Periodicals, Inc.

Song H.-R.,Chonnam National University | Kim H.N.,Chonnam National University | Kweon S.-S.,Chonnam National University | Choi J.-S.,Chonnam National University | And 8 more authors.
Tumor Biology | Year: 2014

Genetic variants at 1q22 and 10q23 were identified as genetic markers of both gastric cancer and esophageal squamous cell carcinoma susceptibility by two genome-wide association studies. The aim of this study was to determine whether rs4072037A > G in MUC1 at 1q22 and rs2274223A > G in PLCE1 at 10q23 are associated with a risk of gastric cancer in a Korean population. We conducted a large-scale case-control study of 3,245 patients with gastric cancer and 1,700 controls. The allele frequencies of rs4072037G and rs2274223G were 11.2 and 25.5 % among patients with gastric cancer, compared with 12.8 and 26.4 %, respectively, among controls. We found that the rs4072037 AG genotype was significantly associated with a reduced risk of gastric cancer [odds ratios (OR) = 0.78; 95 % confidence interval (CI) = 0.67-0.91 for AG vs AA]. Compared with the rs2274223 AA genotype, we found a significant association between the rs2274223 AG genotype and a weakly reduced risk of gastric cancer (OR = 0.87; 95 % CI = 0.76-0.99 for AG vs AA). Our data suggest that genetic variants at 1q22 and 10q23 play a role in gastric carcinogenesis. © 2013 International Society of Oncology and BioMarkers (ISOBM).

Lee I.-Y.,Yonsei University | Song H.-J.,Gwangju Health College | Choi Y.-J.,Konkuk University | Shin S.-H.,Konkuk University | And 8 more authors.
Korean Journal of Parasitology | Year: 2014

A total of 9,281 larval chigger mites were collected from small mammals captured at Hwaseong-gun, Gyeonggi-do (Province) (2,754 mites from 30 small mammals), Asan city, Chungcheongnam-do (3,358 mites from 48 mammals), and Jangseong-gun, Jeollanam-do (3,169 for 62 mammals) from April-November 2009 in the Republic of Korea (= Korea) and were identified to species. Leptotrombidium pallidum was the predominant species in Hwaseong (95.8%) and Asan (61.2%), while Leptotrombidium scutellare was the predominant species collected from Jangseong (80.1%). Overall, larval chigger mite indices decreased from April (27.3) to June (4.9), then increased in September (95.2) and to a high level in November (169.3). These data suggest that L. pallidum and L. scutellare are the primary vectors of scrub typhus throughout their range in Korea. While other species of larval chigger mites were also collected with some implications in the transmission of Orientia tsutsugamushi, they only accounted for 11.2% of all larval chigger mites collected from small mammals. © 2014, Korean Society for Parasitology and Tropical Medicine.

Baik K.S.,Korea Basic Science Institute | Choi J.-S.,Korea Basic Science Institute | Kwon J.,Korea Basic Science Institute | Park S.C.,Sunchon National University | And 7 more authors.
International Journal of Systematic and Evolutionary Microbiology | Year: 2013

A pink-pigmented, chemo-organotrophic bacterium, designated strain 03SUJ4T, was isolated from the freshwater of Juam reservoir, Republic of Korea (35° 03′ 43″ N 127° 14′ 15″ E). Cells were aerobic, Gram-reaction-negative and non-motile rods. Strain 03SUJ4T grew at pH 6-7 (optimum, pH 6) and at 15-30 °C (optimum, 25 °C). Phylogenetic analysis based on 16S rRNA gene sequences indicated that the isolate belonged to the genus Terriglobus, showing sequence similarities of 97.09 % and 96.82 % to Terriglobus roseus DSM 18391T and Terriglobus saanensis SP1PR4T, respectively. Low rpoB gene sequence similarity with members of the genus Terriglobus and different fingerprints with the repetitive primers BOX, ERIC and REP indicated that the isolate represented a novel species of the genus Terriglobus. The major cellular fatty acids were iso-C15: 0, C16: 0, C20: 1ω9c, C14: 0 and summed feature 3 (C16: 1ω7c/C16: 1ω6c). The DNA G+C content of strain 03SUJ4T was 63.2±0.1 mol% (mean±SD of three determinations). The predominant menaquinone was MK-8. The major polar lipids were phosphatidylethanolamine, diphosphatidylglycerol, phosphatidylglycerol and two unidentified phospholipids. Several phenotypic characteristics served to differentiate the novel isolate from recognized members of the genus Terriglobus. On the basis of the evidence presented in this study, a novel species, Terriglobus aquaticus sp. nov. is proposed for strain 03SUJ4T (= KCTC 23332T = JCM 17517T). © 2013 IUMS.

Baik K.S.,Sunchon National University | Choe H.N.,Sunchon National University | Park S.C.,Sunchon National University | Hwang Y.M.,Sunchon National University | And 3 more authors.
International Journal of Systematic and Evolutionary Microbiology | Year: 2013

Two yellow-pigmented, Gram-reaction-negative strains, designated 01SU5-PT and 03SU3-PT, were isolated from the freshwater of Woopo wetland, Republic of Korea. Both strains were aerobic, non-motile and catalase-negative. Phylogenetic analysis based on 16S rRNA gene sequences indicated that the two isolates belong to the genus Sphingopyxis, showing the highest level of sequence similarity with respect to Sphingopyxis witflariensis W-50T (95.4-95.7%). The two novel isolates shared 99.4% sequence similarity. DNA-DNA hybridization between the isolates and the type strain of S. witflariensis clearly suggested that strains 01SU5-PT and 03SU3-PT represent two separate novel species in the genus Sphingopyxis. The two strains displayed different fingerprints after PCR analysis using the repetitive primers BOX, ERIC and REP. Several phenotypic characteristics served to differentiate these two isolates from recognized members of the genus Sphingopyxis. The data from the polyphasic study presented here indicated that strains 01SU5-PT and 03SU3-PT should be classified as representing novel species in the genus Sphingopyxis, for which the names Sphingopyxis rigui sp. nov. and Sphingopyxis wooponensis sp. nov., respectively, are proposed. The type strain of Sphingopyxis rigui sp. nov. is 01SU5-PT (=KCTC 23326T=JCM 17509T) Printed in Great Britain.

Lee Y.S.,Sunchon National University | Lee D.-H.,Sunchon National University | Kahng H.-Y.,Sunchon National University | Kim E.M.,Gwangju Health College | Jung J.S.,Sunchon National University
International Journal of Systematic and Evolutionary Microbiology | Year: 2010

A novel Gram-negative, aerobic, orange-pigmented bacterial strain, designated K7-2T, was isolated from seawater of Gangjin Bay, Korea, and subjected to a polyphasic taxonomic study. Strain K7-2T contained ubiquinone-10 (Q-10) as the predominant respiratory lipoquinone and did not produce bacteriochlorophyll a. Major fatty acids were C 18 : 1ω7c (51.4 %), iso-C15 : 0 2-OH and/or C 16 : 1ω7c (15.0 %) and C17 : 1ω6c (8.8 %). Major polar lipids were phosphatidylethanolamine and phosphatidylcholine. The DNA G+C content was 61.6 mol%. Phylogenetic analyses based on 16S rRNA gene sequences revealed that strain K7-2T formed a distinct phylogenetic lineage within the cluster comprising Erythrobacter strains. Similarities between the 16S rRNA gene sequences of strain K7-2T and the type strains of Erythrobacter species ranged from 95.0% (Erythrobacter litoralis DSM 8509T) to 96.8% (Erythrobacter citreus RE35F/1T). On the basis of polyphasic taxonomic data, strain K7-2T (=KCTC 22330 T=JCM 15420T) is classified in a novel species within the genus Erythrobacter, for which the name Erythrobacter gangjinensis sp. nov. is proposed. © 2010 IUMS.

Lee C.-Y.,Gwangju Health College | Kim J.-T.,Chosun University
Applied Chemistry for Engineering | Year: 2010

Cryptand resins have been synthesized from 1-aza-18-crown-6 macrocyclic ligand attached to styrene (2th petroleum in 4th class hazardous materials) divinylbenzene copolymer with crosslinkage of 1%, 2%, 10%, and 18% by substitution reaction. The synthesis of these resins was confirmed by the content of chlorine, element analysis, surface area (BET), and IR-spectroscopy. The effects of pH, time and crosslinkage on adsorption of metal ion from water fire extinguishing agent by synthetic resin adsorbent were investigated. Metal ions showed a great adsorption over pH 3 and adsorption equilibrium of metal ions was about two hours. The adsorption selectivity determined in water was in the increasing order of sodium (Na 1+) > zinc (Zn 2+)> chromium (Cr 3+) ion. The adsorption was in the order of 1%, 2%, 10%, and 18% crosslinkage resin.

Joo K.J.,Gwangju Health College | Song K.W.,Dental Design Co. | Jung J.H.,Gwangju Health College | Ahn H.J.,Chonbuk National University | And 3 more authors.
Metals and Materials International | Year: 2011

To evaluate the effect of melt infiltration on the biaxial flexural strength of porcelain-bonded zirconia, borosilicate glasses were used in this study. Presintered yttria-stabilized tetragonal zirconia polycrystals (Y-TZP) blocks were milled and used for disc specimens. Prior to veneering of porcelain, the infiltration of borosilicate glass on zirconia was performed at 1,100 °C for 1 h. After a biaxial flexural test with the crosshead speed of 0.1 mm/min, fractured surfaces and interfaces between zirconia and veneer porcelain were observed with a Scanning Electron Microscope (SEM). The fracture strength of sintered zirconia and veneer porcelain was significantly increased by the melt infiltration of borosilicate glass (P < 0.05). The melt infiltration process of borosilicate glass greatly improved the Weibull modulus of sintered zirconia. However, the Weibull modulus of porcelain increased slightly. The sintered zirconia group showed a smooth fracture surface containing many pores, but the glass-infiltrated zirconia group showed a rough fracture surface. © 2011 The Korean Institute of Metals and Materials and Springer Netherlands.

Song H.S.,Gwangju Health College | Sawamura M.,Kochi University
Journal of Essential Oil Research | Year: 2010

The volatile profile of 'Setoka,' a cold-pressed peel oil of a citrus hybrid was investigated by GC and GC/MS. Among the 74 components quantified in Setoka oil, 24 terpene hydrocarbons and 50 oxygenated compounds were identified, with peak weight percentages of 82.6 % and 16.8%, respectively. The major components of Setoka oil were limonene (77.3%), (Z)-nerolidol (4.2%), myrcene (1.9%), (E)-2-dodecenal (1.8%) and cw-carveol (1.0%). Although limonene was the most prominent component in Setoka oil, its content was relatively low compared to the commonly encountered citrus peel oils. A peculiarity of the volatile profile of Setoka oil was the ratio of alcohols (8.8%) to aldehydes (4.9%), which resulted from the relative abundance of (Z)-nerolidol andcis-carveol. The level of esters (1.7%) was another characteristic of Setoka oil. A significant feature of Setoka oil was suggested to the relative affluence in (Z)-nerolidol, (E)-2-dodecenal, carvone and α-terpinyl acetate. © 2010 Allured Business Media.

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