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Chen S.K.,Guangxi Maternal and Child Health Hospital
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2011

To investigate the association between obesity and prevalence of metabolic syndrome (MS) with its associated risk factors, in children and adolescents. A stratified random sampling method was used to select 7893 students from 6 to 18 years of age from 14 out of 396 primary and secondary schools in Nanning city. All the students had undergone physical examination and blood tests including the following risk factors related to metabolic syndrome: fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), alanine amino shift enzyme (ALT), aspartic acid amine shift enzyme (AST) and fasting insulin (FINS). The homeostasis model assessment insulin resistance index (HOMA-IR) was also measured. (1) The prevalence rate of MS in normal group was 0.57%. In both the overweight and obesity groups, the prevalence rates of MS were 4.53% and 26.80%, respectively. (2) These indices in obesity group were higher than other two groups (P < 0.05). The result of overweight group was higher than normal group (P < 0.05). (3) Waist circumference (OR = 1.087, 95%CI: 1.033 - 1.143), SBP (OR = 1.073, 95%CI: 1.032 - 1.116), FBG (OR = 1.394, 95%CI: 1.568 - 3.423), TG (OR = 3.213, 95%CI: 1.410 - 7.319) and HDL-C (OR = 0.001, 95%CI: 0.000 - 0.012) were detecting indices which had statistically significant with MS in binary logistic regression analysis. Metabolic syndrome and obesity were closely related in children and adolescents while its prevalence and risk factors increased with the severity of obesity.

Han S.,Nanjing Medical University | Yu Z.,Nanjing Medical University | Liu L.,Guiyang Maternal and Child Health Hospital | Wang J.,Fudan University | And 7 more authors.
Pediatrics | Year: 2015

OBJECTIVES: To develop and validate a predischarge risk stratification model by using transcutaneous bilirubin (TcB) values and clinical factors to predict significant postdischarge hyperbilirubinemia in healthy term and late preterm Chinese neonates. METHODS: In a prospective cohort study, 8215 healthy term and late preterm neonates in 8 hospitals in China underwent TcB measurement at <168 hours of age. TcB percentiles were calculated and used to develop an hour-specific nomogram, and 9 empirically weighted items were used to derive a prediction model. A risk stratification model was developed by combining the TcB nomogram with clinical risk scores to predict significant hyperbilirubinemia, defined as a postdischarge bilirubin level that exceeded the hour-specific recommended threshold value for phototherapy. Data from another 13 157 neonates were used to validate the model. RESULTS: A TcB nomogram for every 12 hours of the studied interval was constructed from the development set. Gestational age, male gender, history of previous neonate who received phototherapy, bruising, feeding mode, weight loss, and early discharge were predictors of postdischarge significant hyperbilirubinemia. The combination of the TcB nomogram and clinical risk score provided the best prediction of significant hyperbilirubinemia with an area under the curve of 0.95 (95% confidence interval: 0.94-0.95) in the development data set and 0.94 (95% confidence interval: 0.93-0.94) in the validation data set. A risk stratification model with 6 distinct risk levels was developed and validated. CONCLUSIONS: A risk classification model, combining discharge transcutaneous bilirubin values and clinical risk factors, separated term and late preterm Chinese neonates into 6 risk classes for the timely follow-up of postdischarge hyperbilirubinemia detection. Copyright © 2015 by the American Academy of Pediatrics.

Li X.,Central South University | Zhou Q.,Central South University | Zhang M.,Central South University | Tian X.,Guangxi Maternal and Child Health Hospital | Zhao Y.,Central South University
Journal of Ultrasound in Medicine | Year: 2015

α-Thalassemia prevails in Southeast Asia, where α-thalassemia major is a lethal type. Sonography is a helpful and cost-effective screening tool for detecting α-thalassemia major fetuses. The cardiothoracic ratio, placental thickness, and middle cerebral artery peak systolic velocity are most used in clinical practice. These sensitive markers are helpful for evaluation of the hemodynamic status and cardiovascular function of the affected fetuses. They can predict fetal α-thalassemia major and assess the efficacy of treatment noninvasively; therefore, the medical costs as well as the possibility of fetal loss caused by invasive procedures can be reduced. Other potentially useful sonographic markers need further studies, although previous preliminary research suggests their usefulness. This article will review those sonographic markers. ©2015 by the American Institute of Ultrasound in Medicine

Sun L.,Beijing Hospital and Beijing Institute of Geriatrics | Hu C.-Y.,JiangBin Hospital | Shi X.-H.,Beijing Hospital and Beijing Institute of Geriatrics | Zheng C.-G.,Guangxi Maternal and Child Health Hospital | And 8 more authors.
PLoS ONE | Year: 2013

Background:The I405V polymorphism of the cholesteryl ester transfer protein gene (CETP) has been suggested to be a protective factor conferring longevity in Ashkenazi Jews, although findings in other races are not supportive. This paper describes a case-control study and a meta-analysis conducted to derive a more precise estimation of the association between CETP 405V and longevity.Methods:We enrolled 1,021 ethnic Han Chinese participants (506 in the longevity group and 515 controls), then performed a meta-analysis that integrated the current study and previously published ones. Pooled odds ratios (OR) were calculated for allele contrasts, dominant and recessive inheritance models to assess the association between CETP 405V and longevity according to the ethnic stratification.Results:Our case-control data indicated that CETP 405V is a longevity risk allele in all genetic models (Padditive=0.008; Pdominant=0.008, ORdominant=0.673; Precessive=0.017, ORrecessive=0.654) after adjustment for the apolipoprotein E (APOE) ε4 allele, body mass index and high-density lipoprotein cholesterol. A synergy was detected between 405V and APOE ε4 (P=0.001, OR=0.530). Eight studies were eligible for meta-analysis, which confirmed 405V is the risky allele against longevity in all genetic models: allele contrasts (OR=0.81, 95%CI=0.74-0.88), dominant model (OR=0.72, 95%CI=0.64-0.82) and recessive model (OR=0.80, 95%CI=0.67-0.96). After ethnic stratification, 405V remained a risk allele in East Asians but no significant association was found in Europeans or white Americans.Conclusion:Our case-control study suggests CETP 405V as a risk allele against longevity in Chinese. The meta-analysis suggests the involvement of CETP 405V is protective in Ashkenazi Jews but is a risk allele against longevity in the East Asian (Chinese) population. © 2013 Sun et al.

Sun L.,Beijing Hospital and Beijing Institute of Geriatrics | Lin J.,University of Chinese Academy of Sciences | Du H.,University of Science and Technology Beijing | Hu C.,JiangBin Hospital | And 6 more authors.
BioMed Research International | Year: 2014

Human longevity is always a biological hotspot and so much effort has been devoted to identifying genes and genetic variations associated with longer lives. Most of the demographic studies have highlighted that females have a longer life span than males. The reasons for this are not entirely clear. In this study, we carried out a pool-based, epigenome-wide investigation of DNA methylation profiles in male and female nonagenarians/centenarians using the Illumina 450 K Methylation Beadchip assays. Although no significant difference was detected for the average methylation levels of examined CpGs (or probes) between male and female samples, a significant number of differentially methylated probes (DMPs) were identified, which appeared to be enriched in certain chromosome regions and certain parts of genes. Further analysis of DMP-containing genes (named DMGs) revealed that almost all of them are solely hypermethylated or hypomethylated. Functional enrichment analysis of these DMGs indicated that DNA hypermethylation and hypomethylation may regulate genes involved in different biological processes, such as hormone regulation, neuron projection, and disease-related pathways. This is the first effort to explore the gender-based methylome difference in nonagenarians/centenarians, which may provide new insights into the complex mechanism of longevity gender gap of human beings. © 2014 Liang Sun et al.

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