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Jiang T.,Guangxi Medical University | Jiang T.,Guangxi Key Laboratory of Regenerative Medicine | Zhao J.,Guangxi Medical University | Zhao J.,Guangxi Key Laboratory of Regenerative Medicine | And 8 more authors.
PLoS ONE | Year: 2015

Study Strategy: A retrospective clinic study. Purpose: To evaluate the efficacy of conservative and surgical treatment for lumbosacral tuberculosis. Methods: This study retrospectively reviewed 53 patients with lumbosacral tuberculosis who were treated in our institution between January 2005 and January 2011. There were 29 males and 24 females with average ages of 37.53 ± 17.28 years (range 6-72 years). 11 patients were given only anti-TB drugs; the remainder underwent anterior debridement, interbody fusion with and without instrumentation, or one-stage anterior debridement combined with posterior instrumentation. Outcome data for these patients included neurologic status, lumbosacral angle, erythrocyte sedimentation rate value(ESR) and C-reactive protein value (CRP) were assessed before and after treatment. Results: The mean lumbosacral angles were 23.00°±2.90° in the conservatively treated patients and 22.36°±3.92o in the surgically treated patients. At the final follow-up, this had improved to 24.10o ± 2.96° in the conservatively treated patients and 28.13°± 1.93° in the surgically treated patients (all P < 0.05). There were statistically significant differences before and after treatment in terms of ESR and CRP (all P < 0.05). All patients achieved bone fusion. The mean follow-up period was 32.34 ± 8.13 months (range 18 to 55 months). The neurological deficit did not worsen in any of the patients. Conclusions: It has been proven that conservative and surgical treatments are safe and effective and produce good clinical outcomes for patients with lumbosacral tuberculosis. The advantages of operation include thoroughness of debridement, decompression of the spinal cord, and adequate spinal stabilization. © 2015 Jiang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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