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Guangzhou, China

Xu K.,Guangzhou Fuda Cancer Hospital | Li J.,Peking Union Medical College | Zhang C.,Guangzhou Fuda Cancer Hospital | Chen J.,Guangzhou Fuda Hospital | And 10 more authors.
Pancreas | Year: 2013

ABSTRACT: We report 2 cases of familial multiple endocrine neoplasia type 1 syndrome (MEN 1) in related Malaysian Chinese individuals: the son had simultaneous primary lesions in the pancreatic tail, parathyroid, adrenal gland, and hypophysis, with metastatic tumors in the left lung, mediastinum and spine; his mother had simultaneous primary lesions in the pancreatic head, parathyroid, and hypophysis, with metastatic tumors in the liver, spine, ilium, chest wall, and rib. Genetic testing of the 2 patients showed the same mutation in exon 9 of MEN1 (c.1288G>T, Glu430, encoding a stop codon). The tumors with the poorest prognosis and clinical sequelae were in the pancreas of both patients, and these were treated by percutaneous cryoablation. The number of hypoglycemic episodes in the son improved for more than 120 days, and the abdominal space occupying lesion resolved in his mother. Copyright © 2013 Lippincott Williams & Wilkins.

Li J.,Guangzhou Fuda Cancer Hospital | Chen J.,Guangzhou Fuda Hospital | Zhou L.,Guangzhou Fuda Cancer Hospital | Zeng J.,Guangzhou Fuda Cancer Hospital | And 9 more authors.
Cryobiology | Year: 2012

The purpose of this study was to compare a dual-freeze protocol with a triple-freeze protocol for hepatic cryoablation in a porcine model. Eighteen cryoablations were performed over an exposed operation field in nine normal porcine livers, using dual- (10-5-10-5) and triple-freeze (5-5-5-5-10-5) protocols. Changes in the temperature of the cryoprobes and the diameter of the iceballs were recorded during the ablation, and pathological changes in the cryozones (zones of tissue destruction) were assessed seven days after the procedure. Use of two and three freeze-thaw cycles produced iceballs of different diameters. Seven days after cryosurgery, the triple-freeze protocol was associated with a larger zone of complete necrosis than the dual-freeze protocol, although the two protocols produced cryozones and cryolesions of similar length, and in both cases the cryozones contained five areas of destruction. With the same freezing time (20. min), the triple-freeze protocol may be a more powerful liver ablation method than the dual-freeze protocol. © 2012 Elsevier Inc..

Li J.,Clinical Laboratory of Guangzhou Fuda Cancer Hospital | Zhou L.,Clinical Laboratory of Guangzhou Fuda Cancer Hospital | Chen J.,Guangzhou Fuda Hospital | Wu B.,Clinical Laboratory of Guangzhou Fuda Cancer Hospital | And 17 more authors.
Pancreas | Year: 2012

OBJECTIVES: Pancreatic cancer is the fourth leading cause of cancer-related death. Cryosurgery has emerged as a promising new technique for treatment. Although 80% of pancreatic cancers are located in the pancreatic head, no research has been conducted on the safety and efficacy of cryosurgery for these tumors. METHODS: Two groups of Tibetan miniature pigs (n = 4 per group) underwent cryosurgery to the pancreatic head with either the deep freezing protocol (100% argon output) or shallow freezing protocol (10% argon output), and compared to sham-operated pigs. RESULTS: Serum inflammatory factors and amylase increased during the 5 days after cryoablation in both groups but acute pancreatitis did not occur. Adhesions were observed between the pancreatic head and adjacent organs, and only minor trauma was caused to the stomach, duodenum, small intestine, and liver. Ice balls with a radius of 0.5 cm beyond the tumor edge were sufficient to cause complete necrosis of the pancreatic tissue, and decreased the degree of cold injury to surrounding tissues. CONCLUSIONS: Shallow freezing protocol seemed to be safer than, and just as effective as, the deep freezing protocol. This preliminary study suggests that cryosurgery could potentially be an effective treatment of cancer of the pancreatic head. Copyright © 2012 by Lippincott Williams & Wilkins.

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