Yu H.,Sun Yat Sen University |
Yu H.,General Hospital of Guangzhou Military Command |
Yuan L.,The First Affiliated Hospital of Kunming Medical College |
Yang Y.,Sun Yat Sen University |
And 5 more authors.
Immunobiology | Year: 2016
Age-related macular degeneration (AMD) is the leading cause of blindness among senior citizens of developed countries, with currently unknown etiology. Despite the close associations between AMD development and inhibitory complement factor H mutations, the first step of complement activation, which is the antibody response in AMD patients, has not been studied. Here, we obtained blood and tear samples from AMD patients and Non-AMD controls. We found that compared to Non-AMD controls, AMD subjects had increased IgA titers in serum and tear, and had elevated levels of circulating antibody-secreting plasmablasts. The increase in antibody titer was limited to the IgA isotype, since no significant differences were observed in IgM and IgG isotypes between AMD patients and Non-AMD controls. Interestingly, this increased antibody response in AMD patients was correlated with disease severity, as late AMD patients had increased IgA titers in serum and tear, as well as elevated plasmablast frequency after staphylococcal enterotoxin B stimulation, compared to early AMD patients. Together, our results implicated a role of overreactive IgA responses in AMD pathogenesis. © 2016 Elsevier GmbH.
Gao Z.-Y.,Guangzhou No. 1 Peoples Hospital |
Jin M.,Guangzhou No. 1 Peoples Hospital |
Zhu Y.-X.,Guangzhou No. 1 Peoples Hospital
International Journal of Ophthalmology | Year: 2010
• AIM: To discuss the curative effect of pubescent coccineus colquhounia flower tablet on iridocyclitis. • METHODS: Eighty-nine patients with iridocyclitis referred to our hospital from Jan. 2006 to Dec. 2007 were divided into two groups, treatment group 45 cases (pubescent coccineus colquhounia flower and glucocorticoids) and control group 44 cases (glucocorticoids and placebo). • RESULTS: Cure rate in 14 days of treatment group and control group was 88%, 60% respectively, there was significant difference between them(P<0.05). Following up of 12 months, we found that the recurrent rate of control group was 17%, recurrent rate of treatment group was 8%, there was significant difference between them (P<0.05). • CONCLUSION: Pubescent coccineus colquhounia flower can treat iridocyclitis. And its cure rate and recurrent rate are better than those of glucocorticoids only.