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Saha P.,Jadavpur University | Saha P.,Guru Nanak Institute of Pharmaceutical science and Technology | Mazumder U.K.,Jadavpur University | Haldar P.K.,Jadavpur University | And 2 more authors.
Diabetologia Croatica | Year: 2011

The present study was carried out to evaluate the antihyperglycemic activity of methanol extract of Lagenaria siceraria aerial parts (MELS) for its purported use in diabetes. Hyperglycemia was induced by streptozotocin (50 mg/kg, i.p.) in rats. Treatment was done by MELS at doses of 200 and 400 mg/kg, p.o. for 14 days. Glibenclamide (500 μg/kg) was used as a reference drug. Antihyperglycemic potential was assessed by fasting blood glucose (FBG) measurement (on days 0, 4, 8 and 15), biochemical tests (SGPT, SGOT, ALP, total cholesterol, triglycerides), antioxidant assay (lipid peroxide, catalase and glutathione) and histologic study of the liver, kidney and pancreas tissue. Significant reduction (P<0.001) in FBG levels was observed with treatment duration. Antioxidant and biochemical parameters were significantly improved by MELS and glibenclamide treatment. Histologic observations showed good correlations with the results obtained. The study explored the potent antihyperglycemic activity of MELS, which is probably attributable to its rich flavonoid content. Source


Dewanjee S.,Jadavpur University | Mandal S.C.,Jadavpur University | Sen Gupta A.,Guru Nanak Institute of Pharmaceutical science and Technology
Journal of Pure and Applied Microbiology | Year: 2010

Diarrhoeal diseases are a leading cause of childhood morbidity and mortality in developing countries. Many new microbial causes of diarrhoea have been discovered during the past three decades. The present study was undertaken to evaluate the effect of methanol extract of the fruits of Anus semialata Murr for its antimicrobial potential against bacteria causing diarrhoea. Methanol extract was tested for its minimum inhibitory concentration (MIC) against both Gram-positive and Gram-negative bacteria causing diarrhoea. Further, the zones of inhibition produced by the crude extract against few sensitive strains was measured and compared with those of standard antibiotic ciprofloxacin. It is evident that the methanol extract is very active against the bacteria causing diarrhoea at low concentrations. The antibacterial efficacy of the fruit extract was found to decrease in the following order against different tested bacterial strains like, Escherichia coli, Vibrio cholerae, Shigella boydii, Shigella dysenteriae, Shigella sonnei and Salmonella typhimurium. Source


Saha P.,Jadavpur University | Saha P.,Guru Nanak Institute of Pharmaceutical science and Technology | Bala A.,Jadavpur University | Kar B.,Jadavpur University | And 4 more authors.
Research Journal of Medicinal Plant | Year: 2011

The objective of the present study was to evaluate the antidiabetic activity of methanol extract of aerial parts of Cucurbita maxima (MECM) for its purported use in diabetes. Antidiabetic activity of MECM was evaluated in Wistar albino rats against streptozotocin (50 mg kg-1, i.p.,) at the doses of 200 and 400 mg kg-1, p.o. for 14 days. Glibenclamide (500 μg kg-1) was used as reference drug. Fasting blood glucose (FBG) levels were measured on day 0, 4, 8 and 15. Antioxidant activity of the extract was determined by measuring lipid peroxide, catalase and glutathione (reduced) levels of liver, kidney and pancreas. In addition, biochemical parameters (SGPT, SGOT, ALP) were estimated. Histological study of liver, kidney and pancreas was also performed. FBG levels were reduced in a treatment-duration dependant manner and 60.88, 67.79 and 64.30% reduction with respect to the initial levels were observed on 15th day with low and high dose of MECM and glibenclamide, respectively. The changes in antioxidant and biochemical parameters observed with diabetic control group were reversed towards normal levels with extract and standard treated groups, rlistological observations showed good correlations with other results. The results explored potent antidiabetic activity of the methanol extract of C. maxima aerial parts. © 2011 Academic Journals Inc. Source


Kundusen S.,Jadavpur University | Gupta M.,Jadavpur University | Mazumder U.K.,Jadavpur University | Haldar P.K.,Jadavpur University | And 6 more authors.
Diabetologia Croatica | Year: 2011

The aim of the present study was to evaluate antihyperglycemic activity of methanol extract of Citrus maxima leaf (MECM) in streptozotocin (STZ; 65 mg/kg b.w.) induced diabetic rats. Three days after STZ induction, diabetic rats received MECM orally at a dose of 200 and 400 mg kg -1 body weight daily for 15 days. Glibenclamide (0.5 mg kg -1 p.o.) was used as a reference drug. Blood glucose levels were measured on days 0, 4, 8 and 15. Serum biochemical parameters viz. SGOT, SGPT and ALP were estimated. The TBARS and GSH levels of the pancreas, kidney and liver were determined. MECM significantly (P<0.001) and in a dose dependent manner normalized blood glucose levels, serum biochemical parameters, decreased lipid peroxidation, and recovered GSH as compared to those of STZ control. The present study inferred that in STZ-induced diabetic Wistar rats, C. maxima leaf demonstrated a potential antihyperglycemic effect that might be attributed to its antioxidant property. Source


Saha P.,Jadavpur University | Saha P.,Guru Nanak Institute of Pharmaceutical science and Technology | Kundu Sen S.,Jadavpur University | Bala A.,Jadavpur University | And 2 more authors.
International Journal of Cancer Research | Year: 2011

Cancer is one of the leading causes of mortality worldwide. Many of the cucurbitaceae plants possess antitumor activity. On the basis of traditional use, the present study was carried out to evaluate the anti-cancer activity of methanol extract of Lagenaria siceraria (Mol.) Standley [Cucurbitaceae] aerial parts (MELS) on Ehrlich's Ascites Carcinoma (EAC) model in mice. After inoculation of EAC cells into mice, treatment with MELS (200 and 400 mg kg-1) and standard drug, 5-Fluorouracil (20 mg kg-1) were continued for 9 days. Evaluation of the effect of drug response was made by the study of tumor growth response including increase in life span, study of hematological parameters, biochemical estimations and antioxidant assay of liver tissue. Experimental results revealed that L. siceraria possesses significant anticancer activity which may be due to its cytotoxicity and antioxidant properties. Further research is ongoing to find out the bioactive principle(s) of MELS for its anticancer activity. © 2011 Academic Journals Inc. Source

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