Guru Jambheshwar University of Science and Technology

www.gjust.ac.in
Hisar, India

Guru Jambheshwar University of Science and Technology, Hisar, was founded in 1995. The jurisdiction of the university extends to the courses being run in the areas of science, technology, engineering, pharmacy and management. Wikipedia.

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Singh A.,Guru Jambheshwar University of Science and Technology | Bishnoi N.R.,Guru Jambheshwar University of Science and Technology
Applied Microbiology and Biotechnology | Year: 2012

Cellulase, Tween 80, and β-glucosidase loading were studied and optimized by response surface methodology to improve saccharification. Microwave alkali-pretreated rice straw used as substrate for onsite enzyme production by Aspergillus heteromorphus and Trichoderma reesei. The highest enzymatic hydrolysis (84%) was obtained from rice straw at crude enzyme loading of 10 FPU/gds of cellulase, 0.15% Tween 80, and 100 international unit/g dry solids of β-glucosidase activities. Enzymatic hydrolyzate of pretreated rice straw was used for ethanol production by Saccharomyces cerevisiae, Scheffersomyces stipitis, and by co-culture of both. The yield of ethanol was 0.50, 0.47, and 0.48 g p/g s by S. cerevisiae, S. stipitis, and by co-culture, respectively, using pretreated rice straw hydrolyzate. The co-culture of S. cerevisiae and S. stipitis produced 25% more ethanol than S. cerevisiae alone and 31% more ethanol than S. stipitis alone. During anaerobic fermentation 65.08, 36.45, and 50.31 μmol/ml CO 2 released by S. cerevisiae, S. stipitis, and by co-culture, respectively. The data indicated that saccharification efficiency using optimized crude enzyme cocktail was good, and enzymatic hydrolyzate could be fermented to produce ethanol. © 2012 Springer-Verlag.


Sharma R.,Guru Jambheshwar University of Science and Technology | Ahuja M.,Guru Jambheshwar University of Science and Technology
Carbohydrate Polymers | Year: 2011

The objective of present study was to enhance mucoadhesive potential of pectin by thiolation. Thiolation of pectin was achieved with esterification with thioglycolic acid. Thiolated pectin was characterized by FTIR, DSC, XRD and SEM analysis. Thiolated pectin was determined to possess 0.60 ± 0.04 mmol of thiol groups/g of polymer by Ellman's method. Comparative evaluation of mucoadhesive property of metformin-loaded ionotropically gelled beads of pectin and thiolated pectin by wash off test using goat intestinal mucosa revealed higher ex vivo bioadhesion time of thiolated pectin as compared to pectin. Improved mucoadhesive property of thiolated pectin over the pectin can be attributed to the formation of disulfide bond between mucus and thiolated pectin. In vitro release study conducted using phosphate buffer (pH 6.8) revealed a similar release profile of metformin from pectin and thiolated pectin beads. In conclusion, thiolation of pectin improves its mucoadhesive property without affecting the release profile. © 2011 Elsevier Ltd. All rights reserved.


Kumar A.,Guru Jambheshwar University of Science and Technology | Ahuja M.,Guru Jambheshwar University of Science and Technology
Carbohydrate Polymers | Year: 2012

The objective of the study was to modify gum kondagogu by carboxymethylation and to evaluate it for potential pharmaceutical applications. Carboxymethylation of gum kondagogu was carried out by reacting gum kondagogu with monochloroacetic acid under alkaline conditions. The results of characterization studies revealed that carboxymethylation of gum kondagogu increases its degree of crystallinity and surface roughness, reduces its viscosity and improves its mucoadhesive properties. Further, carboxymethyl gum kondagogu was explored for pharmaceutical applications by formulating ionotropically gelled beads using metformin as the model drug and calcium chloride as cross-linking agent. Ex vivo bioadhesion study conducted using isolated chick-ileum by wash-off test revealed bioadhesion of >80% over a period of 24 h. It was observed that increasing the concentration of cross-linking agent increases the % drug entrapment and reduces the release rate. The beads were found to release the drug by Fickian-diffusion mechanism and following zero-order release kinetics. © 2012 Elsevier Ltd.


Yadav A.,Guru Jambheshwar University of Science and Technology | Garg V.K.,Guru Jambheshwar University of Science and Technology
Bioresource Technology | Year: 2011

This paper reports the recycling of nutrients by vermicomposting of cow dung (CD), poultry droppings (PD) and food industry sludge (FIS) employing earthworms (Eisenia fetida). A total of six vermicomposting units were established and dynamics of chemical and biological parameters has been studied for 13 weeks. The waste mixture containing 50% CD. +. 25% PD. +. 25% FIS had better fertilizer value among studied waste combinations. At the end of experiment, vermicomposts showed decrease in pH and organic C, but increase in EC, total Kjeldhal N, total available P and total K contents. The C:N ratio of final vermicomposts also reduced to 10.7-12.7 from 22.8 to 56 in different waste combinations. The earthworms have good biomass gain and cocoon production in all vermicomposting units but CD alone and 50% CD. +. 25% PD. +. 25% FIS were better than other studied combinations. © 2010 Elsevier Ltd.


Yadav A.,Guru Jambheshwar University of Science and Technology | Garg V.K.,Guru Jambheshwar University of Science and Technology
Bioresource Technology | Year: 2011

This study reports the results of vermicomposting with Eisenia fetida of Parthenium hysterophorus mixed with cow dung in different ratios (25%, 50% and 75%) in a 18weeks experiment. In all the treatments, a decrease in pH, OC total and C:N ratio, but increase in EC, N total, P aval, Ca total, K total and heavy metals was recorded. The cocoons production and growth rate (biomass gain worm -1 day -1) were maximum in 100% cow dung. The results indicated that parthenium can be a raw material for vermicomposting if mix with cow dung in appropriate quantity. © 2011 Elsevier Ltd.


Bansal N.,Guru Jambheshwar University of Science and Technology
Journal of medicinal food | Year: 2010

Phytoestrogens are nonsteroidal plant compounds that are able to exert estrogenic effects. Soybean is a rich source of phytoestrogens, especially isoflavones. Soy isoflavones are utilized for estrogen replacement therapy. Estrogen is reported to influence several areas of brain that are involved in cognition and behavior. Therefore, the present study was undertaken to examine whether dietary supplementation with soybean improves the cognitive function of mice. Soybean was administered in three different concentrations (2%, 5% and 10% [wt/wt]) in the normal diet to young and mature mice for 60 successive days. The passive avoidance paradigm and the elevated plus maze served as the exteroceptive behavioral models, whereas scopolamine (1.4 mg/kg, i.p.) served as the interoceptive behavioral model. The brain acetylcholinesterase activity (AChE) activity, brain thiobarbituric acid-reactive substances (TBARS), reduced glutathione (GSH), and total blood cholesterol levels were also measured in the present study. The administration of soybean for 60 consecutive days protected (P <.05) the animals from developing memory impairment. Soybean administration also resulted in diminished brain AChE activity, decrease in brain TBARS, and increase in GSH levels, thereby indicating facilitated cholinergic transmission, reduced free radical generation, and enhanced scavenging of free radicals. Thus, soybean appears to be a useful remedy for improving memory and for the management of cognitive deficits owing to its pro-estrogenic, antioxidant, procholinergic, and/or neuroprotective properties.


Singh A.,Guru Jambheshwar University of Science and Technology | Bishnoi N.R.,Guru Jambheshwar University of Science and Technology
Bioresource Technology | Year: 2012

Microwave alkali pretreated wheat straw was used for in-house enzyme production by Aspergillus flavus and Trichoderma reesei. Produced enzymes were concentrated, pooled and assessed for the hydrolysis of pretreated wheat straw. Factors affecting hydrolysis were screened out by Placket-Burman design (PBD) and most significant factors were further optimized by Box-Behnken design (BBD). Under optimum conditions, 82% efficiency in hydrolysis yield was observed. After the optimization by response surface methodology (RSM), a model was proposed to predict the optimum value confirmed by the experimental results. The concentrated enzymatic hydrolyzate was fermented for ethanol production by Saccharomyces cerevisiae, Pichia stipitis and co-culture of both. The yield of ethanol was found to be 0.48g p/g s, 0.43g p/g s and 0.40g p/g s by S. cerevisiae, P. stipitis and by co-culture, respectively, using concentrated enzymatic hydrolyzate. During anaerobic fermentation 42.31μmol/mL, 36.69μmol/mL, 43.35μmol/mL CO 2 was released by S. cerevisiae, P. stipitis and by co-culture, respectively. © 2011 Elsevier Ltd.


Jain M.,Guru Jambheshwar University of Science and Technology | Garg V.K.,Guru Jambheshwar University of Science and Technology | Kadirvelu K.,Bharathiar University
Bioresource Technology | Year: 2013

The present study reports the use of sunflower waste carbon calcium-alginate beads (SWC-CAB) for cadmium removal from wastewater in continuous flow fixed bed columns. The experiments were conducted as a function of bed height, flow rate and initial Cd(II) concentration. The maximum biosorption capacity (23.6mg/g) was attained at 30cm bed height, 1.0mL/min flow rate and 10mg/L initial Cd(II) concentration. The Bohart - Adams model constants (N0 and K) were 7.7mg/L and 1×10-4L/mgh with 0.999 R2 value at 50% breakthrough time. The column regeneration efficiency after third cycle was 58.6% for cadmium. © 2012 Elsevier Ltd.


Kirrolia A.,Guru Jambheshwar University of Science and Technology | Bishnoi N.R.,Guru Jambheshwar University of Science and Technology | Singh R.,Guru Jambheshwar University of Science and Technology
Renewable and Sustainable Energy Reviews | Year: 2013

Increasing energy demands, predicted fossil fuels shortage in the near future, and environmental concerns such as the production of greenhouse gas carbon dioxide have motivated the search for alternative and cleaner energy sources. Biodiesel has received much attention in recent years and production of biodiesel from microalgae is a newly emerging field. Microalgae possess a high growth rate, utilize solar light, water and CO2 to convert these to sugars, from which macromolecules, such as lipids and triacylglycerols (TAGs) can be obtained making microalgae more photosynthetically efficient than oil crops. Microalgae are represented as a potential source of biomass, having great biodiversity and variability in their biochemical composition. This paper presents an overview on microalgae with particular emphasis as a source for biofuel and its other applications. Future research and development aspects regarding microalgae and microalgal fuel production are also discussed. © 2012 Elsevier Ltd. All rights reserved.


Singh A.,Guru Jambheshwar University of Science and Technology | Bishnoi N.R.,Guru Jambheshwar University of Science and Technology
Industrial Crops and Products | Year: 2013

Wheat straw is one of the most abundant lignocellulosic feedstocks, contains mixture of sugars, selected for ethanol production. Microwave alkali pretreated wheat straw was used as substrate for ethanol production from Saccharomyces cerevisiae. Optimization of ethanol production from wheat straw enzymatic hydrolyzate was studied using sequential statistical optimization process. First factors affecting ethanol production were screened out by Plackett-Burman design (PBD). Most significant factors pH (4-7), temperature (20-40. °C), initial total reducing sugar conc. (TRS) (1-10%) and inoculum level (1-5%) further studied by Box-Behnken design (BBD) for ethanol production. Maximum ethanol production obtained during BBD was 15.6. g/L with ethanol productivities 0.43. g/L/h. Under optimum conditions ethanol production studied at bioreactor level and obtained ethanol concentration 16.4. g/L with ethanol productivities 0.45. g/L/h obtained at pH 5.5, temperature 30. °C, inoculums level 3.3% and TRS conc. 6.5%. These results indicated that ethanol production can be enhanced by optimization of fermentation conditions. © 2012 Elsevier B.V.

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