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Ibrahimpatnam, India

Sravan Prasad M.,GBN Institute of Pharmacy | Venkateshwarlu G.,Venkateshwara Institute of Pharmaceutical science | Alekhya K.,GBN Institute of Pharmacy | Pawan kumar B.,Guru nanak Institute of Pharmacy | Venkat Rajkumar J.,GBN Institute of Pharmacy
Research Journal of Pharmaceutical, Biological and Chemical Sciences

The entire wound healing process is a complex series of events that begins at the moment of injury and can continue for months to years. The objective of our study is to investigate wound healing activity of the methanolic leaf extract of Pongamia pinnata in albino rats using excision and incision wound models. 200 mg/kg/day of leaf extract of pongamia pinnata was evaluated for its wound healing activity and compared with povidone iodine (Standard). The present investigation may be concluded that the plant Pongamia pinnata is endowed with significant wound healing activity due to the presence active constituents, there by justifying its use in the indigenous system of medicine. Source

Verma S.,Rayat Bahra Institute of Pharmacy | Jain A.K.,Guru nanak Institute of Pharmacy
Artificial Cells, Nanomedicine and Biotechnology

Human immunodeciency virus (HIV) infection has become devastating in last a few years. Nearly 7400 new infection cases are coming every day. Highly active antiretroviral therapy (HAART), which involves combination of at least three antiretroviral (ARV) drugs, has been used to extend the life span of the HIV-infected patients. HAART has played an important role to reduce mortality rate in the developed countries but in the developing countries condition is still worst with millions of people being infected by this disease. For the improvement of the situation, nanotechnology-based drug system has been explored for the HIV therapeutics. Nanosystems used for HIV therapeutics offer some unique advantage like enhancement of bioavailability, water solubility, stability, and targeting ability of ARV drugs. Main nanotechnology-based systems explored for HIV therapeutics are liposomes, nanoparticles, niosomes, polymeric micelles, and dendrimers. Present manuscript reviews conventional method of HIV therapeutics and recent advances in the eld of nanotechnology-based systems for treatment of HIV-AIDS. © 2014 Informa Healthcare USA, Inc. Source

Gadapuram T.K.,Guru nanak Institute of Pharmacy | Murthy J.S.N.,Vignana Bharathi Institute of Technology | Rajannagari R.R.,Malla Reddy Pharmacy College | Kandati V.,Malla Reddy Pharmacy College | Shukla R.,Amity University
Journal of Basic and Clinical Physiology and Pharmacology

Background: Cocculus hirsutus, commonly known as broom creeper, belongs to the family Menispermaceae. It is widely used in folk medicine to treat leprosy, skin diseases, dyspepsia, etc. Hence, an effort has been made to investigate the nephroprotective potential of C. hirsutus. Methods: The nephroprotective activity of ethanolic C. hirsutus leaf extract (ECHE) in the 5/6 nephrectomized rat model was investigated. Different parameters like postoperative survival rate, change in body weight and levels of red blood corpuscles (RBCs), hemoglobin (Hb), triglyceride, cholesterol, creatinine, urea and uric acid were estimated in experimental rats. Results: The findings revealed the postoperative survival rate of rats in the investigated novel method to be 100%. Change in the body weight of ECHE-treated groups I and II was found to be 32 and 30 g, respectively. These values suggested that ECHE treatment normalized the elevated body weight levels in experimental rats. Furthermore, ECHE treatment normalized the decreased RBC levels and the elevated Hb, triglyceride, cholesterol, creatinine, urea and uric acid levels in experimental rats. Conclusions: The results indicate that C. hirsutus has strong nephroprotective activity. However, further scrutiny is essential for isolation and characterization of the active components that can be employed to allay various human maladies. Source

Mandade R.J.,Maharashtra Institute of Pharmacy | Choudhury A.,Guru nanak Institute of Pharmacy | Harsulkar A.,Maharashtra Institute of Pharmacy | Wakade R.,Maharashtra Institute of Pharmacy
Indian Journal of Pharmacology

Objectives: The objective of the study was to investigate the effect of the leaf extract of Rosa canina L. against experimental diarrhea induced by castor oil in rodents. Materials and Methods: The methanol extract of Rosa canina L. (30 and 60 mg/kg body weight) was administered orally to two groups of mice (five animals per group) in order to evaluate the activity of the extract against the castor oil-induced diarrhea model in mice. Two other groups received normal saline and diphenoxylate (5 mg/kg) as positive control. The effect of the extract on intestinal transit and castor oil-induced intestinal fluid accumulation (enteropooling) was assessed. The effects of the extract on the isolated rabbit jejunum and on the isolated rat ileum were studied. Results: The preliminary phytochemical screening of the leaf extract of Rosa Canina L. revealed the presence of alkaloids, flavonoids, glycosides, saponins, and volatile oil. Intraperitoneal LD50 of the extract was found to be 455.19 ± 23 mg/kg in mice. The antidiarrheal effect of the methanolic extract exhibited a concentration-dependent inhibition of the spontaneous pendular movement of the isolated rabbit jejunum and inhibited acetylcholine-induced contraction of the rat ileum. A dose-dependent decrease in gastrointestinal transit was observed with extracts (30 and 60 mg/kg), which also protected mice against castor oil-induced diarrhea and castor oil-induced fluid accumulation, respectively. Conclusions: The presence of some of the phytochemicals in the leaf extract may be responsible for the observed effects, and also the basis for its use in traditional medicine as an antidiarrheal drug. Source

Mandade R.J.,S N Institute Of Pharmacy | Sreenivas S.A.,Guru nanak Institute of Pharmacy | Sakarkar D.M.,S N Institute Of Pharmacy | Choudhury A.,Shree Dhanvantary college pharmacy
Asian Pacific Journal of Tropical Medicine

Objective: To explore the effects of extract of Hibiscus rosasinensis (H. rosasinensis) on the volume, free and total acidity of gastric secretion induced by carbachol. Methods: Animals were kept on fasting for 48 h, then the pylorus of each animal was ligated. They were randomly divided into 5 groups and treated by carbachol at 600 μg/kg. Then animals in group II - V were treated by H. rosasinensis extract at 250 and 500 mg/kg body weight, cimetidine at 2.5 mg/kg and verapamil at 10 mg/kg body weight intraperitoneally, respectively. The volume, free and total acidity of gastric secretion were observed and compared. Results: It was found that the extract significantly reduced the volume, free and total acidity of gastric secretion (P<0.01). These reductions were comparable to cimetidine and verapamil. And the reduction in the volume and free acidity were more significant in cimetidine and verapamil treated group indicating that cimetidine and verapamil were more effective. Conclusions: The extract of H. rosasinensis can reduced the volume, free and total acidity of gastric secretion, and can be used effectively in the treatment of peptic ulcer. © 2011 Hainan Medical College. Source

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