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Liang C.-Z.,Anhui Medical University | Hao Z.-Y.,Anhui Medical University | Li H.-J.,Peking Union Medical College | Wang Z.-P.,Lanzhou University | And 10 more authors.
Urology | Year: 2010

OBJECTIVES: Chronic pelvic pain syndrome is a common and serious health problem affecting the quality of life of men. We evaluated the prevalence of premature ejaculation (PE) in Chinese men with chronic pelvic pain syndrome and studied its correlation to chronic prostatitis. METHODS: A total of 15 000 men (aged 15-60 years) were randomly recruited to take part in a survey to provide questionnaire-elicited information for sociodemographics, sexual function, National Institutes of Health-Chronic Prostatitis Symptom Index, and International Index of Erectile Function 5-item questionnaire. The eligible subjects of the present investigation were married with sexual activity. RESULTS: Responses were collected from 12 743 men (84.95%). Of these men, 1071 (8.4%) reported having prostatitis-like symptoms. The incidence of chronic prostatitis was 4.5% (n = 571) for the entire group. Of the 7372 eligible men, the incidence of prostatitis-like symptoms, chronic prostatitis, and PE was 10.5% (n = 771), 5.0% (n = 370), and 15.3% (n = 1127), respectively. The group with PE had worse National Institutes of Health-Chronic Prostatitis Symptom Index scores (P < .05) and lower International Index of Erectile Function 5-item questionnaire scores (P < .05) than the patients without PE. Also, the percentage of prostatitis-like symptoms in the PE group was greater than that in the non-PE group (P < .05). The prevalence of PE was 64.1% and 36.9% in the prostatitis-like symptom and chronic prostatitis group, respectively, of the 7372 eligible men. CONCLUSIONS: The results of our study showed a high prevalence of PE in patients with chronic prostatitis. An examination of the prostate, physically and microbiologically, should be considered during the assessment of patients with PE. © 2010 Elsevier Inc.


Hao Z.-Y.,Anhui Medical University | Li H.-J.,Peking Union Medical College | Wang Z.-P.,Lanzhou University | Xing J.-P.,Xian Jiaotong University | And 6 more authors.
Journal of Andrology | Year: 2011

This study was performed to evaluate the prevalence of erectile dysfunction (ED) and to explore its correlation to chronic prostatitis in China. A cross-sectional investigation from a large cohort study of Chinese men was used in this survey. A questionnaire consisting of general information regarding socio-demographics, chronic disease history, sexual function, the National Institutes of Health-Chronic Prostatitis Symptom Index, and the International Index of Erectile Function-5 (IIEF-5) was administered to 15 000 Chinese men aged from 15 to 60. The prevalence of ED was determined from the patient's self-evaluation and IIEF-5 score. The eligible individual both was married and had intercourse experience. In total, there were 12 743 respondents, giving a response rate of 84.95%. Among 7372 eligible men, ED prevalence as assessed by self-report and IIEF-5 score was 12.0% and 17.1%, respectively. Among 771 men with prostatitis-like symptoms, ED prevalence as assessed by self-report and IIEF-5 score was 39.3% and 30.1%, respectively. Among 370 men suffering from chronic prostatitis, ED prevalence as assessed by self-report and IIEF-5 score was 40.5% and 35.1%, respectively. The prevalence of self-reported and IIEF-5 score-assessed ED had high correlation with increasing age among all eligible men, men with prostatitis-like symptoms, and men with chronic prostatitis (Pt<.05, Ps<.05, Pcp<.05). ED prevalence as assessed by both self-report and IIEF-5 score was higher in men with prostatitis-like symptoms and with chronic prostatitis than in the general group (Ps<.05, Pcp<.05). The prevalence of ED was higher in the prostatitis population than in the general population with either self-reported or IIEF-5 score assessment. The prevalence was higher with self-reported than with IIEF-5 assessment in men with prostatitis. Estimates of ED prevalence among men with prostatitis should not rely on self-reporting alone in that this is likely to overestimate the true prevalence. © American Society of Andrology.


Liu Z.-H.,Guangzhou Army General Hospital | Xiao Y.,Guangzhou Army General Hospital
Journal of Leukemia and Lymphoma | Year: 2010

CD4 + CD25 + regulatory T cell (CD4 + CD25 + Treg) is a unique T-cell subsets with immune regulation function. Natural CD4 + CD25 + Treg originates from the thymus and acquired CD 4 + CD25 + Treg can be induced from CD4 + CD25 - T cells in peripheral blood. A specific transcription inhibitory factor-Foxp3 can be expressed , besides, it also can express other membrane molecules, such as CD4, CD25, CTLA-4 (CD152), GITR, etc. Its main function is immunosuppression and immune energy. Recent research finds that it over-expresses in some non-Hodgkin lymphoma, and the number of CD 4 + CD25 + Treg increases as tumor progression. The increased CD4 + CD25 + Treg can accelerate tumor growth and recurrence, and inhibit effector T cells (CD4 + T cells or CD8 + T cells), which makes it probably play a role in tumor immune escape mechanisms. In this article, the recent research results of CD 4 + CD25 + Treg in T cell non-Hodgkin lymphoma (mainly cutaneous T-cell lymphoma and adult T-cell lymphoma) were reviewed.


Junrong T.,Guangzhou Army General Hospital | Huancheng Z.,Southern Medical University | Feng H.,Guangzhou Army General Hospital | Yi G.,Southern Medical University | And 9 more authors.
Journal of Biosciences | Year: 2011

Hepatocellular carcinoma (HCC), among the most common malignancies worldwide, remains a major threat to public health, and there is an urgent need to identify novel biomarkers for diagnosis, prognosis and targets for anti-cancer treatment. In this study, two-dimensional polyacrylamide gel electrophoresis coupled with ESI-Q-TOF MS/MS analysis was used to identify differentially expressed proteins among the HCC tumour centre, tumour margin and nontumourous liver tissues. In total, 52 spots with significant alteration were positively identified by MS/MS analysis. Altered expression of representative proteins, including CIB1, was validated by Western blotting. Immunostaining suggested an increase tendency of CIB1 expression from nontumourous liver tissue to tumour centre. Knockdown of CIB1 expression by RNA interference led to the significant suppression of the cell growth in hepatoma HepG2 cells. These data suggest that CIB1 may be used as a novel prognostic factor and possibly an attractive therapeutic target for HCC. © 2011 Indian Academy of Sciences.

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