Gujarat Adani Institute of Medical science
Gujarat Adani Institute of Medical science
Khakhkhar T.,Gujarat Adani Institute of Medical science |
Shah R.,Gujarat Medical Education and Research Society GMERS Medical College |
Hemavathi K.G.,Medical Institute and Research Center
Drugs and Therapy Perspectives | Year: 2016
Introduction: Antimicrobial prophylaxis before a surgical procedure can reduce the risk of surgical site infections (SSI). The literature suggests that the greater the lag period between the first dose of antimicrobial administration and surgical incision, the greater the chances of developing an SSI. Hence, appropriate timing of the administration of prophylactic antimicrobials is critical to maximize the benefits of prophylaxis. Objective: To examine the association between the timing of prophylactic antimicrobial administration and SSI rate in a tertiary-care hospital. Methodology: A total of 200 patients undergoing elective surgery from different surgical wards were included. Their detailed history, drug use especially that of antimicrobials, and surgical site were observed daily till discharge from the hospital. Odds ratios were calculated to examine the association between the timing of prophylactic antimicrobial use and the rate of SSIs. Results: In the total population of 200 patients, 63 patients (31.5 %) received their first prophylactic antimicrobial dose within 30 min before incision, with SSIs occurring in 6 of these patients (9.5 %); 133 patients (66.5 %) received a prophylactic antimicrobial >30 min before incision, with SSIs occurring in 29 (21.8 %); and the remaining 4 (2 %) patients did not receive preoperative antimicrobials prior to incision, with SSIs occurring in 3 patients (75 %). The odds ratio of developing an SSI in patients receiving their first dose of preoperative antimicrobial >30 min before incision relative to those receiving their first dose of preoperative antimicrobial within 30 min before incision is 2.65. Conclusion: This study examines the association between the timing of antimicrobial administration before surgery and the development of SSIs. Patients who received the antimicrobial dose too early before the procedure, including cases where the surgical procedure was delayed after the antimicrobial was administered, had an increased likelihood of an SSI. Efforts to improve the timing of antimicrobial administration are needed to decrease the SSI rate. © 2016, Springer International Publishing Switzerland.
Parchwani D.N.,GMERS Medical College |
Patel D.D.,Gujarat Adani Institute of Medical science |
Rawtani J.,SN Medical College |
Yadav D.,SMS Medical College
Indian Journal of Clinical Biochemistry | Year: 2017
The A/C transversion at 1166 of the angiotensin II Type 1 Receptor (AT1R) gene per se does not characterize any functional diversity but has been associated with expression of the AT1R, consequently molecular variants of the gene may modulate the possible risk of essential hypertension. The present study was performed to determine the genotypic frequency of the A1166C polymorphism of the AT1R gene in essential hypertensive patients with the aim to assess the effect of variants of this polymorphism in hypertension. AT1R gene amplification was performed by PCR and A1166C polymorphism was determined by enzyme digestion methodologies in 224 consecutively enrolled essential hypertensive patients and 257 controls. Suitable descriptive statistics was used for different variables. Results revealed that genotype and allele distribution of the A1166C variant differed significantly in hypertensives and normotensives. Allele frequency at the A1166C position was 61%A and 39%C for control and 52%A and 48%C for patients. Observed frequencies were compatible with HWE expected frequencies in cases as well as in controls. rs5186 was found to be associated with hypertension (95% CI 1.1453–2.7932, p: 0.0106). The difference remained statistically significant after the multivariate adjustment (p < 0.05), with C/C variant conferring a risk of 1.74-fold of essential hypertension. This association was confirmed by inter-genotypic variations in the mean systolic and diastolic blood pressure in patients. In conclusion, genetic variation at the AT1R gene influences the risk of hypertension stratification and might serve as a predictive marker for the susceptibility to hypertension among affected families. © 2017 Association of Clinical Biochemists of India
Pandya H.B.,Medical Institute and Research Center |
Agravat H.H.,Gujarat Adani Institute of Medical science |
Patel J.S.,Gujarat University
Journal of Clinical and Diagnostic Research | Year: 2017
Introduction: Virulent markers of H. pylori, the vacuolating cytotoxin (vacA), cytotoxin-associated gene product (cagA), induced by contact with epithelium factor antigen (iceA gene) and the urease C gene (ureC) may plays a major role in determining the clinical outcome of Helicobacter infections. Aim: To detect the prevalence of the cagA, vacA, ureC and iceA genotypes of H. pylori from antral biopsy specimens of patients and to associate its role in specific disease. Materials and Methods: The study was conducted at Department of Microbiology of Shree PM Patel College of Paramedical Sciences, Anand, Gujarat, India. Seventy one antral biopsies of symptomatic patients referred for endoscopy from October 2012 to September 2013 were subjected to Multiplex PCR. DNA isolation from 71 biopsy samples was done by using “QIAamp DNA mini kit” from QIAGEN (GmbH, Hilden, Germany). Data was analysed using Chi square (χ2) test and p-value<0.05 is considered significant. Results: Out of the 71 biopsies screened, 22(31%) samples were positive for H. pylori by PCR, with high proportion of cagA positive (17/22 specimen; 77.27%), followed by ureC positive (4/22 specimen; 18.18%) and vacA positive (1/22 specimen; 4.54%) strains. Significant association was found between cagA and female gender (p-value-0.042). Out of 17 cagA positive strains, nine were causing gastritis (52.94%), five were causing reflux oesophagitis (29.41%) and three were causing duodenal ulcer (17.64%). We found 0% prevalence of iceA gene; conversely we had three peptic ulcer patients with only cagA positivity. Conclusion: The cagA positive strain mainly affects the patients with gastritis specifically of female gender and iceA genotype is not a useful marker associated with peptic ulcer disease. Patients should be screened for cagA genotype when reported to be a case of gastritis for early treatment to prevent further complications such as cancer. © 2017, Journal of Clinical and Diagnostic Research. All rights reserved.
Bharadva N.,Gujarat Adani Institute of Medical science
Indian Journal of Forensic Medicine and Toxicology | Year: 2016
Crimes are increasing day by day and criminals intend to destroy the identity of an individual. So stature estimation from skeletal remains bears utmost significance in establishment of individuality of an individual which has been achieved from measurement of long bones. An attempt was made to formulate linear regression equations for estimation of stature in natives of Gujarat for which 148 young and healthy medical students (67 males and 81 females) in age group of 17 to 21 years were examined and measurements were taken, tabulated and statistically analyzed. It can be concluded that there exist a positive correlation between stature & percutaneous length of ulna and linear regression equations so derived can be used for estimation of stature of an individual which will be a useful tool for experts of the anthropology & forensic medicine field. © 2016, Indian Journal of Forensic Medicine and Toxicology. All rights reserved.
PubMed | Pacific Dental College and Hospital, Pacific Medical College and Hospital, Drdy Patil Dental College And Hospital, Modern Dental College and Research Center and 2 more.
Type: | Journal: Military Medical Research | Year: 2016
There is overwhelming evidence that periodontal disease and dental caries affect the majority of populations and that western culture and lifestyle may have a profound influence on oral health, especially in adults. The present study was performed to determine the effect of westernization on the oral health of college students of Udaipur City, Rajasthan.A descriptive cross-sectional study was conducted among students attending various professional and non-professional bachelors degree colleges of Udaipur City, Rajasthan, India, from March 2013 to May 2013. Eight hundred students were selected based on a two-stage random sampling procedure. Westernization was assessed by a self-administered structured questionnaire. Periodontal status, dental caries status and malocclusion were assessed according to World Health Organization (WHO) criteria (1997). Statistical analysis was performed using chi-square and Multivariate logistic regression. The confidence level and level of significance were set at 95 and 5%, respectively.The present study suggested that adverse habits, listening to English music and preferring English food had a significant association with dental caries and periodontal diseases. Malocclusion also showed a significant relationship with consuming English food for snacks and desserts. Multivariate analysis revealed a significantly greater odds ratio (Based on the results of the present study, there is an association between westernization and oral health.
Upadhyah A.,Subharti Medical College |
Misra R.,Subharti Medical College |
Parchwani D.,Gujarat Adani Institute of Medical science |
Maheria P.,GMERS Medical College
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2014
Background: Eating disorders (ED) are one of the most common psychiatric problems faced by adolescents, and are characterized by a persistent course, comorbid psychopathology, medical complications, and elevated mortality. Aims & Objective: To assess the prevalence and correlates of eating disorders in a sample of adolescent Indian females. Materials and Methods: In a cross-sectional survey, 120 adolescents females (age: 13-17 years) filled out questionnaires on eating attitudes and behaviors at one independent school. ED was measured with the 26-item Eating Attitudes Test (EAT). Participants who scored ≥ 20 on the EAT were considered to have disordered eating and effect of psychological, behavioral, and socio-environmental variables in individuals with and without eating disorders, were assessed. Results: Disturbed eating attitudes and behaviors were present in 26.67 % of adolescents girls in the sample studied. This group was significantly older, had earlier menarche and lower BMI. Mean scores and percentage scores on all the scales to assess psychological risk factors were found to be significantly higher in the ED group i.e. there were significant associations (p< 0.0001) between elevated EAT scores and dieting behavior, higher drive for thinness and body dissatisfaction, external pressures, mood susceptibility of feeding patterns, perfectionism, occurrence of negative life events and presence and adequacy of emotional support system. Conclusion: Eating disorders and subthreshold eating conditions are prevalent in a sample of adolescent girls and were strongly associated with various psychological, behavioral, and socio-environmental domains. Future prospective and experimental studies are warranted to advance our understanding of the risk factors to enable better preventive programme planning.
Patel R.,Gujarat Adani Institute of Medical science
Medico-Legal Update | Year: 2016
Forensic autopsies provide medical knowledge as well as it is an important investigating tool that helps in administration of justice. This cross sectional observational study was conducted to know the knowledge and attitude of medical under graduate students for forensic autopsies. A pretested questionnaire covering various aspects of forensic autopsies was given to the medical undergraduate students of 2nd and 3rd year (part I and II). Being a voluntary participation, total 374 students responded to the questionnaire and the answers were analyzed. It can be concluded that more than 92% of students are well aware of indications and procedure of forensic autopsies. 90.9% opined that forensic autopsies are helpful/required in medical education where 78.1% of students wished to witness more number of forensic autopsies though 97.9% of students denied for post mortem on themselves/relatives. At some stage students were found more emotional than practical as mixed review were received on handing over the body to relative where cause of death is known in MLC cases and mixed reviews for performing post mortems on request of relatives without informing police. So still there exists a need to work on legal views of students. © 2016, World Informations Syndicate. All rights reserved.
Bansal M.,Gujarat Adani Institute of Medical science
Indian Journal of Otolaryngology and Head and Neck Surgery | Year: 2016
Though granular myringitis (GM) is not a very rare disease it does not have any classification. Its exact etiology is not known. The granulations on tympanic membrane also occur in association with other lesions of external auditory canal (EAC) and middle ear. The aims of this study were to know the etiological factors of GM and classify the disease according to its etiological factors and associated disorders of EAC and middle ear. Data were retrieved from the search of four electronic databases: PubMed, EMBASE, Cochrane Library, and Google scholar. Relevant articles were also sought by a hand search review of reference books. The databases were searched using the key words otitis externa, external otitis, granular myringitis, granular otitis externa and myringitis. Data were extracted using a pre-defined data-extraction form. The following data were recorded (1) etiological and predisposing conditions; (2) pathological features; (3) associated disorders of external and middle ear. The study proposes the etiological classification of GM. It suggests two major groups: primary and secondary. The primary GM is basically idiopathic and these patients do no have evidences of any other types of otitis media and otitis externa. In the secondary GM the cause is obvious and the patients usually have associated otitis media and/or lesions of external ear canal. Author speculates that habit of self ear cleaning/scratching is a specific etiological factor in cases of primary GM but more studies are required to confirm this theory. © 2016 Association of Otolaryngologists of India
Yerpude P.N.,Gujarat Adani Institute of Medical science |
Jogdand K.S.,Gujarat Adani Institute of Medical science
Indian Journal of Public Health Research and Development | Year: 2016
Introduction: In recent years, in medicine and education field, a paradigm shift has been noticed from experience-based to evidence-based practice. Evidence-based medical practice is based on research, which translates new knowledge into powerful tools for prevention and treatment of disease. Increase in clinical and biomedical research is essential for continuing advances in health care and develop new initiatives. To ensure that the best possible care is provided to patients, research evidence is very important. Students and practitioners should update them regarding recent knowledge. To help foster scientific thoughts and nurture evidence-based practice in clinical settings, research experience is very important. Materials and method: All the medical students of Final Year M.B.B.S. were selected for the study. Out of 290 students,281 give their consent for study. So the total number of study subjects were 281.Ehical clearance was taken from the College Ethical Committee before study. The questionnaire given to student consisted of three sections. The first open section sought information regarding students age, gender, and residence. Section two comprised of close-ended questions focusing on students knowledge and atitude towards research. The last section was also close-ended and aimed to identify barriers towards research as perceived by the students. Results: Most of the students were in the age group of 24-26 yrs (61.57%). Most of the students were female (59.43%).Medical research journal reading habit was found in 39.86% students. Students reading medical journals frequency was poor. Interestingly, majority (45.91%) felt the need for reading journals as part of curriculum only. 37.01% students reading journals out of interest. Overall information regarding Medline indexed medical research journals was very poor.. Only 13.17% students were currently part of any ongoing research project and only 4.6% had any manuscript published or anticipated under name at the time of conduct of the study. 69.40% students desired research as part of basic medical education. Students give lack of research training (20.28%) as principal barrier towards medical research. Conclusion: The present study shows that medical students have positive attitudes towards research despite poor knowledge and awareness of research methods and scientific communication. Thus, there is an urgent need to emphasize the importance of research and to undertake professional programs preparing students as well as supervisors for this task Evolving medical science necessitates research training to be considered as an essential and fundamental component, ‘an underlying principle’, in an innovative undergraduate medical curriculum. It is important to teach undergraduate students the full scientific publishing process, including the peer review process, the format for scientific articles and the necessary skills in word processing. © 2016, Indian Journal of Public Health Research and Development. All rights reserved.
PubMed | P.A. College and Gujarat Adani Institute of Medical Science
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016
In October 2007, The National Cancer Institute (NCI), Thyroid Fine Needle Aspiration State of the Science Conference was held in Bethesda, Maryland hosted by the NCI with the intention of formulating internationally acceptable guidelines for reporting of thyroid cytopathology. This was because, thyroid FNAC have a reporting confusion due to multiplicity of category terminologies. To overcome this, The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was introduced for unifying the terminology and morphologic criteria along with the corresponding risk of malignancy. The Bethesda system for reporting thyroid cytopathology represents a major step towards standardization, reproducibility, improved clinical significance, and greater predictive value of thyroid fine needle aspirates (FNAs).The aim of this study was to elucidate the diagnostic utility of the Bethesda system in reporting thyroid FNAs and to assess the effectiveness of FNAC in the evaluation of thyroid nodules by comparing the results with histopathological evaluation.The present study was carried out in our institute during the July 2012 to September 2014. In this study, 100 FNACs done which were classified according to the Bethesda system and out of them, 60 histopathological evaluations obtained from this group were evaluated. The sensitivity, specificity, positive and negative predictive values were evaluated.Out of 100 FNACs, 06% were Non-diagnostic, 78% were Benign, 04% were Atypical follicular lesion of undetermined significance (AFLUS), 04% were suspicious for Follicular neoplasm (SFN), 01% were suspicious for Follicular neoplasm Hurthle cell type, 03% were suspicious for malignancy (SM), and 04% malignant. In 60 cases, data of follow-up histopathologic examination (HPE) were available. The sensitivity was 88.89% and specificity was 84.31%. The positive and negative predictive value were 50% and 97.7%, respectively.The Bethesda system is very useful for a standardized system of reporting thyroid cytopathology, improving communication between cytopathologists and clinicians, and inter-laboratory agreement, leading to more consistent management approaches. An additional point which is in favor of the implementation of this system is that the classification is directly related to the risk of malignancy in each category, which in turn, prompts the recommended clinical management of that category, thus truly embodying the clinico-pathological correlation in its true spirit. The correlation of FNAC with histopathology is necessary before starting treatment.