Bilaspur, India

Guru Ghasidas University
Bilaspur, India

Guru Ghasidas Vishwavidyalaya , is a Central University of India, located in Bilaspur C.G. State, established under Central Universities Act 2009, No. 25 of 2009. Formerly called Guru Ghasidas University , established by an Act of the State Legislative Assembly, was formally inaugurated on June 16, 1983. GGU is an active member of the Association of Indian Universities and Association of Commonwealth Universities. The National Assessment & Accreditation Council has accredited the University as B+ . Situated in a socially and economically challenged area, the university is appropriately named to honor the great Satnami Saint Guru Ghasidas , who championed the cause of the downtrodden and waged a relentless struggle against all forms of social evils and injustice prevailing in the society.The University is a residential cum affiliating institution, having its jurisdiction spread over Bilaspur Revenue Division of the state of Chhattisgarh. Guru Ghasidas University was formally inaugurated on June 16, 1983 and is one of the two universities in Chhattisgarh State, India. It is in Bilaspur. It was named after Guru Ghasidas, the founder of the Satnami movement in the region. The jurisdiction of the university is spread across the Bilaspur Revenue Division. It covers almost the entire spectrum of the higher education requirements of the local people. It has several University Teaching Department on its campuses. The university is a residential cum affiliating institution. Wikipedia.

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Pal D.,Guru Ghasidas University | Dubey P.,IFTM University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

The aim of this review is to obtain the report regarding beneficial health effects of flavonoids. Flavonoids are phenol substance isolated from a wide range of vascular plants, with over 8000 individual compound known. Flavonoids are secondary plant products.They are mainly found in fruits, vegetables and certain beverages that have diverse beneficial biochemical antioxidant effect. Flavonoids were originally referred to as "vitamin P". Their dietary intake is quite high compared to other dietary antioxidants like vitamins C and E. The major actions of flavonoids are those against cardiovascular diseases, ulcers, viruses, inflammation, osteoporosis, diarrhea and arthritis. Brief description about the disease causing effect of free radicals is given and ways by which flavonoids neutralize free radicals has also been mentioned. The antioxidant activity of flavonoids depends on their molecular structure, and structural characteristics of certain flavonoids found in hops and beer confer surprisingly potent antioxidant activity exceeding that of red wine, tea, or soy. Flavonoids and proanthocyanidins are often found in fruits and vegetables and they powerful anticancer agents. Antioxidants are the compounds that protects cell against the damaging effect of reactive oxygen species, such as singlet oxygen, superoxide, peroxyl radicals and peroxy nitrite. They also can protect LDL stickier and more likely to clog arteries. They also act as an anti-aging.

Lopus M.,Center for Excellence in Basic science | Naik P.K.,Guru Ghasidas University
Pharmacological Reports | Year: 2015

Noscapine and its synthetic derivatives called noscapinoids have been shown to possess potential anticancer properties. These alkaloids target microtubules and inhibit cell proliferation. Noscapinoids are microtubule poisons that induce minor alterations in the innate dynamic instability of microtubules leading to mitotic arrest and cell death. Over the past decade, a number of noscapine derivatives have been synthesized that, compared to the parent compound, show superior anticancer potential, enhanced tumor specificity and tumor regression, and little or no toxicity to normal tissues. Based on their successive synthetic modifications at different points in the scaffold structure of noscapine, aided by computational design and structure-activity relationship studies, the derivatives of noscapine have been classified into different "generations" based on modifications. Several studies have reported the potential to develop noscapinoids as anticancer drugs. Increasing their tumor specificity - either through antibody conjugation or nanoparticle-based carriers - may facilitate the progression of maytansinoid-based cancer drugs to the clinic. © 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

Verma L.,Guru Ghasidas University | Jain N.S.,Guru Ghasidas University
Behavioural Brain Research | Year: 2016

Intrigued by the report demonstrating an increase in brain histamine levels by ethanol administration and central histamine transmission to affect the anxiety related behaviors, the present study examined the permissive role of central histaminergic transmission in the acute anxiolytic-like effect of the ethanol on elevated plus maze (EPM) in mice. Results demonstrated that prior administration of the agents that are known to enhance the brain histamine transmission, i.e. low dose of histamine (0.1 μg/mouse, i.c.v.) or histamine precursor, L-histidine (500, 1000 mg/kg, i.p.) or low dose of histamine releasing agent (H3 receptor inverse agonist), thioperamide (2 μg/mouse) attenuated the acute anitanxiety-like effect of ethanol (2 g/kg, i.p, 8% w/v) in mice on EPM. However, pre-treatment with the H1 receptor antagonist, cetirizine (0.1 μg/mouse, i.c.v.) or H2 receptor antagonist, ranitidine (50 μg/mouse, i.c.v.) failed to affect the attenuating effect of low dose of histamine on ethanol induced anxiolysis. On the other hand, only H1 receptor antagonist, cetirizine (0.1 μg/mouse, i.c.v.) was able to partially reverse the attenuation of ethanol induced anxiolysis by L-histidine (1000 mg/kg, i.p.). Surprisingly, in mice pre-treated with the higher dose of histamine (50 μg/mouse, i.c.v.) or thioperamide (10 μg/mouse, i.c.v.), the ethanol (2 g/kg, i.p.) induced antianxiety-like effect was further enhanced on EPM. Furthermore, this potentiating effect of high dose of histamine on the ethanol (2 g/kg, i.p.) was exacerbated on pre-treatment with the H1 receptor antagonist, cetirizine, while H2 receptor antagonist, ranitidine completely reversed this action of high dose of histamine on ethanol. Supportive to these results, i.c.v. pre-treatment with H1 receptor agonist, FMPH (2, 6.5 μg/mouse, i.c.v.) attenuated while H2 receptor agonist, amthamine (0.1, 0.5 μg/mouse, i.c.v.) enhanced the ethanol induced anxiolysis in mice. Thus, it is reasonable to contemplate that central histaminergic transmission functions to negatively modulate the acute ethanol-induced anxiolysis probably via stimulation of postsynaptic H1 receptor and histamine might contribute to the anxiolytic action of ethanol via H2 receptor activation. © 2016 Elsevier B.V.

Dispersive liquid-liquid microextraction (DLLME) is applied for the determination of copper in cereals and vegetable food samples using flame atomic absorption spectrometry (FAAS). The maximum extraction efficiency of copper was obtained after the optimisation of parameters such as extraction and dispersing solvents, pH, concentration of 2,9-dimethyl-1,10-phenanothroline (DPT), N-phenylbenzimidoyl thiourea (PBITU) and salt. The optimised methodology exhibited a good linearity in the range of 0.2- 20 ng/mL copper with relative standard deviations percentage (RSD,%) from ±1.5% to 3.5%. The method is found to be simple and rapid for the analysis of copper in food samples with the limit of detection (LOD) and quantitation (LOQ) were 0.05 and 0.16 ng/mL, respectively. Good recoveries of copper were obtained in the range of 93.5-98.0% in food samples as well as in Certified Reference Material (99.1%). The application of the proposed method has been successfully tested for the determination of copper in cereals (maize, millet, rice, wheat, gram, lentils, kidney beans and green beans) and vegetable (potato, cauliflower, tomato, spinach, green beans, lettuce, egg plants and bitter gourd) food samples. © 2013 Elsevier Ltd. All rights reserved.

Nayak A.K.,Seemanta Institute of Pharmaceutical science | Pal D.,Guru Ghasidas University
Carbohydrate Polymers | Year: 2014

Fenugreek (Trigonella foenum-graecum L.) seed mucilage (FSM)-gellan gum (GG) mucoadhesive beads containing metformin HCl for oral use were developed through ionotropic-gelation technique. Effects of GG to FSM ratio and cross-linker (CaCl2) concentration on the drug encapsulation efficiency (DEE, %), and cumulative drug release after 10 h (R10h, %) of ionotropically-gelled FSM-GG mucoadhesive beads containing metformin HCl were optimized by 32 factorial design. The optimized mucoadhesive beads showed DEE of 92.53 ± 3.85% and R10h of 55.28 ± 1.58% and mean diameter of 1.62 ± 0.22 mm. The in vitro metformin HCl release from these ionotropically-gelled FSM-GG beads was prolonged over 10 h and followed zero-order model with super case-II transport mechanism. The optimized mucoadhesive beads also exhibited pH-dependent swelling, good mucoadhesivity with biological mucosal membrane and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration. © 2014 Elsevier Ltd. All rights reserved.

Nayak A.K.,Seemanta Institute of Pharmaceutical science | Pal D.,Guru Ghasidas University
International Journal of Biological Macromolecules | Year: 2013

The present study deals with the formulation optimization of jackfruit (Artocarpus heterophyllus Lam., family: Moraceae) seed starch (JFSS)-alginate mucoadhesive beads containing metformin HCl through ionotropic gelation using 32 factorial design. The effect of sodium alginate to JFSS ratio and CaCl2 concentration on the drug encapsulation efficiency (DEE, %), and cumulative drug release at 10h (R10h, %) was optimized. The optimized beads containing metformin HCl showed DEE of 97.48±3.92%, R10h of 65.70±2.22%, and mean diameter of 1.16±0.11mm. The in vitro drug release from these beads was followed controlled-release (zero-order) pattern with super case-II transport mechanism. The beads were also characterized by SEM and FTIR. The swelling and degradation of these beads were influenced by pH of the test medium. The optimized beads also exhibited good mucoadhesivity and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration. © 2013 Elsevier B.V.

Prajapati R.P.,Guru Ghasidas University
Physics Letters, Section A: General, Atomic and Solid State Physics | Year: 2013

The Jeans instability of self-gravitating dusty plasma with polarization force is investigated considering the effects of magnetic field, dust temperature and radiative condensation. The condition of Jeans instability and expression of critical Jeans wave number are obtained which depend upon polarization force and dust temperature but these are unaffected by the presence of magnetic field. The radiative heat-loss functions also modify the Jeans condition of instability and expression of critical Jeans wave number. It is observed that the polarization force and ratio of radiative heat-loss functions have destabilizing while magnetic field and dust temperature have stabilizing influence on the growth rate of Jeans instability. © 2012 Elsevier B.V. All rights reserved.

Jain P.,Guru Ghasidas University
Natural Product Research | Year: 2016

Peptic ulcers are open sores or erosions in the lining of either the duodenum (duodenal ulcers) or the stomach (gastric ulcers). Peptic ulcer, which is mainly caused by bacterial attack or excess of acid secretion, can be cured effectively by these isolated plant compounds. In this present scenario, demand for herbal medicines are increasing due to easy availability in surrounding place at low cost. This review article is all about such isolated plant compounds such as alkaloids, flavonoids and terpenoids. Various plants have been used as folk medicine by the people of rural area, which shows significant effect against peptic ulcer. Further study should be conducted upon these herbal plants because there is possibility for minimising the adverse effect caused by the present antiulcer drugs. © 2015 Taylor and Francis.

Thareja S.,Guru Ghasidas University
Chemical Reviews | Year: 2015

Benign prostatic hyperplasia (BPH) is the noncancerous growth of the prostate gland due to over-proliferation of the stromal and glandular elements of the prostate, resulting in the obstruction of proximal urethra, thus causes urinary flow disturbances. It is caused due to the augmented levels of the androgen dihydrotestosterone (DHT), which plays a key role in prostate growth. In the absence of crystal structure and binding site information, the design of novel inhibitors using a rational designing approach is not possible. Therefore, inhibitors were designed by modifying the structure of natural substrates, including the substitution of one carbon atom of the rings of the steroids by a heteroatom such as nitrogen, thereby forming azasteroids. 2D-QSAR techniques are of particular interest as they eliminate the need for determining 3D structure, putative binding conformation, and molecular alignment.

Sahu S.K.,Guru Ghasidas University
Current drug delivery | Year: 2013

Malaria is one of the major public health problems in the developing countries. Numbers of drugs are available for the treatment of malaria but chloroquine diphosphate still remains a drug of choice. The aim of this study is to develop and characterize a suitable drug delivery system of antimalarial drug for prophylactic use. A depot system for controlled release of antimalarial drug was prepared. Drug loaded heat cross-linked gelatin microspheres were prepared by single emulsion thermal gelation technique. These were characterized by optical microscopy, scanning electron microscopy (SEM), percentage yield (63.20% to 86.13%), drug content (22.95% to 28.02%), encapsulation efficiency (41.46% to 68.26%), differential scanning calorimetry (DSC) and in vitro studies. Sizes of the microspheres as observed by optical microscopy were in the range of 44.06 ± 6.98 μm to 54.70 ± 8.19 μm, DSC pattern showed the absence of drug and polymer interaction. The gelatin microspheres were below 60 μm and spherical in shape as evidenced by the SEM photographs. Encapsulated chloroquine diphosphate was released slowly for 24 ± 1 hrs. The study indicated optimum drug release behavior (84.5% ± 0.96) in 25 hrs.

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