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Cambridge, MA, United States

Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 149.58K | Year: 2014

DESCRIPTION (provided by applicant): Prefilled syringes are used with increasing frequency in parenteral drug administration. Their advantages include reducing medical errors, ease of use, accurate dosage, elimination of preservatives, and enabling of patient-controlled self-therapy. However, most commercial protein-based drugs are not compatible with prefilled syringes. This is because of complications that arise from the almost ubiquitous presence of silicone oil that is used as lubricant to aid in syringe plunger depression and to ensure reliable and safe operation. Silicone microdroplets that shed from the lubricated surfaces of the syringe react with the drug medium and cause aggregation of protein therapeutics compromising their safety and efficacy. Attempts to replace standard silicone oil lubricant in prefilled syringes have thus far fallen short in achieving sufficiently high lubricity and chemical inertness. To address this problem GVD Corporation proposes to develop a highly inert, low- parti

GVD Corporation | Date: 2013-04-03

Methods for improving the adhesion of vacuum deposited coatings to a wide variety of substrates are described herein. The methods include utilizing a thermal source to generate free radical species which are then contacted to the substrate to be coated. Chemical vapor deposition, particularly initiated chemical vapor deposition (iCVD) can be used to form polymer thin films in situ without the need to remove the substrate from the chamber or even return to atmospheric pressure. Significant improvements in substrate adhesion of the subsequently deposited films have been observed over a range of substrate and coating materials.

GVD Corporation | Date: 2014-01-17

Medical articles with coatings are disclosed herein, as well as methods and systems for depositing these coatings onto medical articles. Surfaces of such articles may be coated. The coating(s) may serve as lubricants for reducing suction between such surfaces or between a coated surface and another surface.

GVD Corporation | Date: 2014-04-29

Liquid-impregnated textured coatings containing one or more materials on a variety of surfaces are described herein. The coatings can be prepared by chemical vapor deposition techniques or other techniques known in the art. The texture can be random, fractal, or patterned. The texture can be pores, cavities, and/or micro- and/or nanoscale features/structures. The capillary forces arising from the nano- or microscopic texture of the coating stabilizes the liquid within the textured features and at the surface of the coating resulting in non-wetting properties for a variety of surfaces. They coatings may be formed in a single layer or as multiple layers. In order to maximize ease of deposition and processing, the coating may be formed of graded composition to optimize both bulk and surface properties without the need for multiple coatings.

GVD Corporation | Date: 2014-07-25

Molds that have coated mold surfaces, as well as methods and components associated with such molds, are provided. The mold surface coatings may be formed of a polymeric material, such as polytetrafluoroethylene (PTFE), and may be very thin (e.g., 50 microns or less). The coatings may facilitate the release of articles formed in the mold and may also reduce, or eliminate, the build up of contaminants on mold surfaces during processing which, thus, increases mold lifetime. The coatings may be formed in a chemical vapor deposition process with process conditions selected to enable formation of uniform, conformal coatings, even on mold features having small dimensions and/or high aspect ratios. The coatings are particularly well suited to be used in connection with rubber tires molds, though also can be used in other types of molds and articles.

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