Wang W.,Guiyang Medicid College |
Yang H.,Guiyang Medicid College |
Liu F.,Guiyang Medicid College |
Xiang X.,Guiyang Medicid College |
Zhang W.,Guiyang Medicid College
Cancer Research and Clinic | Year: 2015
Objective: To explore expression of plexinAl and Ki-67 in tissue of human brain glioma cells and their clinical significance. Methods 43 specimens from patients with brain glioma were collected. Immunohistochemical (IHC) staining was used for detecting the expression of tissue plexinA1 and Ki-67 in human glioma cells of 43 cases of patients with brain glioma. The positive expression rate of plexinAl and Ki-67 among the different pathological grade tissues and their clinical significance were analyzed. So did correlation studies about plexinAl and Ki-67. Results: The positive expression rates of plexinAl in I-II grade group (18 cases) and III-IV grade group (25 cases) were 22.22 % (4/18) and 72.00 % (18/25) (P < 0.05). The positive expression rates of Ki-67 in I-II grade group and III-IV grade group were 16.67 % (3/18) and 56.00 % (14/25), respectively (P < 0.05). PlxinA1 and Ki-67 expression in the tissue of human brain glioma were positively correlated (r = 0.997, P < 0.05). Conclusions The positive expression rate of plexinA1 is higher in high malignancy human glioma group than that in low malignancy group which has an important reference value in the estimation of prognosis for human glioma. PlexinA1 and Ki-67 maybe synergism in occurrence and development of glioma.