Guangzhou Military Guangzhou General Hospital

Guangzhou, China

Guangzhou Military Guangzhou General Hospital

Guangzhou, China
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Liu H.-X.,Armed Police Corps Hospital of Guangdong | Liu H.-X.,Southern Medical University | Bai Y.-F.,Southern Medical University | Wang W.,Guangzhou Military Guangzhou General Hospital | Guo L.-L.,Armed Police Corps Hospital of Guangdong
Journal of Jilin University Medicine Edition | Year: 2014

Objective: To investigate the mRNA expression levels of epidermal growth factor receptor (EGFR) and leucine-rich repeats and immunoglobulin like domains 1 (LRIG1) in peripheral blood from the patients with non-small cell lung cancer (NSCLC), and to analyze their possible associations with the clinicopathological parameters of the patients and provide basis for treatment of NSCLC. Methods: The expression levels of EGFR and LRIG1 mRNA were detecteded in peripheral blood of 69 NSCLC patients by quantitative real-time PCR method. The associations between the gene expression levels and the clinical stage of tumor, age, gender, and survival time of the patients were analyzed. Results: Compared with normal people, the expression level of LRIGI mRNA in peripheral blood of NSCLC patients was decreased and that of EGFR was increased (P<0.001). The expression levels of LRIG1 and EGFR mRNA were not associated with gender, age, and histology of the patients (P>0.01), but they were correlated with the survival time and clinical stage of tumor of the patients (P<0.001). The Cox regression analysis results indicated that the clinical stage of tumor, the expression levels of LRIGI and EGFR mRNA were independent prognostic factors for the NSCLC patients. The later the clinical stage was, the worse the prognosis was (P = 0.028): the relative risk degree (RR) = 1.548, 95% CI: 1.074-2.283; the higher the LRIGI expression was, the better the prognosis of patients was (P = 0.026), RR = 0.242, 95% CI; 0.069-0.843; the higher the expression of EGFR mRNA was, the worse the prognosis was (P = 0.027), RR = 3.732, 95% CI: 1.165-11.956. The survival time of the patients with high expression of LRIG1 mRNA was longer than the patients with lower expression of LRIGI mRNA (χ2 = 56.560, P<0.001); the survival time of the patients with high expression of EGFR mRNA was shorter than the patients with low expression of EGFR mRNA (χ2 = 51.962, P<0.001). The expression levels of LRIG1 and EGFR mRNA in the blood sample of the same patient were negatively related (r= -0.307, P = 0.016). Conclusion: LRIG1 can affect the clinical stage and survival time of NSCLC patients by negatively regulating the expression of EGFR. LRIG1 may affect the curative effectiveness and prognosis of NSCLC patients by regulating the expression of EGFR.

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