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Wang H.-J.,Jinan University | Hou D.-B.,Jinan University | Huan S.-W.,Jinan University | Liu N.,Jinan University | And 5 more authors.
Medicine (United States) | Year: 2015

Incidence of scapular spine (SS) fractures as a result of complications of reverse total shoulder arthroplasty is relatively high leading to inferior clinical outcomes and an increased risk of revision and dislocation. Fractures of SS because of trauma, including the acromion, constitute 6% to 23% of scapula fractures. The purpose of this study was to classify the SS and present specific geometrical parameters according to osteologic features. A total of 319 intact dry scapulae were collected and classified based on morphological characteristics and shape of the SS. Nine bony landmarks were also chosen and described for their relevance to regions of interest for scapular fixation. Five specific types of SS were noted and the most prevalent groups were Type 1 (Fusiform shape) (47.17%) and Type 5 (Horizontal S-shape) (19.18%). Overall, Types 3, 4, and 1 showed thicker landmark values compared to Type 5, with Type 2 having smaller values. Our classification into 5 distinct types allowed appreciation of the anatomical variance of SSs. The contours of Types 5 and 1 presented a more complex morphology and may lead to a worse surgical approach due to a fracture. As Types 2 and 5 were much thinner than the other types, these may be more susceptible to fractures. © 2015 Wolters Kluwer Health, Inc.


Song Y.-Z.,Hebei Medical University | Guan J.,The Third Hospital of Shi Jiazhuang | Wang H.-J.,University of Jinan | Ma W.,Hebei Medical University | And 7 more authors.
Journal of Clinical Laboratory Analysis | Year: 2016

Background: Resistin is an adipocytokine associated with inflammation and insulin resistance. Recent studies have shown that resistin plays an important role in the pathogenesis and progression in osteoarthritis (OA) patients. The current study was aimed at investigating the relationship between resistin in serum and synovial fluid (SF) and disease severity in patients with knee osteoarthritis. Method: Seventy-four patients diagnosed with knee OA and 79 healthy controls receiving regular body check in our hospital were recruited in the study. The Noyes score method was used to assess articular cartilage damage arthroscopically. The symptomatic severity was evaluated according to the Western Ontario McMaster University Osteoarthritis (WOMAC) scores. The radiographic disease severity of OA was assessed by the Kellgren-Lawrence (K–L) grading system. The resistin levels in serum and SF were determined by enzyme-linked immunosorbent assay. Cartilage degradation marker CTX–II in SF was also examined. Results: SF but not serum resistin levels are positively associated with Noyes scores, K-L grading scores WOMAC pain scores, physical functional scores and WOMAC total scores. In addition, SF resistin correlated positively with CTX-II. Conclusion: Resistin in SF might serve as a potential biomarker for reflecting the disease severity and cartilage degenerative extent of knee OA. © 2015 Wiley Periodicals, Inc.


Huang C.,Guangzhou Orthopedic Hospital | Zhang C.,Guangzhou Orthopedic Hospital | Wang H.,Sun Yat Sen University | Liang C.,Guangzhou Orthopedic Hospital | And 3 more authors.
Journal of Hand Surgery | Year: 2015

Purpose In this study, we designed a prospective project to test the hypothesis that acute fourth and fifth carpometacarpal (CMC) fracture dislocations can be treated conservatively with good restoration of strength, range of motion (ROM), and function, whereas patients with delayed treatment of fourth and fifth CMC fracture dislocations should be treated with open reduction and internal fixation (ORIF). Methods We evaluated the results of 20 patients with acute and 6 patients with subacute fourth and fifth CMC fracture dislocations. All 20 acute CMC fracture dislocations were treated conservatively, whereas 3 of the 6 patients with subacute injuries underwent operative intervention. The sensibility, ROM, and grip strength of the hands were tested during 1-year follow-up. The Michigan Hand Outcomes Questionnaire and control radiographs were also taken. Results All 20 patients with acute CMC fracture dislocations showed good restoration of grip strength, ROM, and function, with an average Michigan Hand Outcomes Questionnaire score of 98 ± 2 at 1-year follow-up. Patients with delayed diagnosis who underwent conservative treatment had noticeable deformity of their injured hands, pain complaints, limited ROM at the fourth and fifth CMC joints, and decreased grip strength. The 3 patients with delayed diagnosis treated with ORIF showed good restoration of grip strength, ROM, and function. Conclusions Patients with acute CMC fracture dislocations can be treated by closed reduction with good restoration of grip strength, ROM, and function. In patients with delayed presentation of CMC fracture dislocations, we recommend ORIF. © 2015 American Society for Surgery of the Hand All rights reserved.


PubMed | Guangzhou Orthopedic Hospital and Sun Yat Sen University
Type: Journal Article | Journal: The Journal of hand surgery | Year: 2015

In this study, we designed a prospective project to test the hypothesis that acute fourth and fifth carpometacarpal (CMC) fracture dislocations can be treated conservatively with good restoration of strength, range of motion (ROM), and function, whereas patients with delayed treatment of fourth and fifth CMC fracture dislocations should be treated with open reduction and internal fixation (ORIF).We evaluated the results of 20 patients with acute and 6 patients with subacute fourth and fifth CMC fracture dislocations. All 20 acute CMC fracture dislocations were treated conservatively, whereas 3 of the 6 patients with subacute injuries underwent operative intervention. The sensibility, ROM, and grip strength of the hands were tested during 1-year follow-up. The Michigan Hand Outcomes Questionnaire and control radiographs were also taken.All 20 patients with acute CMC fracture dislocations showed good restoration of grip strength, ROM, and function, with an average Michigan Hand Outcomes Questionnaire score of 98 2 at 1-year follow-up. Patients with delayed diagnosis who underwent conservative treatment had noticeable deformity of their injured hands, pain complaints, limited ROM at the fourth and fifth CMC joints, and decreased grip strength. The 3 patients with delayed diagnosis treated with ORIF showed good restoration of grip strength, ROM, and function.Patients with acute CMC fracture dislocations can be treated by closed reduction with good restoration of grip strength, ROM, and function. In patients with delayed presentation of CMC fracture dislocations, we recommend ORIF.Therapeutic IV.


PubMed | Jinan University, The Third Hospital of Shi Jiazhuang, Guangzhou Orthopedic Hospital and Hebei Medical University
Type: Journal Article | Journal: Journal of clinical laboratory analysis | Year: 2016

Resistin is an adipocytokine associated with inflammation and insulin resistance. Recent studies have shown that resistin plays an important role in the pathogenesis and progression in osteoarthritis (OA) patients. The current study was aimed at investigating the relationship between resistin in serum and synovial fluid (SF) and disease severity in patients with knee osteoarthritis.Seventy-four patients diagnosed with knee OA and 79 healthy controls receiving regular body check in our hospital were recruited in the study. The Noyes score method was used to assess articular cartilage damage arthroscopically. The symptomatic severity was evaluated according to the Western Ontario McMaster University Osteoarthritis (WOMAC) scores. The radiographic disease severity of OA was assessed by the Kellgren-Lawrence (K-L) grading system. The resistin levels in serum and SF were determined by enzyme-linked immunosorbent assay. Cartilage degradation marker CTX-II in SF was also examined.SF but not serum resistin levels are positively associated with Noyes scores, K-L grading scores WOMAC pain scores, physical functional scores and WOMAC total scores. In addition, SF resistin correlated positively with CTX-II.Resistin in SF might serve as a potential biomarker for reflecting the disease severity and cartilage degenerative extent of knee OA.


Chen Z.-J.,Southern Medical University | Huang X.-C.,Southern Medical University | Xiang X.-B.,Guangzhou Orthopedic Hospital | Chen C.,Southern Medical University | Li Y.-K.,Southern Medical University
Chinese Journal of Tissue Engineering Research | Year: 2015

BACKGROUND: It is generally recognized that cervical rotation manipulation can increase the risk of detachment of unstable plaques in carotid atherosclerosis, but few studies are reported on the influence of cervical rotation manipulation on the stable plaque in early carotid atherosclerosis. OBJECTIVE: To explore the influence of the cervical rotation manipulation on the lipid contents in carotid atherosclerotic plaque in a rabbit model of early carotid atherosclerosis. METHODS: After being fed for 15 days with normal diet, 30 male New Zealand White rabbits were further fed for 18 weeks with normal diet (n = 10; control group) or a high-fat diet containing 2% cholesterol, 10% lard and 88% normal granules to build rabbit models of early carotid atherosclerosis with stable carotid plaque (n = 20). At 14 weeks of feeding with high-fat diet, the experimental rabbits fed with high-fat diet were randomly divided into a cervical rotation manipulation group (n = 10) and a model group (n = 10). The rabbits in the cervical rotation manipulation group underwent cervical rotation manipulation to the left and right sides, once each side, with the maximal range of rotation. Total five cervical rotation manipulations, once every 3 days, were performed. RESULETS AND CONCLUSION: The 1 450 cm and 1 660 cm peaks of the Raman spectrum of lipid in the carotid atherosclerotic plaque of rabbit models were not distinctly present in the control group, however, they were obviously observed in the cervical rotation manipulation group and model group. Nevertheless, the relative intensity differences at spectrum characteristic peaks were not significant between cervical rotation manipulation group and model group (P > 0.05). The environmental findings indicate that the lipid content in carotid atherosclerotic plaque of rabbit models of early carotid atherosclerosis cannot be increased after short-term administration of cervical rotation manipulation. © 2015, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.


Chen Z.-J.,Southern Medical University | Yang X.-W.,Guangdong Provincial Corps Hospital of Chinese Peoples Armed Police Force | Xiang X.-B.,Guangzhou Orthopedic Hospital | Chen C.,Southern Medical University | And 2 more authors.
Yiyong Shengwu Lixue/Journal of Medical Biomechanics | Year: 2015

Objective: To investigate the influence from compressing manipulation by flexing hip and knee in supine position on stress distributions in the pelvis and strain distributions in the sacroiliac joints by 3D finite element method, and discuss the possibility of moving the whole sacroiliac joints under such manipulation. Methods: A 3D finite element model of the normal pelvis was constructed based on CT images. According to the manipulation principle, the compressing force in flexing hip and knee was decomposed in two directions, and loaded on the 3D finite element model to calculate stress of the pelvis and strain of the sacroiliac joints. Results: Under the loading of simulative manipulation, stress of the pelvis was mainly located at 1/3 part of the anterior inferior of the sacroiliac joints, the greater sciatic notch, and the middle 1/3 part of the inferior and anterior of gluteal lines. The maximum strain of the sacroiliac joints was mainly located in the posterior superior, posterior inferior and central 1/2 part of the sacroiliac joints. Conclusions: The compressing manipulation by flexing hip and knee can only move 1/3 part of the interior of the sacroiliac joints, rather than the whole of the sacroiliac joints. Copyright © 2015 by the Editorial Board of Journal of Medical Biomechanics.


Wang J.-L.,Guangzhou Orthopedic Hospital | Pi A.-P.,Guangzhou Orthopedic Hospital | Xin Z.-Q.,Guangzhou Orthopedic Hospital | Yu B.-X.,Guangzhou Orthopedic Hospital | And 4 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2014

BACKGROUND: For patients with rheumatoid arthritis and Kümmell’s disease, how to effectively control back pain, to recover patient’s locomotor activity and to avoid a vicious cycle of disuse osteoporosis is a key therapeutic target. Kyphoplasty is a recently developed new technology of minimally invasive spine surgery. Few reports concerned the kyphoplasty for rheumatoid arthritis and Kümmell’s disease. OBJECTIVE: To assess the clinical outcome of bone cement kyphoplasty for the treatment of Kümmell’s disease combined with rheumatoid arthritis. METHODS: From June 2012 to July 2013, 11 female patients at the age of 65.4±5.1 years with Kümmell’s disease combined with rheumatoid arthritis, who suffered from severe back pain, were treated with bone cement vertebroplasty. Back pain and imaging indexes were compared and observed before surgery and during follow-up. Imaging indexes contained preoperative and postoperative anterior height of vertebral body after fractures, the ratio of anterior height to posterior height of the vertebral body, and local kyphosis angle (Cobb method). RESULTS AND CONCLUSION: No patients were lost to follow up. 11 patients were followed up for 6 to 12 months. Significant differences in follow-up and preoperative Visual Analogue Scale scores, anterior height of vertebral body after fractures, the ratio of anterior height to posterior height of the vertebral body, and local kyphosis angle were detected (P < 0.05). Two patients experienced bone cement leakage. No severe complications appeared such as pulmonary embolism or neurological dysfunction. These data confirmed that bone cement vertebroplasty for rheumatoid arthritis combined with Kümmell’s disease can effectively lessen back pain, partially restore the height of vertebral body after fracture, rebuild spinal stabilization, reduce local kyphosis, and is a safe effective repair method. © 2014 Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.


Huo L.W.,Guangzhou Orthopedic Hospital | Ye Y.L.,Guangzhou Orthopedic Hospital | Wang G.W.,Guangzhou Orthopedic Hospital | Ye Y.G.,Guangzhou Orthopedic Hospital
Journal of Investigative Medicine | Year: 2015

Background: Elevated serum and synovial fluid (SF) fractalkine (CX3CL1) levels have been detected in patients with knee osteoarthritis (OA). The current study was carried out to investigate the association between serum and SF fractalkine levels with symptomatic severity in patients with knee OA. Method: One hundred ninety-three patients with OA and 182 healthy controlswere enrolled in this study. The symptomatic severity was assessed by the Western Ontario McMaster University Osteoarthritis scores. Results: Fractalkine levels in SF and serum were both positively associated with self-reported greater pain and physical disability. Conclusions: Fractalkine in SF and serum may serve as a biomarker for reflecting symptomatic severity. Therapeutic interventions that target fractalkine signaling pathways to delay OA-related symptoms deserve further study. © Lippincott Williams & Wilkins.

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