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Luo Y.,Guangxi Medical University | Luo Y.,Guangxi Key Laboratory of Genomic and Personalized Medicine | Luo Y.,Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine | Zhang H.,Guangxi Medical University | And 35 more authors.
Journal of Sexual Medicine | Year: 2015

Introduction: The decline of testosterone has been known to be associated with the prevalence of erectile dysfunction (ED), but the causal relationship between sex hormones and ED is still uncertain. Aim: To prove the association between sex hormones and ED, we carried out a prospective cohort study based on our previous cross-sectional study. Methods: We performed a prospective cohort study of 733 Chinese men who participated in Fangchenggang Area Males Health and Examination Survey from September 2009 to December 2009 and were followed for 4 years. Erectile function was estimated by scores of the five-item International Index of Erectile Dysfunction (IIEF-5) and relative ratios (RRs) were estimated using the Cox proportional hazards regression model. Main Outcome Measures: Data were collected at follow-up visit and included sex hormone measurements, IIEF-5 scores, physical examination, and health questionnaires. Results: Men with the highest tertile of free testosterone (FT) (RR=0.21, 95% confidence interval [CI]: 0.09-0.46) and the lowest tertile of sex hormone-binding globulin (SHBG) (RR=0.38, 95% CI: 0.19-0.73) had decreased risk of ED. In young men (aged 21-40), a decreased risk was observed with the increase of FT and bioavailable testosterone (BT) (adjusted RR and 95% CI: 0.78 [0.67-0.92] and 0.75 [0.62-0.95], respectively). Total testosterone (TT) (RR=0.89, 95% CI: 0.81-0.98) was inversely associated with ED after adjusting for SHBG, while SHBG (RR=1.04, 95% CI: 1.02-1.06) remained positively associated with ED after further adjusting for TT. Men with both low FT and high SHBG had highest ED risk (adjusted RR=4.61, 95% CI: 1.33-16.0). Conclusions: High FT and BT levels independently predicted a decreased risk of ED in young men. Further studies are urgently needed to clarify the molecular mechanisms of testosterone acting on ED. © 2015 International Society for Sexual Medicine.

Chen D.,Guangxi Medical University | Chen D.,Guangxi Key Laboratory of Genomic and Personalized Medicine | Chen D.,Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine | Zhang H.,Guangxi Medical University | And 20 more authors.
Clinica Chimica Acta | Year: 2015

Background: It is controversial whether serum uric acid (SUA) is a risk factor for the prevalence of metabolic syndrome (MetS). The current study was designed to highlight the association of SUA and MetS and its components. Methods: Data on 3675 healthy male subjects, aged 17-88. years, were collected for the cross-sectional study. A representative sample of 2575 individuals who did not suffer from MetS at baseline was involved in the cohort study. A cox regression model was applied to evaluate causality for the 2- and 4-year large scale longitudinal study. Results: In the cross-sectional analysis, SUA showed a statistically significant negative correlation with high-density lipoprotein cholesterol (HDL-c) and a positive correlation with blood pressure (BP), triglycerides (TG), waist circumference (WC), and body mass index (BMI) (all P<. 0.001). In longitudinal analysis, examining the risk of developing MetS, SUA concentrations (hazard ratios comparing fourth quartile to the first quartile of 1.75; 95% CI, 1.26-2.41) were positively associated with incident MetS after adjusted for age, blood pressure, glucose, TG, HDL-c, smoking, alcohol drinking and education. Conclusion: SUA is positively correlated with the prevalence of MetS. Increased SUA concentration may be an independent risk factor for MetS. © 2015 Published by Elsevier B.V.

Liao M.,Guangxi Medical University | Liao M.,Guangxi Key Laboratory of Genomic and Personalized Medicine | Liao M.,Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine | Liao M.,University of Pennsylvania | And 21 more authors.
Mediators of Inflammation | Year: 2015

Osteocalcin (OCN) was potentially associated with inflammatory factors, so we explored the metabolic role in this association in general population. Our findings suggest that OCN was positively associated with IgG while inversely associated with C3, both of which were probably mediated by obesity. Moreover, serum OCN was inversely associated with hsCRP in men with impaired fasting glucose, hyperglycemia, or metabolic syndrome, while its association with IgE was significantly observed in men with a normal metabolic profile. © 2015 Ming Liao et al.

Tang Q.,Guangxi Medical University | Tang Q.,Guangxi Key Laboratory of Genomic and Personalized Medicine | Tang Q.,Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine | Liu Z.,Guangxi Medical University | And 20 more authors.
Diabetology and Metabolic Syndrome | Year: 2015

Background: Elevated serum ferritin levels have been reported to contribute to metabolic syndrome (MetS). We examined the association of serum ferritin levels with the development of MetS in a representative sample of Chinese male adult population. Method: The data came from the 2009-2013 Fangchenggang Area Males Health and Examination Survey (FAMHES). We combined a cross-sectional study of 2417 males and a longitudinal study of 857 males who participated in the FAMHES. Result: The serum ferritin level of MetS was higher than that of nonMetS (median and percentiles 25-75: 447.4 (294.1-612.4) vs. 302.4 (215.0-435.8) ng/ml, p < 0.01). A positive correlation between ferritin concentrations and blood pressure (Systolic BP: R = 0.110, Diastolic BP: R = 0.158), waist circumference (R = 0.333), fasting glucose (R = 0.089), triglyceride (R = 0.315) and low high-density lipoprotein cholesterol (R = 0.130) was significant (all p < 0.001). Compared with the level of ferritin in the group with no MetS component, the group with all five MetS components had a higher ferritin level (554.7 (340.1-606.4) vs. 274.2 (198.2-384.4) ng/ml). The odd radio (OR) was higher for MetS in the highest ferritin quartile (OR = 2.29, 95% CI = 1.47-3.54) compared with the lowest ferritin quartile after adjustment for multi-factors. After 4-year follow up, 79 subjects newly diagnosed with MetS in 857 cohort male participants in 2013. Compared with the lowest ferritin quartile, the RR of the highest ferritin quartile was 2.55 (95% CI = 1.30-5.00) after multiple adjustments (p < 0.01). Conclusion: Our findings confirm that the serum ferritin level is associated with the independent components of MetS, and elevated ferritin level is an independent risk factor for MetS development in the Chinese male population during the 4-year follow-up period. © 2015 Tang et al.; licensee BioMed Central.

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