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Lv J.-J.,CAS Kunming Institute of Botany | Lv J.-J.,University of Chinese Academy of Sciences | Xu M.,CAS Kunming Institute of Botany | Wang D.,CAS Kunming Institute of Botany | And 5 more authors.
Journal of Natural Products | Year: 2013

Six new bisbenzylisoquinoline alkaloids (1-6) and seven known compounds (8-14) were isolated from the tubers of Stephania epigaea, in addition to the major alkaloid, cepharanthine (7). The structures of 1-6 were elucidated by combined spectroscopic data analysis and chemical methods, with their configurations determined from their optical rotation values and confirmed using circular dichroism. Compounds 1-6 belong to the oxyacanthine type of bisbenzylisoquinoline alkaloids and have a rare methylenedioxy substituent. Compound 1, a dimer composed of benzylisoquinoline and seco-aristolactam units, represents a new type of bisbenzylisoquinoline alkaloid, while compounds 3-6 are bisbenzylisoquinoline N-oxides. These compounds were evaluated for their in vitro cytotoxicities against six human cancer cell lines (A-549, ECA109, HL-60, MCF-7, SMMC-7721, and SW480). Cepharanthine (7), the major component of S. epigaea, exhibited cytotoxicity against all of these cancer cell lines except ECA109, while its known analogue, 10, displayed cytotoxicity against all six cancer cell lines. © 2013 The American Chemical Society and American Society of Pharmacognosy. Source


Zhao J.-Q.,CAS Kunming Institute of Botany | Zhao J.-Q.,University of Chinese Academy of Sciences | Lv J.-J.,CAS Kunming Institute of Botany | Lv J.-J.,University of Chinese Academy of Sciences | And 8 more authors.
Tetrahedron Letters | Year: 2013

Three structurally interesting new diterpenoids, phyllanflexoids A-C (1-3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1-3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5 μM, respectively. © 2013 Elsevier Ltd. All rights reserved. Source


Zhou M.,CAS Kunming Institute of Botany | Zhou M.,University of Chinese Academy of Sciences | Xu M.,CAS Kunming Institute of Botany | Ma X.-X.,CAS Kunming Institute of Botany | And 5 more authors.
Planta Medica | Year: 2012

Two new sulfur-containing triterpenoid saponins, asprellanosides A (1) and B (2), were isolated from the roots of Ilex asprella, together with 10 known compounds (3-12). An in vitro anti-HSV-1 activity test of the isolates (1-4, 6-7, and 9-12) showed that only asprellanoside A (1) and oblonganoside H (6) exhibited anti-HSV-1 activity with TIC values of 0.14 and 0.18mM, respectively. © Georg Thieme Verlag KG Stuttgart New York. Source

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