Guangzhou University of Chinese Medicine

www.gzhtcm.edu.cn
Guangzhou, China

Guangzhou University of Chinese Medicine is an institution of higher learning, located in Guangzhou, the capital of Guangdong Province, China. It was founded in 1956, and is one of four earliest established institutions in China specializing in Chinese traditional medicine. It was originally directly affiliated to Ministry of Health of the People's Republic of China and the State Administration of Traditional Medicine. In 2000, the university became a joint venture between the central government and provincial government, but mainly under the jurisdiction of Guangdong Province. Wikipedia.

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Luo Y.,Guangzhou University of Chinese Medicine | Wang Q.,Guangzhou University of Chinese Medicine | Zhang Y.,Guangzhou University of Chinese Medicine
Journal of Ethnopharmacology | Year: 2016

Ethnopharmacological relevance Neurodegenerative diseases (NDs) is a time-dependent course for a sequence of conditions that primarily impact the neurons in the human brain, ultimately, resulting in persistence and progressive degeneration and / or death of nerve cells and reduction of cognition and memory function. Currently, there are no therapeutic approaches to cure neurodegeneration, except certain medicines that temporarily alleviate symptoms, facilitating the improvement of a patients' quality of life. Danggui-shaoyao-san (DSS), as a famous Chinese herbal formula, has been widely used in the treatment of various illnesses, including neurodegenerative diseases. Although well-practiced in clinical medicine, the mechanisms involved in DSS for the treatment of neurodegenerative diseases remain elusive. Materials and methods In the present study, a novel systems pharmacology approach was developed to decipher the potential mechanism between DSS and neurodegenerative disorders, implicated in oral bioavailability screening, drug-likeness assessment, target identification and network analysis. Results Based on a comprehensive systems approach, active compounds of DSS, relevant potential targets and targets associated with diseases were predicted. Active compounds, targets and diseases were used to construct biological networks, such as, compound-target interactions and target-disease networks, to decipher the mechanisms of DSS to address NDs. Conclusions Overall, a well-understood picture of DSS, hallmarked by multiple herbs-compounds-targets-pathway-cooperation networks for the treatment of NDs, was revealed. Notably, this systems pharmacology approach provided a novel in silico approach for the development paradigm of traditional Chinese medicine (TCM) and the generation of new strategies for the management of NDs. © 2015 Elsevier Ireland Ltd.


Li X.,Guangzhou University of Chinese Medicine
Journal of Agricultural and Food Chemistry | Year: 2017

Current in vitro antioxidant assays have several limitations, which frequently cause inconsistent results. The study develops a new antioxidant assay using the 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide radical (PTIO•). After the investigation of various factors, the experimental protocol was briefly recommended as follows: PTIO• and the sample solution were added to phosphate buffer (pH 7.4, 50 mM), incubated at 37 °C for 2 h, and then spectrophotometrically measured at 557 nm. The validation test based on 20 pure compounds and 30 lyophilized aqueous extracts suggested that PTIO• scavenging had a good linear relationship, stability, and reproducibility. In the ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry analysis, PTIO• was observed to give m/z 234 when encountering l-ascorbic acid. As an antioxidant assay, PTIO• scavenging possesses four advantages, i.e., oxygen-centered radical, physiological aqueous solution, simple and direct measurement, and less interference from the tested sample. It can also satisfactorily analyze the antioxidant structure-activity relationship. PTIO• scavenging has no stereospecificity and is at least involved in H+ transfer. © 2017 American Chemical Society.


Li X.,Guangzhou University of Chinese Medicine
Food Chemistry | Year: 2013

The deoxyribose degradation assay is widely used to evaluate the hydroxyl (.OH) radical-scavenging ability of food or medicines. We compared the hydroxyl radical-scavenging activity of 25 antioxidant samples prepared in ethanol solution with samples prepared after removing the ethanol (residue). The data suggested that there was an approximately 9-fold difference between assay results for the ethanol solution and residue samples. This indicated a strong alcoholic interference. To further study the mechanism, the scavenging activities of 18 organic solvents (including ethanol) were measured by the deoxyribose assay. Most pure organic solvents (especially alcohols) could effectively scavenge hydroxyl radicals. As hydroxyl radicals have extremely high reactivities, they will quickly react with surrounding solvent molecules. This shows that any organic solvent should be completely evaporated before measurement. The proposed method is regarded as a reliable hydroxyl radical-scavenging assay, suitable for all types of antioxidants. © 2013 Elsevier Ltd. All rights reserved.


Zhou X.L.,Guangzhou University of Chinese Medicine
Journal of endourology / Endourological Society | Year: 2013

Open radical inguinal lymphadenectomy is reported to have morbidity as high as 50%. We describe our endoscopic inguinal lymphadenectomy that aims at decreasing the morbidity of the procedure without compromising the oncologic outcomes. Eleven groin dissections were undertaken in seven male patients. The procedure was performed via three ports. The first one was a 10-mm incision 3 mm distal to the apex of the femoral triangle. Two additional trocars (10 mm and 5 mm) were positioned 6 cm medially and laterally to the apex of the triangle, respectively. Taking the great saphenous vein as a landmark, the superficial and deep components were dissected. The boundaries of dissection were the same as those of radical inguinal lymphadenectomy. The numbers of lymph nodes harvested were recorded. The morbidity was retrospectively analyzed. The mean operative time was 126 minutes. The mean number of lymph nodes was 12.3. The averaged output of drainage per leg was 50.8 mL each day. There were only three minor complications: One patient had hypercarbia and pneumoderm, and another had 50 mL of seroma; the third had 180 mL of lymphocele. Follow-up ranged from 4 to 27 months (mean 16.3); there was no evidence of recurrence and other sequelae. Endoscopic inguinal lymphadenectomy is feasible for patients with penile cancer and genital malignancy. The technique reduces the risk of complication rate, and the oncologic outcome is highly promising. Larger studies, longer term follow-up are needed to assess the oncologic control and possible morbidity.


Li X.,Guangzhou University of Chinese Medicine
Journal of Agricultural and Food Chemistry | Year: 2012

The original pyrogallol (1,2,3-trihydroxybenzene) method, which was developed specifically for superoxide dismutase, is now widely used for measuring superoxide-scavenging of other antioxidants. However, the strong pH effect has been ignored. In this study, the influencing factors have been systematically investigated for the first time, and a number of experiments have proved that the pH is of major importance. As major antioxidants contain carboxylic acid, ester, or lactone groups, pH 8.2 should be modified to physiological pH 7.4. The improved procedure is as follows. A pyrogallol solution (in 1 M HCl) is thoroughly mixed with pH 7.4 Tris-HCl buffer; A 325 nm is measured every 30 s for 5 min at 37 °C. As the ΔA325 nm, control value reflects the initial concentration of substrate •O2 -, it should be well controlled to guarantee the accuracy of the method. The improved pyrogallol method is a reliable and cheap superoxide-scavenging assay suitable for all types of antioxidants. © 2012 American Chemical Society.


Wei W.,Guangzhou University of Chinese Medicine | Wei B.,Linyi Peoples Hospital
Journal of Arthroplasty | Year: 2014

The objective of this study was to determine whether topical tranexamic acid (TXA) carried similar hemostatic effect compared with intravenous TXA in total hip arthroplasty (THA). Three hundred and three THA patients were enrolled and randomized into 3 groups: no TXA group, topical and intravenous TXA group. The results showed that the topical and intravenous TXA group had reduced but similar blood transfusion rates (5.88% v. s. 5.94%, P = 0.816). No significant difference was detected in total blood loss between the two TXA groups [(963.4 ± 421.3) ml vs. (958.5 ± 422) ml P = 0.733]. We conclude that topical use of TXA was equally effective and safe compared with intravenous TXA in reducing blood loss and transfusion rate following THA without substantial complications. © 2014 Elsevier Inc. All rights reserved.


Fang B.,Guangzhou University of Chinese Medicine
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2013

To investigate the clinical application and early results of combined epiphyseal preservation. Between March 2010 and March 2011, and autograft bone transfer for limb salvage in children with osteosarcoma. 3 children with osteosarcoma were treated with epiphyseal preservation and autograft bone transfer. There were 1 boy and 2 girls with the age of 10-14 years. The disease duration was 2 weeks to 3 months. The tumors were rated as type II according to San-Julian radiological classification and as type IIB according to Enneking surgical classification. The locations were the distal femur in 1 case and the proximal tibia in 2 cases. The surgical technique included preoperative neoadjuvant chemotherapy, excision of part of the epiphysis, preservation of subarticular epi physis, external fixation with Ilizarov apparatus and transport osteogenesis treatment. Safe excision border was confirmed by histological examination. Postoperative observation included the wound healing, local recurrence or distant metastasis, length, speed, alignment, and regeneration of transplanted bone, the length and function of the affected limb. The postoperative histological examination proved the safe surgical margin in all 3 patients. The incision healing by first intention was obtained at distal femur in 1 case and by second intention at proximal tibia in 2 cases at 4 weeks after changes of dressing. Three patients were followed up 12, 18, and 24 months, respectively. There was no local recurrence or distant metastasis during follow-up. Two cases had pin-tract infection at 10 months after external fixation and were cured after changes of dressing and antibiotics administration. The length of transplanted osteogenisis was 18.0, 9.5, and 16.0 cm, respectively. The speed of lengthening was 2.57, 2.07, and 1.20 cm/month, respectively. One patient had alignment deviation during lengthening, which was adjusted under anaesthesia. Bony healing was achieved at 8 months after lengthening end in 2 cases and external fixation was removed; 1 patient had poor bone growth and was given retraction for promoting bone growth. At last follow-up, the length of the affected limbs was 1.0-1.5 cm shorter than that of normal limbs, but no abnormalities was observed at donor sites. The affected knee flexion reached 90 degrees and 120 degrees in 2 patients and poor knee function was observed in 1 patient for external fixation. The combined epiphyseal preservation and transport osteogenesis technique can be used for bone defect repair by lengthening the residual bone. It is a promising limb salvage treatment for children with osteosarcoma.


Patent
Guangzhou University of Chinese Medicine | Date: 2014-07-02

The present invention relates to a use of patchouli alcohol in the preparation of a drug against Helicobacter pylori. The drug according to the present invention is composed of the patchouli alcohol and pharmaceutically acceptable additives, wherein the content of the patchouli alcohol is 0.5-70%. The patchouli alcohol according to the present invention has a quite narrow antimicrobial spectrum, and may selectively inhibit Helicobacter pylori without influencing growth and propagation of other bacterial populations (including other gram negative bacteria). The patchouli alcohol may kill Helicobacter pylori without damaging probiotics, and may keep an ecological balance of bacterial populations in the intestinal tract of human body. Therefore, the patchouli alcohol may be used for treatment of diseases caused by infection of Helicobacter pylori, such as gastritis, peptic ulcer and early gastric cancer.


Patent
New York University and Guangzhou University of Chinese Medicine | Date: 2014-05-06

Provided is a method for inhibiting the growth of tumor cells comprising administering to an individual in need of treatment, a composition comprising a therapeutically effective amount of Lappaol F. Also provided are compositions comprising Lappaol F and a pharmaceutically acceptable carrier.


News Article | February 28, 2017
Site: www.PR.com

A new study confirms these results and patients’ three month follow up appointments continue to be significantly intact. Three months later, the success rate remained remarkably at 89%, demonstrating that acupuncture and moxibustion provides both short term and long term benefits for depressive patients. Depression affects over 15 million adults in the US, roughly 6.7% of our population. This research brings hope to this severe, yet common illness. Dana Point, CA, February 28, 2017 --( Dr. Kathleen Albertson, a licensed acupuncturist, and herbalist remarks, “This study encourages those patients with depression to seek acupuncture therapy in conjunction with their western protocols. It not only opens the door for the patient to improve his/her quality of life, but may lead the way to a decrease in the patients’ need or use of Western pharmaceutical drugs which have severe side effects.” “It is not our place, nor is it legal, for an acupuncturist to recommend that a patient change any use or dosage of medications prescribed by a Western MD; but often the patient and their doctor reach solutions that may benefit that patient.” She further remarks, “Psychologists and therapists have a long history of acknowledgement and support for recommending acupuncture to their patients for not only depression, but stress, postpartum, and anxiety, as well.” Acupuncture releases endorphins and calms the nervous system, allowing the body and mind to reach homeostasis (balance). It is proven to reduce pain and support our physical and emotional systems, and has been utilized for over 5000 years. “It is never too late to research new options that can help you,” she reports. Dr. Albertson also holds a Master’s degree in Counseling, and a PhD in Holistic Nutrition. She has been in practice for 23 years and currently practices in Dana Point, CA. (www.KathieA.us). Dana Point, CA, February 28, 2017 --( PR.com )-- Patients were measured using the Hamilton Depression Scale at the Guangzhou University of Chinese Medicine. Acupuncture plus moxibustion (a therapy used to warm the needles while the patient undergoes treatment) was used 2 times per week for 12 weeks with 163 patients with mild to moderate depression. Acupuncture is used for both acute, situational depression, as well as chronic chemical imbalances.Dr. Kathleen Albertson, a licensed acupuncturist, and herbalist remarks, “This study encourages those patients with depression to seek acupuncture therapy in conjunction with their western protocols. It not only opens the door for the patient to improve his/her quality of life, but may lead the way to a decrease in the patients’ need or use of Western pharmaceutical drugs which have severe side effects.”“It is not our place, nor is it legal, for an acupuncturist to recommend that a patient change any use or dosage of medications prescribed by a Western MD; but often the patient and their doctor reach solutions that may benefit that patient.”She further remarks, “Psychologists and therapists have a long history of acknowledgement and support for recommending acupuncture to their patients for not only depression, but stress, postpartum, and anxiety, as well.”Acupuncture releases endorphins and calms the nervous system, allowing the body and mind to reach homeostasis (balance). It is proven to reduce pain and support our physical and emotional systems, and has been utilized for over 5000 years. “It is never too late to research new options that can help you,” she reports.Dr. Albertson also holds a Master’s degree in Counseling, and a PhD in Holistic Nutrition. She has been in practice for 23 years and currently practices in Dana Point, CA. (www.KathieA.us).

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