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Xiong Y.,Guizhou Provincial Peoples Hospital
Zhonghua yi xue za zhi

OBJECTIVE: To explore the surgical efficacy of lesions in mesencephalic aqueduct and around it with neuroendoscope.METHODS: A total of 14 cases with lesion underwent neuroendoscope. Endoscopic third ventriculostomy (ETV), excision or biopsy and mesencephalic aqueduct plasty were performed.RESULTS: There were primary obstruction (n = 4), glioma (n = 4), intraventricular cysticercosis (n = 2), pineal cell tumor (n = 1), lymphoma (n = 1), brain abscess (n = 1) and germinoma (n = 1). Postoperative cranial computed tomography (CT) and/or magnetic resonance imaging (MRI) showed narrowed ventricle. The outcomes were symptomatic improvement (n = 5), no change (n = 5), worsening (n = 4) and mortality (n = 0).CONCLUSION: ETV, lesion biopsy or partial lesion resection and aqueductal plasty are efficacious for the patients with lesions in mesencephalic aqueduct and around it. Source

Ding J.,Guizhou Provincial Peoples Hospital
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

To evaluate the necessity of splenectomy in radical resection of gastric cancer. Twelve studies comparing outcomes after radical resection of gastric cancer with or without splenectomy were identified. Both fixed effect model and random effect model were used. There were 2628 patients in total. There were significant differences in complications between splenectomy group and spleen-preserving group(OR=1.91, 95% CI:1.28-2.87, P<0.05), while no significant difference in 5-year survival rate was noticed(HR=0.90, 95% CI:0.73-1.11, P>0.05). Radical resection of gastric cancer combined with splenectomy is not associated with improved survival but increased postoperative complications. Source

Lv Y.-S.,Fujian Medical University | Zhou H.-L.,Fujian Medical University | Mao H.-P.,Fujian Medical University | Gao R.,Fujian Medical University | And 2 more authors.
International Urogynecology Journal and Pelvic Floor Dysfunction

Introduction and hypothesis: Intravesical instillation of hyaluronic acid (HA) may restore the integrity of glycosaminoglycan layer in patients with painful bladder syndrome/interstitial cystitis (PBS/IC), and the benefit may be improved with addition of alkalinized lidocaine (AL). Methods: 48 women with severe PBS/IC who failed oral medications were enrolled and divided into one trial and two control groups. The trial group received intravesical 40 mg HA, 10 ml of 2 % lidocaine and 5 ml of 8.4 % sodium bicarbonate on a weekly basis for 8 weeks and then monthly for 4 months with a subsequent follow-up of 24 weeks, while the two control groups received 40 mg HA and mixture of 10 ml of 2 % lidocaine and 5 ml of 8.4%sodium bicarbonate respectively following the same procedure. Response to therapy was evaluated by Global Response Assessment, voids per day, Visual Analogue Scale for pain, frequency and urgency, O'leary-Sant Interstitial Cystitis Symptom Index and Problem Index, cystoscopy and bladder capacity. Results: Overall 45 patients finished this study protocol. The HA + AL group and the AL group showed significant improvement at week 2 (P < 0.01), while the HA group began to show effect at week 4 (P < 0.01). There was no improvement in the AL group at week 24 and these patients quitted the study without follow up. Contrarily, the HA + AL and HA group kept on improving till the end of the study without significant difference between the two groups. Conclusions: Intravesical instillation of HA and AL may provide both immediate and sustained relief of symptoms in severe PBS/IC in this preliminary study. © 2012 The International Urogynecological Association. Source

Du F.-W.,Guizhou Provincial Peoples Hospital
Journal of Interventional Radiology (China)

Objective: To analyze the risk factors and prognosis of patients with coronary stent thrombosis (ST) after receiving percutaneous coronary drug - eluting stent implantation. Methods: Clinical data of 39 patients with ST, who were encountered at author's hospital during the period from July 2006 to March 2012, were retrospectively analyzed. With 1:2 pairing selection, 78 patients with no stent restenosis on coronary angiography encountered during the same period were collected and used as the control group. The risk factors of postoperative stent thrombosis were analyzed. Results: Acute myocardial infarction (AMI) as the initial onset, the smaller stent diameter (≤2.94 mm), the longer length (>29.5 mm) and the lower (>50%) preoperative left ventricular ejection fraction (EF) were related to the occurrence of stent thrombosis. Emergency coronary intervention was carried out once more in 33 patients, of whom one patient died during hospitalization period and the remaining 32 patients recovered at the time of discharge. Conclusion AMI as initial onset, smaller stent diameter, longer stent length and lower preoperative EF (>50%) are independent predictors of coronary stent thrombosis. Stent length ≥29.5 mm and stent diameter ≤2.94 mm are associated with higher occurrence of coronary stent thrombosis. Clinically, most patients with coronary stent thrombosis after receiving percutaneous coronary drug-eluting stent implantation are manifested as AMI. The mortality is higher when stent thrombosis occurs. For such patients emergency coronary intervention is safe and effective. Source

Zha Y.,Guizhou Provincial Peoples Hospital
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

To investigate the effect of continuous renal replacement therapy (CRRT) on the outcome of severe pneumonia in patients receiving long-term immunosuppressants. Thirty-four patients, who had been treated with long-term immunosuppressants, were admitted for severe pneumonia. After admission, the dose of immunosuppressants including glucocorticoids was decreased, and the patients were divided into 2 groups: antibiotic treatment group (n = 16) and antibiotic + CRRT treatment group (n = 18). Before and after treatment, the changes of the patients' condition, chest CT and blood gas analysis were monitored. Biomarkers including C-reactive protein (CRP), interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8(IL-8), white blood cell and neutrophil counts were determined. After treatment, the levels of CRP[(109 ± 24) vs (40 ± 13) mg/L], IFN-γ [(151 ± 28) vs (42 ± 12) ng/L], TNF-α [(301 ± 45) vs (118 ± 28) pg/L], IL-6 [(214 ± 45) vs (76 ± 23) pg/L], IL-8[(590 ± 121) vs (159 ± 60) pg/L], white blood cell count [(14.3 ± 5.7)×109/L vs (8.5 ± 2.7)×109/L], and neutrophil percentage [(91.3 ± 3.1)% vs (75.3 ± 2.6)%] decreased significantly in the antibiotic + CRRT group (P < 0.05) as compared to the antibiotic treatment group. In the antibiotic + CRRT group, blood gas showed significant improvement in pH [(7.30 ± 0.12) to (7.37 ± 0.18)], SaO2 [(80.6 ± 7.6)% to (91.9 ± 7.3)%] and PaO2 (41 ± 6) mm Hg (1 mm Hg = 0.133 kPa) to (71 ± 9) mm Hg. The patients' condition and chest CT abnormalities also improved more rapidly in the antibiotic + CRRT group. The 6-month survival was increased by 12.9% in the antibiotic + CRRT group as compared to the antibiotic group (P < 0.05). CRRT is effective in clearance of inflammatory mediators and may increase survival of severe pneumonia patients receiving long-term treatment of immunosuppressants. Source

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