Guangxi Institute of Traditional Medical and Pharmaceutical science

Nanning, China

Guangxi Institute of Traditional Medical and Pharmaceutical science

Nanning, China
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Nong W.,Guangxi University | Zhao A.,Cleveland State University | Wei J.,Guangxi University | Lin X.,Guangxi Institute of Traditional Medical and Pharmaceutical science | And 2 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2017

Ten new cinnamic acid derivatives containing a 2-aminothiazole substructure were designed and synthesized. This series of compounds exhibited good thermostabilities as demonstrated by thermogravimetric analysis. In coagulation assays (prothrombin time, activated partial thromboplastin time and thrombin time) in vitro, most compounds demonstrated excellent activities to promote blood coagulation. Among the studied series, compounds N1, N4, N5 and W5 exhibited a significant coagulation activity. Further studies indicated that compound N5 (IC50 =1.87μmol/L) displayed the most suitable efficacy of promoting platelet aggregation than the clinically used haemostatic drug etamsylate (IC50 =46.22μmol/L). Furthermore, the relationship between the functional groups of the compounds and the corresponding blood coagulant activity was explored in this study. © 2017 Elsevier Ltd.


Chen S.-R.,University of Macau | Qiu H.-C.,Guangxi Institute of Traditional Medical and Pharmaceutical science | Hu Y.,University of Macau | Wang Y.,University of Macau | Wang Y.-T.,University of Macau
Phytotherapy Research | Year: 2016

Hepatocellular carcinoma (HCC) is a common malignant cancer and is the third leading cause of death worldwide. Effective treatment of this disease is limited by the complicated molecular mechanism underlying HCC pathogenesis. Thus, therapeutic options for HCC management are urgently needed. Targeting the Wnt/β-catenin, Hedgehog, Notch, and Hippo-YAP signaling pathways in cancer stem cell development has been extensively investigated as an alternative treatment. Herbal medicine has emerged as an initiative therapeutic option for HCC management because of its multi-level, multi-target, and coordinated intervention effects. In this article, we summarized the recent progress and clinical benefits of targeting the above mentioned signaling pathways and using natural products such as herbal medicine formulas to treat HCC. Proving the clinical success of herbal medicine is expected to deepen the knowledge on herbal medicine efficiency and hasten the adoption of new therapies. Copyright © 2016 John Wiley & Sons, Ltd.


Yan Y.,Guangxi Institute for Food and Drug Control | Zhang Y.-Y.,Guangxi Institute of Traditional Medical and Pharmaceutical science
Chinese Journal of New Drugs | Year: 2016

Objective:To establish a method for determining multielement in Traditional Chinese Medicine injections. Methods:After microwave digestion, 35 kinds of trace elements in the samples were determined by inductively coupled plasma mass spectrometry(ICP-MS), and the methodology was validated. Results:The calibration curves for the 35 kinds of trace elements all had good linearity, with r≥0.999 0. The limits of detections were in the range of 0.004 to 3.972 μg·L-1. The recoveries of the trace elements were between 84.35% and 107.56% with RSDs below 5%. Conclusion: This method is simple, sensitive, and precise, and can satisfy the requirement for multielement determination in traditional Chinese medicine injections. © 2016, Chinese Journal of New Drugs Co. Ltd. All right reserved.


Hu R.-C.,Guangxi Institute of Traditional Medical and Pharmaceutical science | Xu W.-B.,CAS Institute of Botany | Huang Y.-F.,Guangxi Institute of Traditional Medical and Pharmaceutical science
Nordic Journal of Botany | Year: 2016

Disporum sinovietnamicum R. C. Hu & Y. Feng Huang sp. nov. is described and from southwestern Guangxi, China. It is morphologically closest to D. jinfoshanense X. Z. Li, D. M. Zhang & D. Y. Hong, but differs by having stems that are 35-90 cm tall, narrowly lanceolate and thinly leathery leaves, and ovate and glabrous tepals. © 2016 Nordic Society Oikos.


PubMed | China Pharmaceutical University, Guangxi Institute of Traditional Medical and Pharmaceutical science and Macau University of Science and Technology
Type: Journal Article | Journal: Molecules (Basel, Switzerland) | Year: 2016

The aim of this study was to investigate the antitumor activities of


Wang L.,Guangxi University | You Y.,Guangxi University | Wang S.,Guangxi University | Liu X.,Guangxi University | And 6 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2012

Nineteen previously unreported matrine derivatives were synthesized and characterized using elemental analysis, infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and mass spectrometry. Target compounds 6a-6l and 7a-7c showed stronger inhibitory activities than matrine in the in vitro antitumor tests and inhibited the growth of the Hep7402, B16-F10, A549, and TW03 cell lines. In addition, compound 6i exhibited a potent antitumor activity similar to that of colchicine. © 2012 Elsevier Ltd. All rights reserved.


PubMed | Guangxi Medical University, Guangxi Institute of Traditional Medical and Pharmaceutical science and Guangxi University
Type: Journal Article | Journal: Molecules (Basel, Switzerland) | Year: 2016

Gallic acid (GA) and its derivatives are anti-inflammatory agents and are reported to have potent effects on Osteoarthritis (OA) treatment. Nonetheless, it is generally accepted that the therapeutic effect and biocompatibility of GA is much weaker than its esters due to the high hydrophilicity. The therapeutic effect of GA on OA could be improved if certain structural modifications were made to increase its hydrophobicity. In this study, a novel sulfonamido-based gallate was synthesized by bonding sulfonamide with GA, and its biological evaluations on OA were investigated. Results show that 5-[4-(Pyrimidin-2-ylsulfamoylphenyl)]-carbamoyl-benzene-1,2,3-triyl triacetate (HAMDC) was able to reverse the effects induced by Interleukin-1 (IL-1) stimulation, and it also had a great effect on chondro-protection via promoting cell proliferation and maintaining the phenotype of articular chondrocytes, as well as enhancing synthesis of cartilage specific markers such as aggrecan, collagen II and Sox9. Furthermore, a docking study showed that HAMDC fits into the core of the active site of a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), which provides an explanation for its activity and selectivity.


PubMed | Guangxi Institute of Traditional Medical and Pharmaceutical science, Research group Dynamyc, AP HP, Guangxi University and Henri Mondor Hospital
Type: Journal Article | Journal: Parasites & vectors | Year: 2016

The development of alternative approaches in ectoparasite management is currently required. Essential oils have been demonstrated to exhibit fumigant and topical toxicity to a number of arthropods. The aim of the present study was to assess the potential efficacy of ten essential oils against Sarcoptes scabiei.The major chemical components of the oils were identified by GC-MS analysis. Contact and fumigation bioassays were performed on Sarcoptes mites collected from experimentally infected pigs. For contact bioassays, essential oils were diluted with paraffin to get concentrations at 10, 5, and even 1% for the most efficient ones. The mites were inspected under a stereomicroscope 10, 20, 30, 40, 50, 60, 90, 120, 150, and 180min after contact. For fumigation bioassay, a filter paper was treated with 100L of the pure essential oil. The mites were inspected under a stereomicroscope for the first 5min, and then every 5min until 1h.Using contact bioassays, 1% clove and palmarosa oil killed all the mites within 20 and 50min, respectively. The oils efficacy order was: clove>palmarosa>geranium>tea tree>lavender>manuka>bitter orange>eucalyptus>Japanese cedar. In fumigation bioassays, the efficacy order was: tea tree>clove>eucalyptus>lavender>palmarosa>geranium>Japanese cedar>bitter orange>manuka. In both bioassays, cade oil showed no activity.Essential oils, especially tea tree, clove, palmarosa, and eucalyptus oils, are potential complementary or alternative products to treat S. scabiei infections in humans or animals, as well as to control the mites in the environment.


Deng Y.,CAS South China Botanical Garden | Huang Y.,Guangxi Institute of Traditional Medical and Pharmaceutical science
Phytotaxa | Year: 2012

A new name, Ophiorrhiza loana is proposed to replace Ophiorrhiza longipes H.S.Lo, a name blocked by O. longipes Craib. © 2012 Magnolia Press.


Ya Q.K.,Guangxi Institute of Traditional Medical and Pharmaceutical science
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2010

To study the chemical constituent from the antithrombus activity extract of Radix Aerio Fici Microcarpae. The isolation and purification of the extract were conducted by means of silica gel column chromatography, polyamide column chromatography and recrytallization. The structures of these compounds were elucidated based on the physicochemical properties and spectroscopic analysis. 7 compounds were isolated from the extract. They were identified as isovanillic acid (1), 4-hydroxybenzoic acid(2),3,4-dihydroxybenzoic acid (3), friedelane (4), alpha-amyrin acetate (5), lanosterol (6) and beta-sitosterol (7) . Compound 3,4 and 7 are isolated from this plant for the first time.

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