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Guangzhou, China

Fang Z.,CAS Guangzhou Institute of Biomedicine and Health | Huang J.,CAS Guangzhou Institute of Biomedicine and Health | Huang J.,Hefei University of Technology | Lie P.,CAS Guangzhou Institute of Biomedicine and Health | And 6 more authors.
Chemical Communications | Year: 2010

A lateral flow nucleic acid biosensor based on copper-dependent DNA-cleaving DNAzyme and gold nanoparticles has been developed for the visual detection of copper ions (Cu2+) in an aqueous solution with a detection limit of 10 nM. © 2010 The Royal Society of Chemistry. Source


Jiang C.Q.,Guangzhou No.12 Hospital
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2010

To examine the dose-response relationship of smoking status with carotid atherosclerosis in 959 relatively healthy Chinese men. 959 older Chinese men were selected from Guangzhou Biobank Cohort Study (GBCS) on cardiovascular disease. Personal histories were collected and fasting plasma glucose and lipids, blood pressure, and common carotid artery intima-median thickness (CCA-IMT) were measured. (1) Composition of the cases: 39.1% were non-smokers, 25.7% were former smokers and 35.2% were current smokers. The mean (95% confidence interval) carotid IMT was 0.78 (0.77 - 0.79) mm. 18.4% of the subjects had carotid IMT equal to or thicker than 1.0 mm while 34.1% had carotid plaque. (2) After adjusting for age, sex, physical activity, body mass index, fasting glucose, triglyceride, high-density lipoprotein cholesterol, systolic and diastolic blood pressure, compared to never smokers, current smokers had significantly increased risk for thicker IMT and carotid plaque [odds ratio (OR) = 1.82, 95%CI: 1.30 - 2.55 and OR = 1.95, 95%CI: 1.38 - 2.75, respectively, all P < 0.001]. The risk for thicker IMT and carotid plaque increased with the increasing amount (cigarettes/day) and duration of smoking (years) as well with cigarette pack-years (P for trend all ≤ 0.01). An elevated risk with a clear dose-response relationship was found between cigarette smoking and carotid atherosclerosis. Quitting smoking or reducing the amount of smoking may lower the risk of atherosclerosis, preventing and controlling the occurrence of cardiovascular diseases, and reducing the related cardiovascular mortalities. Source


Zeng W.F.,Guangzhou No.12 Hospital
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases | Year: 2012

To explore the effects of noise exposure level and cumulative noise exposure (CNE) on the relationship between rs2070424 and rs10432782 SNPs in SOD1 and the susceptibility to noise-induced hearing loss (NIHL). A case-control study was performed for investigating the effects of environmental risk factors on the susceptibility to NIHL in 201 sensitive workers and 202 resistant workers.A questionnaire was utilized to investigate the occupational health and to identify the occupational risk factors. The noise exposure levels were detected according to the Chinese standard Measurement of noise in the workplace (GBZ/T 189.8-2007). The peripheral blood samples (5 ml blood for each sample) were from sensitive workers and resistant workers. Genomic DNA was extracted on the basis of the standard procedures of Takara kit. SNPs were detected using standard procedures of TaqMan probe allele identification method. In group exposed to 85 - 92 dB noise (A), the risk of NIHL in the subjects with the AA genotype of rs2070424 was lower than that in the subjects with the GG genotype, OR = 0.37 (95%CI: 0.17∼ 0.80). In group exposed to > 82 dB CNE (A), the AA genotype of rs2070424 is a protective factor of NIHL, as compared with the GG genotype, OR = 0.25 (95%CI: 0.09 ∼ 0.70). In group exposed to 85 - 92 dB noise (A), the risk of NIHL in the subjects with the GG genotype of rs10432782 was compared with the risk of NIHL in the subjects with the TT genotype, OR = 3.17 (95%CI: 1.16 ∼ 6.89). The GT genotype was compared with TT genotype, OR = 2.39 (95%CI: 1.16 ∼ 4.97). In group exposed to 75 ∼ 82 dB CNE (A), the risk of NIHL in the subjects with the GG genotype was compared with the risk of NIHL in the subjects with the TT genotype, OR = 2.35 (95%CI: 0.96 ∼ 5.72), P = 0.06. The GG genotype may bea risk factor of NIHJ. The noise exposure level and CNE may influence the relationship between rs2070424, rs10432782 SNPs in SOD1 and noise-induced hearing loss. Source


Xu L.,University of Hong Kong | Jiang C.Q.,Guangzhou No.12 Hospital | Cheng K.K.,University of Birmingham | Yeung S.L.R.A.,University of Hong Kong | And 4 more authors.
PLoS ONE | Year: 2015

Background Observational studies and small intervention studies suggest alcohol raises gamma-glutamyltransferase (GGT). We used Mendelian randomization to assess the causal effect of alcohol use on GGT in older Chinese people. Methods An instrumental variable (IV) analysis in 2,321 men and 2,757 women aged 50+ years from phase 3 of the Guangzhou Biobank Cohort Study with ALDH2 (rs671) genotyped, alcohol use and GGT available was used to assess the causal effect of alcohol use on GGT. Rs671 was used as an IV and F-statistics was used to test for weak instrument hypothesis. An Fstatistic of ≥10 indicates the IV is not weak. Results In men, the F-statistic for rs671 on alcohol use was 70. Using IV analysis alcohol use increased GGT by 10.60 U/L per alcohol unit (10 gram ethanol) per day (95% confidence interval (CI) 6.58 to 14.62). The estimate was lower in observational multivariate regression: 3.48 U/L GGT per alcohol unit per day (95% CI 2.84 to 4.11) adjusted for age, education, physical activity and smoking. In women, rs671 was not associated with alcohol or GGT and the F-statistic was 7 precluding IV analysis. Conclusion In Mendelian randomization, we found confirmative evidence that alcohol use increases GGT among Southern Chinese men. Moreover, we found that the ALDH2 variant rs671 was not associated with GGT among Southern Chinese women who generally consume very low levels of alcohol. Taken together our findings strongly suggest that alcohol increases GGT, although we cannot rule out the possibility that other unknown factors may cause a different relation between alcohol and GGT in other populations. © 2015 Xu et al. Source


Xu L.,University of Hong Kong | Jiang C.Q.,Guangzhou No.12 Hospital | Schooling C.M.,University of Hong Kong | Schooling C.M.,CUNY - Hunter College | And 3 more authors.
Preventive Medicine | Year: 2014

Objective: To recalibrate and modify the Framingham diabetes mellitus (DM) function and establish a simple point score for predicting near-term incident diabetes in a large sample of Chinese. Methods: A total of 16,043 participants aged 50. years or above without diabetes at baseline from the Guangzhou Biobank Cohort Study (GBCS) were recruited from 2003 to 2008 and followed up until 31 December 2012, with an average follow-up period of 4.1. years. A randomly selected sub-sample of 8000 participants was used to calculate the predictive model and the remaining sample including 8043 participants was used for validating the prediction model. Results: During follow-up, 5.2% (95% confidence interval (CI) 4.6-5.9) of men and 5.2% (95% CI 4.8-5.6) of women developed diabetes. A GBCS point score prediction model was constructed based on the Framingham DM function risk factors using the randomly selected sub-sample. Compared with the Framingham DM risk score (AUC 0.740, 95% CI 0.715-0.766), the GBCS point score prediction model predicted the development of diabetes well, with an AUC of 0.779 (95% CI 0.756-0.801, P for comparison <. 0.001). Validation analysis showed that the new GBCS function had satisfactory predictive ability for actual DM incidence and improved the calibration substantially. The original Framingham DM score underestimated diabetes incidence in the GBCS sample. Conclusions: The constructed GBCS point score prediction model based on GBCS coefficients could be more useful for identifying high risk individuals in Chinese populations than the original Framingham DM score. © 2014 Elsevier Inc. Source

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