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Korkmaz C.,Center for Assisted Reproduction Technologies and | Cinar O.,Etlik Zubeyde Hanim Womens Health Teaching and Research Hospital | Akyol M.,Gulhane Military Medical Faculty
Gynecological Endocrinology | Year: 2011

Meiotic spindle analysis with a non-invasive technique, the PolScope, is used to protect the meiotic spindle from damage during microinjection. To evaluate the predictive feature of PolScope, we have designed a retrospective study to analyse the correlation between the meiotic spindle visualisation with regard to spindle location and outcomes of assisted reproductive technologies (ART), including patient age, previous cycles, the number of the collected oocytes, fertilisation rates (FR), pronuclear scoring (PNS) and embryo scoring of the days from two to five. All of the data belonging to 1496 oocytes from 190 patients were statistically analysed. We found that the oocytes having PolScope visualised spindle have higher FR, and also observed that when the spindle located at 0°30° according to the first polar body, gave the highest FR. PNS gave higher scores in the spindle visualised group, but spindle angle did not affect PNS outcomes. Although a correlation was found between spindle visualisation and developed embryo qualities, particularly at day 2 and 3, spindle angles did not affect embryo quality. We conclude that PolScope microscopy has an efficiency to estimate FR, and cleavage stage embryo development. © 2011 Informa UK, Ltd.

Esen A.,Medical Park Hospital | Dolanmaz D.,Selcuk University | Kalayci A.,Selcuk University | Gunhan O.,Gulhane Military Medical Faculty | Avunduk M.C.,Selcuk University
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology | Year: 2010

Localized Langerhans cell histiocytosis (LLCH), formerly known as eosinophilic granuloma, mainly affects the skull, mandible, vertebrae, and ribs in children and the long bones of adults. Symptoms range from none to pain, swelling, and tenderness over the site of the lesion. General malaise and fever occasionally are present. Radiographically, lesions appear as radiolucent areas with well demarcated borders. LLCH may resolve spontaneously after biopsy in a period of months to years. However, if features include continuous pain, decrease of function, pathologic fractures, migration and resorption of teeth, or rapid progression, then active treatment needs to be considered. Treatment approaches include surgery, radiotherapy, chemotherapy, and intralesional injection of corticosteroids. In children with mandibular LLCH, 1 dose of methyprednisolone succinate injection has proven to be adequate. However, injections have not been performed in cases involving pathologic fracture. We report a new case of LLCH of the mandible that caused a pathologic fracture in an adult patient. Repeated intralesional corticosteroid injections resulted in fracture line disappearance within 14 months and lesion healing by the end of the 36-month follow-up. © 2010 Mosby, Inc. All rights reserved.

Arici C.,Gulhane Military Medical Faculty
Journal of AAPOS | Year: 2012

Purpose: To compare the effectiveness of superior oblique tuck and inferior oblique weakening procedures on objective and subjective torsion in patients with superior oblique palsy. Methods: Patients with unilateral superior oblique palsy evaluated between September 2007 and October 2009 were treated with one of four surgical procedures on the basis of their preoperative findings: superior oblique tuck, anterior transposition of the inferior oblique muscle, inferior oblique recession, or inferior oblique myectomy. Subjective (double Maddox rods) and objective (fundus photography) torsion were measured pre- and postoperatively. Results: A total of 28 patients were evaluated (mean age, 16.4 ± 12.4 years; range, 6-51 years). In 15 (53.6%) the superior oblique palsy was congenital; in 13 (46.4%) it was acquired. The mean decrease in subjective extorsion was 6.2°± 2.3°after superior oblique tuck, 2.3°± 2.4°after anterior transposition of the inferior oblique, 1.3°± 2.7°after inferior oblique recession, and 2.6°± 4.7°after inferior oblique myectomy. Objective extorsion decreased by 5.8°± 0.8°, 4.4°± 1.7°, 3.1°± 3.2°, and 3.4°± 4.7°, respectively. Conclusions: Superior oblique tuck appears to correct extorsion more effectively than inferior oblique surgery, but this may be an artifact of performing tucks in patients with greater initial extorsion. The small amount of extorsion correction was similar for all inferior oblique procedures. © 2012 by the American Association for Pediatric Ophthalmology and Strabismus.

Ogur R.,Gulhane Military Medical Faculty
Environmental Earth Sciences | Year: 2011

Pesticides and nitrites which could be available in foods are generally investigated individually, although they could be found in foods together and exhibit combined health effects. In this study we aimed to determine the combined effects of endosulfan which is a commonly used pesticide and N-nitroso-N-methylurea (NMU) which is a prototype for mammary tumor development in Sprague Dawley rats and could be formed in brine foods or also in body from nitrites which is commonly used in meat. Ninety female Sprague Dawley rats had been used. Animals were divided three groups which consisted 30 animals. The first group took a single dose endosulfan intraperitoneal (ip) on 19th day and a single dose NMU ip on 21 day, the second group took endosulfan by their drinking waters for the first 60 days of their life and a single dose NMU ip on 21 day, and the third group took only a single dose NMU ip on 21 day. Animals were controlled for their general health status, mammary mass develeopment, daily water consumption and weekly weight gain. At the end of the study rats were examinated carefully under anesthesia, and tissue samples were prepared from their mammary glands and intraabdominal organs. Tissue samples taken from mammary glands, liver and kidneys were histopathalogically examined. It was determined a statistically significant hepatomegally in the second group when we compared to other groups (p < 0.05). No animals developed mammary tumors. On the macroscopic examination and manual palpation of intraabdominal region, it was showed that solid tumors in kidneys as a ratio of 76.7% of the animals in the second group (bilateral in 1,3% of them, the others are unilaterally and 70% of the unilateral tumors are in the left kidneys while the rest of them are right localized). Also it was found that in the first group, 13.4% of the animals developed unilateral kidney tumors. The third group which had been applied only NMU developed no kidney or liver pathalogy macroscopically. As a result it was considered that a diversity which is named as "genetic shift" could be developed in our animal research center and because of this shift we could not developed NMU induced mammary tumors in our Sprague Dawley rats. But it has been showed that long term endosulfan expose has resulted in kidney tumor development for the first time. Because of the genetic shifting mentioned above, it should be tested whether this experimental animal cancer model is limited for our research center or not by obtaining sprague dawley animals from different centers. Interactions of living style, environmental factors and genetic properties in the development of cancer and its necessary to control all of three factors in order to reduce cancer frequency in public showed that the importance of interdiciplinary collaboration and public education. Consumers and appliers should be educated about using pestices, and healthy and safety food production and concumption should be considered as one of the primary subjects in public health studies. © Springer-Verlag Berlin Heidelberg 2011.

Yorbik O.,Gulhane Military Medical Faculty | Kurt I.,Gulhane Military Medical Faculty | Hasimi A.,Gulhane Military Medical Faculty | Ozturk O.,Gulhane Military Medical Faculty
Biological Trace Element Research | Year: 2010

Although potentially harmful effects of heavy metals are well known, limited numbers of studies exist regarding their relationship with autism. The aim of this study was to investigate urine levels of some heavy metals such as of chromium (Cr), cadmium (Cd), and lead (Pb) in children with autism and healthy subjects. Urine levels of Cr, Cd, and Pb were measured by atomic absorption spectrometry in 30 children with autism and compared with 20 healthy controls. Urine Cd and Pb levels were found as significantly decreased in children with autism compared to healthy subjects (p<0.05). On the other hand, urine Cr levels were significantly higher in children with autism than healthy subjects (p<0.05). This study suggested that autism may be associated with significant decrease in excretion rate of Cd and Pb and a significant increase excretion rate in the levels of Cr in the urine. These results have indicated that further studies are warranted for investigation of possible roles of heavy metals in autism. © 2009 Humana Press Inc.

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