Gulhane Medical Faculty Training Hospital

Ankara, Turkey

Gulhane Medical Faculty Training Hospital

Ankara, Turkey
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Naharci I.,Gulhane Medical Faculty Training Hospital | Bozoglu E.,Gulhane Medical Faculty Training Hospital | Karadurmus N.,Gulhane Medical Faculty Training Hospital | Emer O.,Gulhane Medical Faculty Training Hospital | And 4 more authors.
Archives of Gerontology and Geriatrics | Year: 2012

The knowledge about vitamin B 12 and folic acid levels in preserving bone mass in older men is limited. In this retrospective study, we aimed to find out whether levels of vitamin B 12 and folic acid are related to BMD in older men. Two hundred and sixty-nine older men were included in the study. Forty-two (15.6%) of them had osteoporotic, 150 (55.8%) had osteopenic, and 77 (28.6%) had normal BMD. Vitamin B 12 and folic acid levels were categorized as indicating normal, borderline, or low vitamin statuses. Femur neck densities showed statistically significant differences in subjects having low, borderline, and normal vitamin B 12, respectively. There were no significant differences between the three tertiles of vitamin B 12 in femur total, trochanteric, and intertrochanteric densities. After adjustment for age, body mass index (BMI), alcohol, smoking, and exercise with analysis of covariance, the difference was still statistically significant between two groups for femur neck density (p=0.011). No significant difference was observed between the groups of folic acid in any femur sites. We found that the normal level of vitamin B 12 in older men may be related to a decrease of femur neck bone loss. © 2011 Elsevier Ireland Ltd.


Naharci I.,Gulhane Medical Faculty Training Hospital | Bozoglu E.,Gulhane Medical Faculty Training Hospital | Kocak N.,Gulhane Medical Faculty Training Hospital | Doganci S.,Gulhane Medical Faculty Training Hospital | And 2 more authors.
Geriatrics and Gerontology International | Year: 2012

Aim: Recent data has shown that vitamin D increases insulin sensitivity; however, there is little evidence about the effects of this treatment on elderly people with impaired fasting glucose. The aim of the present study was to investigate the effect of vitamin D treatment on insulin sensitivity and metabolic parameters in elderly people with impaired fasting glucose. Methods: A total of 28 elderly patients were enrolled into the vitamin D treatment group. The control group included 23 age-, sex- and body mass index-matched elderly participants. The vitamin D treatment group was treated with vitamin D3 according to serum concentrations of 25(OH)D. Results: With supplementation, 96.0% of patients achieved a mean serum 25(OH)D concentration of 123.2±59.9nmol/L. After 4.7±2.5months of treatment, there was a significant decrease in homeostasis model assessment of insulin resistance, insulin and glucose concentrations in the vitamin D treatment group (P=0.007, P=0.007, P=0.037, respectively). Vitamin D treatment significantly increased high-density lipoprotein cholesterol (P=0.037), but did not cause statistically significant differences in other lipid parameters. Conclusion: We found that vitamin D treatment might modify insulin sensitivity in the elderly with impaired fasting glucose. © 2011 Japan Geriatrics Society.


PubMed | Gulhane Medical Faculty Training Hospital
Type: Journal Article | Journal: Archives of gerontology and geriatrics | Year: 2012

The knowledge about vitamin B(12) and folic acid levels in preserving bone mass in older men is limited. In this retrospective study, we aimed to find out whether levels of vitamin B(12) and folic acid are related to BMD in older men. Two hundred and sixty-nine older men were included in the study. Forty-two (15.6%) of them had osteoporotic, 150 (55.8%) had osteopenic, and 77 (28.6%) had normal BMD. Vitamin B(12) and folic acid levels were categorized as indicating normal, borderline, or low vitamin statuses. Femur neck densities showed statistically significant differences in subjects having low, borderline, and normal vitamin B(12), respectively. There were no significant differences between the three tertiles of vitamin B(12) in femur total, trochanteric, and intertrochanteric densities. After adjustment for age, body mass index (BMI), alcohol, smoking, and exercise with analysis of covariance, the difference was still statistically significant between two groups for femur neck density (p=0.011). No significant difference was observed between the groups of folic acid in any femur sites. We found that the normal level of vitamin B(12) in older men may be related to a decrease of femur neck bone loss.


PubMed | Gulhane Medical Faculty Training Hospital
Type: Journal Article | Journal: Geriatrics & gerontology international | Year: 2012

Recent data has shown that vitamin D increases insulin sensitivity; however, there is little evidence about the effects of this treatment on elderly people with impaired fasting glucose. The aim of the present study was to investigate the effect of vitamin D treatment on insulin sensitivity and metabolic parameters in elderly people with impaired fasting glucose.A total of 28 elderly patients were enrolled into the vitamin D treatment group. The control group included 23 age-, sex- and body mass index-matched elderly participants. The vitamin D treatment group was treated with vitamin D(3) according to serum concentrations of 25(OH)D.With supplementation, 96.0% of patients achieved a mean serum 25(OH)D concentration of 123.2 59.9 nmol/L. After 4.7 2.5 months of treatment, there was a significant decrease in homeostasis model assessment of insulin resistance, insulin and glucose concentrations in the vitamin D treatment group (P = 0.007, P = 0.007, P = 0.037, respectively). Vitamin D treatment significantly increased high-density lipoprotein cholesterol (P = 0.037), but did not cause statistically significant differences in other lipid parameters.We found that vitamin D treatment might modify insulin sensitivity in the elderly with impaired fasting glucose.

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