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Ahmadabad, India

Gujarat University is a state university situated at Ahmedabad, Gujarat state, India. It is an affiliating university at the under-graduate level and a teaching one at the postgraduate level. It is accredited B++ by NAAC. Wikipedia.

Jadeja R.N.,Gujarat University
Asian Pacific journal of tropical medicine | Year: 2012

Present review for the first time provides a complete botanical description and information on ethnomedicinal uses of Clerodendron glandulosum.Coleb (CG; Fam, Verbenaceae). Recent studies conducted from our laboratory provide pharmacological evidence for its anti-hypertensive, anti-diabetic and anti-obesity potentials. Further, its beneficial potential in preventing in vitro and in vivo non-alcoholic steatohepatitis and atherosclerosis and potent hepatoprotective and free radical scavenging abilities along with its acute and sub-chronic toxicological evaluations are also reported from our laboratory. In keeping with its traditional uses, CG extract was capable of ameliorating experimentally induced hypertension, diabetes and obesity. Its beneficial potential against NASH induced oxidative stress and atherosclerosis can be attributed to its potent free radical scavenging potential. Non-toxic nature of CG leaf extract further provides added merit to its reported pharmacological properties. The present review summarizes the pioneering scientific evidence for the pharmacological effects of CG against related metabolic disorders like hypertension, diabetes and obesity along with anti oxidant potential and beneficial effects against non alcoholic steatohepatitis. Copyright © 2012 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

Kharadi G.J.,Gujarat University
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2013

New Fe(III) complexes have been synthesized by the reactions of ferric nitrate with Schiff base derived from 3-substituted phenyl-4-amino-5-hydrazino- 1,2,4-triazole and indoline-2,3-dione. All these complexes are soluble in DMF and DMSO; low molar conductance values indicate that they are non-electrolytes. Elemental analyses suggest that the complexes have 1:1 stoichiometry of the type [FeLn(H2O)(OH)]xH2O. Structural and spectroscopic properties have been studied on the basis of elemental analyses, infrared spectra, 1H and 13H NMR spectra, electronic spectra, magnetic measurements and FAB mass spectra. FT-IR, 1H and 13H NMR studies reveal that the ligand (Ln) exists in the tautomeric enol form in both the states with intramolecular hydrogen bonding. Magnetic moment and reflectance spectral studies reveal that an octahedral geometry has been assigned to all the prepared complexes. FRAP values indicate that all the compounds have a ferric reducing antioxidant power. The compounds 2 and 3 showed relatively high antioxidant activity while compound 1 and 4 shows poor antioxidant power. Also good antimicrobial activities of the complexes against Staphylococcus aureus, Bacillus subtilis, Serratia marcescens, Pseudomonas aeruginosa and Escherichia coli have been found compared to its free ligands. © 2013 Elsevier B.V. All rights reserved.

Kharadi G.J.,Gujarat University
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2014

An octahedral complexes of copper with clioquinol(CQ) and substituted terpyridine have been synthesized. The Cu(II) complexes have been characterized by elemental analyses, thermogravimetric analyses, magnetic moment measurements, FT-IR, electronic, 1H NMR and FAB mass spectra. Antimycobacterial screening of ligand and its copper compound against Mycobacterium tuberculosis shows clear enhancement in the antitubercular activity upon copper complexation. Ferric-reducing anti-oxidant power of all complexes were measured. The fluorescence spectra of complexes show red shift, which may be due to the chelation by the ligands to the metal ion. It enhances ligand ability to accept electrons and decreases the electron transition energy. The antimicrobial efficiency of the complexes were tested on five different microorganisms and showed good biological activity. © 2013 Elsevier B.V. All rights reserved.

It is a continuing quest to uncover the principal molecular targets of malarial parasites to understand the antimalarial activity and mechanism of action of artemisinin, a potent antimalarial. A series of parasite proteins are experimentally validated as potential targets, such as translationally controlled tumor protein (TCTP) and sarco/endoplasmic reticulum membrane calcium ATP-ase (SERCA). The present study addressed the development of a theoretical model of Plasmodium falciparum NADH dehydrogenase with inference from artemisinin in vivo inhibitory activity. We report here the predicted binding modes of artemisinin and its derivatives. The modeled protein resembled the structural architecture of flavoproteins and oxidoreductases, consisting of two Rossmann folds and dedicated binding sites for its cofactors. Docked poses of the ligand dataset revealed its interactions at or near the si face, indicating being activated. This may aid in generation of reactive oxygen species, thereby disrupting the membrane potential of parasite mitochondria and leading to the clearance from the blood. These observations open up new strategies for development of novel therapeutics, or improvement of existing pharmacotherapies against malaria, a major burden for global health.

We developed a new, advanced, simple and non enzymatic approach for the colorimetric detection of glucose based on calix[4]arene/phenyl boronic acid (CX-PBA)functionalized gold nanoparticles (AuNPs). This molecular receptor proficiently and selectively recognizes glucose due to its ability to reversibly bind diol-containing compounds. The assembly was characterized by transmission electron micrograph (TEM), dynamic light scattering (DLS), UV-Vis, FT-IR, ESI-MS and (1)H NMR spectrometry, which demonstrates the binding affinity for glucose via a boronic acid-diol interaction. The linear range for glucose was found to be 5-100 nM with phosphate buffer pH 10, with a lower detection limit of 4.3 nM. Interference by other saccharides was negligible. The biosensor has been successfully applied to estimate the glucose in human blood serum samples and the results compared well to an automatic analyzer. With the advantages of high sensitivity, selectivity and low sample volume, this method is potentially suitable for the on-site monitoring of glucose.

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