Guiyang Centers for Diseases Control and Prevention

Guiyang, China

Guiyang Centers for Diseases Control and Prevention

Guiyang, China
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Zeng Q.-B.,Guiyang Medical University | Xu Y.-Y.,Guiyang Medical University | Yu X.,Guiyang Centers for Diseases Control and Prevention | Yang J.,Guiyang Centers for Diseases Control and Prevention | And 2 more authors.
Environmental Toxicology and Pharmacology | Year: 2014

Chronic exposure to combined fluoride and arsenic continues to be a major public health problem worldwide, affecting thousands of people. In recent years, more and more researchers began to focus on the interaction between the fluorine and the arsenic. In this study, the selected investigation site was located in China. The study group was selected from people living in fluoride-arsenic polluted areas due to burning coal. The total number of participants was 196; including the fluoride-arsenic anomaly group (130) and the fluoride-arsenic normal group (63). By observing the changes in gene and protein expression of PTH/PKA/AP1 signaling pathway, the results show that fluoride can increase the expression levels of PTH, PKA, and AP1, but arsenic can only affect the expression of AP1; fluoride and arsenic have an interaction on the expression of AP1. Further study found that fluoride and arsenic can affect the mRNA expression level of c-fos gene (AP1 family members), and have an interaction on the expression of c-fos, but not c-jun. The results indicate that PTH/PKA/AP1 signaling pathway may play an important role in bone toxicity of fluoride. Arsenic can affect the expression of c-fos, thereby affecting the expression of transcription factor AP1, indirectly involved in fluoride-induced bone toxicity. © 2013 .


Zeng Q.-B.,Guiyang Medical University | Xu Y.-Y.,Guiyang Medical University | Yu X.,Guiyang Centers for Diseases Control and Prevention | Yang J.,Guiyang Centers for Diseases Control and Prevention | And 2 more authors.
Toxicology Research | Year: 2014

Chronic exposure to combined fluoride and arsenic continues to be a major public health problem worldwide, affecting thousands of people. Although there have been reports in the literature about the toxicity of arsenic and fluoride individually, there is very little known about the combined effects of these two elements. The participates were selected from people living in fluoride-arsenic polluted areas due to burning coal. By observing the changes of renal function biomarkers, the results show that fluoride and arsenic can induce glomerular and tubular injury. For the observed exposure levels, the combined effect of fluoride and arsenic on renal function is mainly one of antagonism. Moreover, the benchmark dose and its lower confidence limit were calculated to estimate the exposure limits for urine arsenic (UAs) and urine fluoride (UF). The results indicate that the critical concentrations of UF and UAs for renal function injury were estimated, respectively, to be 0.54 mg g-1 Cr and 10.50 μg g-1 Cr in a population co-exposed to fluoride and arsenic; and urine albumin can be used as a relatively sensitive biomarker of renal function. © 2014 the Partner Organisations.


PubMed | Guiyang Centers for Diseases Control and Prevention and Guiyang Medical University
Type: Journal Article | Journal: Environmental toxicology and pharmacology | Year: 2014

Chronic exposure to combined fluoride and arsenic continues to be a major public health problem worldwide, affecting thousands of people. In recent years, more and more researchers began to focus on the interaction between the fluorine and the arsenic. In this study, the selected investigation site was located in China. The study group was selected from people living in fluoride-arsenic polluted areas due to burning coal. The total number of participants was 196; including the fluoride-arsenic anomaly group (130) and the fluoride-arsenic normal group (63). By observing the changes in gene and protein expression of PTH/PKA/AP1 signaling pathway, the results show that fluoride can increase the expression levels of PTH, PKA, and AP1, but arsenic can only affect the expression of AP1; fluoride and arsenic have an interaction on the expression of AP1. Further study found that fluoride and arsenic can affect the mRNA expression level of c-fos gene (AP1 family members), and have an interaction on the expression of c-fos, but not c-jun. The results indicate that PTH/PKA/AP1 signaling pathway may play an important role in bone toxicity of fluoride. Arsenic can affect the expression of c-fos, thereby affecting the expression of transcription factor AP1, indirectly involved in fluoride-induced bone toxicity.

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