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Patel U.H.,Sardar Patel University | Barot R.A.,Sardar Patel University | Patel B.D.,Nv Patel Pure And Applied Science College | Shah D.A.,Mg Science Institute | Modh R.D.,Gujarat Arts and Science College
Agris On-line Papers in Economics and Informatics | Year: 2012

N-substituted pyrrole derivatives block HIV fusion. Docking used for virtual screening of database and for the prediction of the strongest binders based on various scoring functions. Docking studies were carried out on different pyrrole derivatives for better anti-HIV-1 activity which is important for the development of a new class of inhibitors. Protein-ligand interaction plays an important role in structural based drugs design. In our research we have selected different receptor which shows anti-HIV-1 activity. The receptors were docked with different pyrrole derivatives and the energy value obtained. Our study reveals that the highest energy values observed for all the three ligands are with 3MNW: for 2-Amino-1-(4-Iodophenyl)-oxo-4, 5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester energy value is -265.9, for 2-Amino-1-(4-Fluoro-phenyl)-oxo-4, 5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester energy value is -228.23 and for 2-Amino-1-(4-Methoxy-phenyl)-oxo-4, 5-dihydro-1Hpyrrole-3-carboxylic acid ethyl ester energy value is -227.13. From this we can say that Iodo pyrrole derivative shows high interaction energy compared to other Fluoro and methyl derivatives. By synthesizing few more analogous, we can further improve the interaction energy values and hence better analogous derivatives can be predicted. © 2010.


Patel R.M.,Gujarat Arts and Science College | Deheri G.M.,Sardar Patel University | Vadher P.A.,Government Science College
Tribology in Industry | Year: 2010

Efforts have been made to study and analyze the effect of transverse surface roughness on the performance of a magnetic fluid based squeeze film between triangular plates. The roughness of the bearing surfaces is characterized by a stochastic random variable with non-zero mean variance and skewness. The associated Reynolds' equation is stochastically averaged with respect to the random roughness parameter in turn, which is solved with appropriate boundary conditions to obtain the pressure distribution. From this, the expression for load carrying capacity is derived. The results suggest that the magnetization parameter increases the load carrying capacity while the load carrying capacity gets decreased due to the standard deviation. It is seen that the negatively skewed roughness increases the load carrying capacity substantially especially, when the negative variance is involved. It is revealed that the negative effect induced by the standard deviation can be minimized by the positive effect of the magnetization parameter in the case of negatively skewed roughness.


Deheri G.M.,Sardar Patel University | Patel R.M.,Gujarat Arts and Science College
Meccanica | Year: 2010

An endeavor has been made to discuss the behavior of hydromagnetic squeeze film between two conducting rough porous conical plates. The plates are considered to be electrically conducting and the clearance space between them is filled by an electrically conducting lubricant. A transverse magnetic field is applied between the plates. Efforts have been made to solve the concerned Reynolds' equation with the associated boundary conditions to get the pressure distribution. This in turn, is used to obtain the expression for load carrying capacity leading to the calculation of the response time. The results are presented graphically as well as in tabular form. It is suggested by the results that the bearing system records an enhanced performance as compared to that of a bearing system working with a conventional lubricant. It is noticed that the pressure, load carrying capacity and the response time increase steadily with increasing values of the magnetization parameter. In general, the bearing suffers owing to transverse surface roughness. However, the negatively skewed roughness tends to better the performance of the bearing system marginally. This performance gets further improved especially, when the negative variance is involved. It is observed that the semi-vertical angle increases the load carrying capacity. Besides, the conductivity also increases the load carrying capacity significantly. In addition, it is revealed that the negative effect induced by the porosity can be neutralized to a nominal extent by the positive effect of the magnetization parameter in the case of negatively skewed roughness in the presence of negative variance. Thus, this study provides ample scopes for improving the performance of the bearing system considerably by choosing a suitable combination of magnetization parameter, semi-vertical angle and the conductivities of the plates. © 2010 Springer Science+Business Media B.V.


Patel R.M.,Gujarat Arts and Science College | Deheri G.,Sardar Patel University | Patel H.C.,Sardar Patel University
Acta Polytechnica Hungarica | Year: 2011

An endeavor has been made to investigate the performance of a magnetic fluid based squeeze film between rough circular plates while the upper plate has a porous facing of variable porous matrix thickness. The bearing surfaces are transversely rough. The random roughness of the bearing surfaces is characterized by a random variable with non-zero mean, variance and skewness. The associated Reynolds' equation is stochastically averaged with respect to the random roughness parameter and is solved with appropriate boundary conditions. The results for bearing performance characteristics such as pressure, load carrying capacity and response time for different values of mean, standard deviation and measure of symmetry are numerically computed and presented graphically. First of all it is observed that these performance characteristics increase with the increasing magnetization parameter thereby, suggesting that the performance of the bearing with magnetic fluid lubricant is better than that with the conventional lubricant. It is noticed that the bearing suffers owing to transverse surface roughness. However, the negatively skewed roughness tends to increase the load carrying capacity. Moreover, there is a very significant observation that with a proper selection of the thickness ratio parameter a magnetic fluid based squeeze film bearing with variable porous matrix thickness in the case of negatively skewed roughness can be made to perform considerably better than that of a conventional porous bearing with an uniform porous matrix thickness working with a conventional lubricant. In addition, this article makes it clear that by choosing properly the thickness ratio parameter and the strength of the magnetic field, the adverse impact induced by roughness on the bearing system can be minimized in the case of negatively skewed roughness especially when negative variance occurs. Thus, this study makes it mandatory to account for roughness while designing the bearing system.


Patel R.M.,Gujarat Arts and Science College | Deheri G.M.,Sardar Patel University | Vadher P.A.,Government Science College
Lecture Notes in Mechanical Engineering | Year: 2014

An attempt has been made to discuss the performance of a magnetic fluid based squeeze film between porous infinitely long transversely rough rect­angular plates. A magnetic fluid is used as a lubricant and the external magnetic field is oblique to the lower plate. The roughness of the bearing surfaces is characterized by a stochastic random variable with non-zero mean, variance and skewness. The associated Reynolds' equation is solved with suitable boundary conditions to obtain the pressure distribution in turn, which is used to get the expression for load carrying capacity resulting in the calculation of response time. The graphical representation tends to suggest that the bearing system registers an enhanced performance as compared to that of a bearing system dealing with a conventional lubricant. In fact, the pressure, load carrying capacity and response time increase with increasing magnetization parameter. It is noticed that the bearing suffers in general due to transverse roughness. However, the present study reveals that the negatively skewed roughness improves the performance of the bearing system. In addition, it is observed that the aspect ratio significantly affects the performance of the bearing system. Besides, the present study indicates that although the combined negative influence of the porosity, standard deviation and the aspect ratio dominates the positive effect of the magnetization parameter, there exists some scopes for improving the performance of the bearing system by choosing a suitable combination of the magnetization parameter and the aspect ratio in the case of negatively skewed roughness because even the load carrying © Springer India 2014.

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