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Guntūr, India

Raman V.L.M.,Guntur Medical College
International Journal of Pharma and Bio Sciences | Year: 2014

The dermatophytosis constitutes a group of superficial fungal infections that infect only superficial keratinized tissues viz. stratum corneum of epidermis, hairs and nails. The infection is commonly designated as ringworm or Tinea. Tinea corporis and Tinea cruris are the clinical forms of dermatophytosis or ringworm infection or Tinea infection. Pruritis is the most common symptom. Typical lesion is usually annular or polycyclic and has a well marginated raised border, composed of multiple erythematous papulovesicles or scales with a clear center Out of 30 patients of Terbinafine group 27 patients have effective treatment in terms of both clinical improvement and mycological cure (i.e., KOH negativity and culture negativity) at the end of 1st week. Out of 30 patients in Clotrimazole group 26 patients have effective treatment in terms of both clinical improvement and mycological cure. (i.e., KOH negativity and culture negativity) at the end of 4th week. The results of the present study suggest that 1 week of 1% Terbinafine applied twice daily is more effective than 4 weeks of 1% Clotrimazole cream applied twice daily. Thus 1% Terbinafine provides rapid relief of symptoms and short duration of therapy for tinea cruris and corporis infections.

Solomon Raju K.,Guntur Medical College
International Journal of Pharma and Bio Sciences | Year: 2014

Congestive Heart Failure (CHF) is one of the most prevalent public health problem of today. CHF is not a disease but a condition that occurs when the heart is unable to pump enough blood to meet the needs of body's tissues. Deficient myocardial Carnitine levels are also involved in the pathogenesis of CHF. Various inotropic drugs, diuretics and vasodilators used in treatment improved the condition of CHF patients to some extent. In this present study, efficacy and safety of Carnitine in CHF is evaluated. It is observed that administration of 2gms of IV L-Carnitine/day improved the condition of CHF patients with beneficial effects characterized by significantly increasing Ejection fraction (P < 0.001). It stimulates the cardiac metabolism and increases the coronary blood flow and decreases ventricular dilation and reduces triglyceride levels significantly (p < 0.001).

Aruna V.,Guntur Medical College | Ambikadevi K.,ASRAM Medical College
International Journal of Pharma and Bio Sciences | Year: 2014

To investigate correlation between Hypomagnesemia and biochemical parameters of atherosclerosis in NIDDM 2.To investigate correlation between serum "C"-peptide levels and glycemic control as evaluated by HbA1c. ASRAM college of Medical Sciences & ASRAM Hospital outpatients and inpatients, Eluru, AP.76 patients of Type II Diabetes Mellitus(NIDDM) aged above 40yrs & 30 number of age & sex matched healthy controls. Serum C-peptide was measured by Direct chemiluminiscence. Fasting Blood Glucose, HbA1c, Serum Total Cholesterol, HDL-C, and Serum Magnesium were considered for analysis and measured using standardized kits from 'Coral clinical systems'.The optical density readings taken in a photoelectric colorimeter. Patients with Hypomagnesemia defined as serum Mg++ <1.6 mg/dl were compared with those having normal serum Mg++ levels (1.6-3.0mg/dl).In the present study inverse relation observed between glycemic control and serum Magnesium levels P-<0.0034.The serum C-Peptide levels showed greater variance in hypomagnesemic diabetic patients compared to normomagnesemic diabetic patients (P <0.012).Strong correlation observed between serum C-Peptide levels and glycemic control with reduced C-Peptide levels in diabetic patients with poor glycemic control (>8%). P<0.00001, The presence of associated complications in diabetic patients showed reduced C-peptide levels,(P-value <0.00001).ANOVA between controls and diabetic patients with hypomagnesemia showed significantly elevated TC/HDLC ratio in diabetic patients with hypomagnesemia (P-<0.026).The present study concluded with the principal observation that glycemic control and reduced C-Peptide levels influenced hypomagnesemia. Deleterious effects of dyslipidemia of Diabetes Mellitus per se were exacerbated by hypomagnesemia and reduced C-Peptide levels.

Dakshina Murthy P.,Geetha Nursing Home | Thukaram Prasad K.,Devi Nursing Home | Venu Gopal P.,Geetha Nursing Home | Vasudeva Rao K.,Guntur Medical College | Murali Babu Rao R.,Guntur Medical College
Journal of Association of Physicians of India | Year: 2012

Objectives: The present cross-sectional community-based study was conducted to assess the prevalence and risk factors for coronary artery disease (CAD) in an urban community in Tenali, Andhra Pradesh. Methods: A survey was carried out in two localities of Tenali town, Andhra Pradesh (A.P) namely Gandhinagar and Nazarpet between July 2009 and October 2009. A total of 534 people aged 20 years and above in randomly selected houses in each street of the 2 localities were examined. All of them underwent oral glucose tolerance test and lipid profile estimation and a 12-lead electrocardiogram. CAD was diagnosed based on previous medical history and documented myocardial infarction and/or coronary intervention procedures or Minnesota coding of ECGs. Results: The overall prevalence rate of CAD was 5.4% (age standardized prevalence rate = 5.1%). The prevalence rate of CAD were 3.0%, 23.5% and 11.3% in persons with normal glucose tolerance impaired glucose tolerance and diabetes mellitus respectively. Prevalence of CAD increased with an increase in total cholesterol (P<0.01), serum triglycerides (P<0.01) low density lipoprotein (LDL) cholesterol (P<0.01) and total cholesterol/high density lipoprotein cholesterol ratio (P <0.01). Multiple logistic regression analysis identified age (odds ratio O.R.1.068, P=0.0001), LDL Cholesterol (O.R. 0.98, P=0.03), total cholesterol (O.R.1.107, P=0.059) had a significant association with CAD. Conclusions: Observations from our community based study indicate that prevalence of CAD in urban Andhra Pradesh is alarmingly high as observed in other parts of India and urgent steps are to be taken to adopt life style changes and to control risk factors. © Japi.

Amalakanti S.,Guntur Medical College | Pentakota M.R.,Guntur Medical College
Respiratory Care | Year: 2016

BACKGROUND: Measurement of oxygen saturation with a handheld pulse oximeter is widely practiced as a surrogate to invasive arterial blood gas analysis. Oxygen saturation is an important parameter in cases of COPD, but there are insufficient data on the role of pulse oximetry in patients with COPD, moreso in diseases across its spectrum, such as chronic bronchitis and emphysema. We assessed the performance of pulse oximetry in acute respiratory failure of patients with COPD. METHODS: This was a cross-sectional, observational study. We studied 50 subjects with COPD admitted to the Government General Hospital, a 1,000-bed tertiary referral center in Guntur, India, from June 2013 to July 2013. Simultaneous reading of SpO2 by a handheld pulse oximeter and SaO2 by an automated arterial blood gas analyzer were taken. RESULTS: Pulse oximetry was sufficiently sensitive (84.60%) to hypoxemia in respiratory failure to be used in clinical situations. The mean difference (bias) between SaO2 and SpO2 was –3.98 (95% CI –4.68 to 3.28). There was less sensitivity (82% vs 85%) and positive predictive value (69% vs 85%) of the pulse oximeter to respiratory failure in subjects with chronic bronchitis versus emphysema. CONCLUSIONS: Pulse oximetry performed poorly in comparison with the invasive arterial blood gas analysis. The variability of the readings was greater in the subjects with chronic bronchitis than in those with emphysema. © 2016 Daedalus Enterprises.

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