Gujarat Liqui Pharmacaps Pvt. Ltd.

Vadodara, India

Gujarat Liqui Pharmacaps Pvt. Ltd.

Vadodara, India
SEARCH FILTERS
Time filter
Source Type

Ghodasara R.,Parul Institute of Pharmacy and Research | Garala R.,Parul Institute of Pharmacy and Research | Patel K.,Gujarat Liqui Pharmacaps Pvt. Ltd
International Journal of Pharmaceutical Research | Year: 2015

In the present research work, aimed to prepare and evaluate the fast dissolving oral films containing Cyproheptadine hydrochloride, an antihistaminic drug using different ratios of polymer Hydroxypropyl methylcellulose E5 and plasticizer PEG 400. The film was prepared by solvent casting technique using citric acid, sucralose and menthol as saliva stimulating agent, sweetening and cooling agent respectively. The study examines the influence of polymers to plasticizer ratio on physicochemical properties and drug release potential of films. Cyproheptadine hydrochloride is first generation antihistaminic and bind with specifically H1-receptor at nerves ending.which has low oral bioavailability due to hepatic first pass metabolism. The present study investigated the possibility of developing Cyproheptadine hydrochloride fast dissolving oral films allowing fast, reproducible drug dissolution in the oral cavity, thus bypassing first pass metabolism to provide rapid onset of action of the drug. The films were thin, smooth, flexible, and uniform in drug content, weight and thickness as observed from low SD values. The film formulation, (F5) consisting of 300mg of HPMC E5 and 20% PEG 400 was found to be suitable in the form of fast dissolving oral film based on in vitro evaluation studies. The optimized formulation, F5 showed less disintegration time and faster drug release. All the systems were found to be stable with respect to drug content as well as physical changes at 30°C and 65% RH and 40°C and 75% RH. The results suggest that polymer based fast dissolving films are potential means to achieve rapid drug release for effective therapy. © 2015, Association of Indian Pharmacist. All rights reserved.


Lodha A.,Gujarat Liqui Pharmacaps Pvt. Ltd. | Lodha A.,University of Greenwich | Lodha M.,University of Greenwich | Patel A.,Gujarat Liqui Pharmacaps Pvt. Ltd. | And 4 more authors.
Journal of Pharmacy and Bioallied Sciences | Year: 2012

Mesoporous silica nanoparticles (MSNs) are introduced as chemically and thermally stable nanomaterials with well-defined and controllable morphology and porosity. It is shown that these particles possess external and internal surfaces that can be selectively functionalized with multiple organic and inorganic groups. Silica nano-particles were synthesized by chemical methods from tetraethylorthosilicate (TEOS), methanol (CH3OH) and deionised water in the presence of sodium hydroxide as catalyst at 80C temperature. The nature and morphology of particles was investigated by scanning electron microscopy (SEM), N2 adsorption/desorption method using BET instrument and X-ray diffraction (XRD). Silica nanoparticles are applicable to a wide range of therapeutic entities from small molecule to peptides and proteins including hydrophobic and hydrophilic entities. Drug loading does not require chemical modification of the molecule; there are no changes in the drug structure or activity after loading and subsequent release of the drug. Thus, well suited to solve formulation problems associated with hydrophobic drugs such as peptide and protein drugs like cyclosporine A. Silica nanoparticles improved the solubility of poorly water soluble drugs and enhanced the absorption and bioavailability of these compounds.


Patel A.,Gujarat Liqui Pharmacaps Pvt. Ltd. | Lodha A.,Gujarat Liqui Pharmacaps Pvt. Ltd. | Chaudhuri J.,Gujarat Liqui Pharmacaps Pvt. Ltd. | Jadia P.,Gujarat Liqui Pharmacaps Pvt. Ltd. | And 2 more authors.
Journal of Pharmacy and Bioallied Sciences | Year: 2012

Artemether and Lumefantrine capsules are indicated for the treatment of P. falciparum malaria cases resistant to both chloroquine and sulphadoxine, pyrimethamine combination. Both artemether and lumefantrine act as blood schizontocides. Artemether is a sesquiterpene lactone derived from artemisinin. Artemisinin is a compound derived from the sweet wormwood plant and has been used for centuries in traditional Chinese medicine to treat fever. Lumefantrine is a synthetic aryl-amino alcohol antimalarial (quinine, mefloquine and halofantrine are members of the same group). Artemether is absorbed fairly rapidly with peak plasma concentrations reached about 2 hours after dosing. Absorption of lumefantrine, a highly lipophilic compound, starts after a lag period of up to 2 hours, with peak plasma concentration about 6-8 hours after dosing. In order to overcome this problem, we have observed that when the drug is given in the soft gelatin dosage form, the bioavailability of the drug is increased. Thus, increasing the absorption of the drug and peak plasma concentration is reached earlier then the conventional dosage form.


Lodha A.,Gujarat Liqui Pharmacaps Pvt. Ltd. | Patel A.,Gujarat Liqui Pharmacaps Pvt. Ltd. | Chaudhuri J.,Gujarat Liqui Pharmacaps Pvt. Ltd. | Jadia P.,Gujarat Liqui Pharmacaps Pvt. Ltd. | And 2 more authors.
Journal of Pharmacy and Bioallied Sciences | Year: 2012

The compound ibuprofen, 2-(4-isobutylphenyl) propionic acid, has been known e.g. from Martindale, the Extra Pharmacopoeia, 28 th edition, 1982, p.256, as a drug which had anti-inflammatory and analgesic properties. It is used for the treatment of rheumatoid arthritis or other inflammatory diseases of joints, soft tissue rheumatism and gout. Ibuprofen, because of its analgesic properties, has been widely used as anodyne, e.g. against pain or discomfort associated with headache, toothache or menstruation. A medication suitable to combat acute pain is demanded to display its effects fast which action, in turn, is only achieved by a quick release and good bio-availability of the active-ingredient. It is for the commercial forms in particular that the conditions of preparation must be strictly observed, as minor alterations in production procedures such as mixing, pressure of compression and type of machine will affect the physical properties of the particles of he active ingredient and will deteriorate its bio-availability. It is an object of this presentation to provide a medicament that can be readily taken that contains an active amount of ibuprofen in a carrier, that is simple to prepare and that will quickly display a high activity.


PubMed | Gujarat Liqui Pharmacaps Pvt. Ltd.
Type: Journal Article | Journal: Journal of pharmacy & bioallied sciences | Year: 2012

The compound ibuprofen, 2-(4-isobutylphenyl) propionic acid, has been known e.g. from Martindale, the Extra Pharmacopoeia, 28(th) edition, 1982, p.256, as a drug which had anti-inflammatory and analgesic properties. It is used for the treatment of rheumatoid arthritis or other inflammatory diseases of joints, soft tissue rheumatism and gout. Ibuprofen, because of its analgesic properties, has been widely used as anodyne, e.g. against pain or discomfort associated with headache, toothache or menstruation.A medication suitable to combat acute pain is demanded to display its effects fast which action, in turn, is only achieved by a quick release and good bio-availability of the active-ingredient. It is for the commercial forms in particular that the conditions of preparation must be strictly observed, as minor alterations in production procedures such as mixing, pressure of compression and type of machine will affect the physical properties of the particles of he active ingredient and will deteriorate its bio-availability. It is an object of this presentation to provide a medicament that can be readily taken that contains an active amount of ibuprofen in a carrier, that is simple to prepare and that will quickly display a high activity.


PubMed | Gujarat Liqui Pharmacaps Pvt. Ltd.
Type: Journal Article | Journal: Journal of pharmacy & bioallied sciences | Year: 2012

Artemether and Lumefantrine capsules are indicated for the treatment of P. falciparum malaria cases resistant to both chloroquine and sulphadoxine, pyrimethamine combination. Both artemether and lumefantrine act as blood schizontocides. Artemether is a sesquiterpene lactone derived from artemisinin. Artemisinin is a compound derived from the sweet wormwood plant and has been used for centuries in traditional Chinese medicine to treat fever. Lumefantrine is a synthetic aryl-amino alcohol antimalarial (quinine, mefloquine and halofantrine are members of the same group). Artemether is absorbed fairly rapidly with peak plasma concentrations reached about 2 hours after dosing. Absorption of lumefantrine, a highly lipophilic compound, starts after a lag period of up to 2 hours, with peak plasma concentration about 6-8 hours after dosing. In order to overcome this problem, we have observed that when the drug is given in the soft gelatin dosage form, the bioavailability of the drug is increased. Thus, increasing the absorption of the drug and peak plasma concentration is reached earlier then the conventional dosage form.

Loading Gujarat Liqui Pharmacaps Pvt. Ltd. collaborators
Loading Gujarat Liqui Pharmacaps Pvt. Ltd. collaborators