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Yan Y.,Guangxi Institute for Food and Drug Control | Zhang Y.-Y.,Guangxi Institute of Traditional Medical and Pharmaceutical science
Chinese Journal of New Drugs | Year: 2016

Objective:To establish a method for determining multielement in Traditional Chinese Medicine injections. Methods:After microwave digestion, 35 kinds of trace elements in the samples were determined by inductively coupled plasma mass spectrometry(ICP-MS), and the methodology was validated. Results:The calibration curves for the 35 kinds of trace elements all had good linearity, with r≥0.999 0. The limits of detections were in the range of 0.004 to 3.972 μg·L-1. The recoveries of the trace elements were between 84.35% and 107.56% with RSDs below 5%. Conclusion: This method is simple, sensitive, and precise, and can satisfy the requirement for multielement determination in traditional Chinese medicine injections. © 2016, Chinese Journal of New Drugs Co. Ltd. All right reserved.


Hu R.-C.,Guangxi Institute of Traditional Medical and Pharmaceutical science | Xu W.-B.,CAS Institute of Botany | Huang Y.-F.,Guangxi Institute of Traditional Medical and Pharmaceutical science
Nordic Journal of Botany | Year: 2016

Disporum sinovietnamicum R. C. Hu & Y. Feng Huang sp. nov. is described and from southwestern Guangxi, China. It is morphologically closest to D. jinfoshanense X. Z. Li, D. M. Zhang & D. Y. Hong, but differs by having stems that are 35-90 cm tall, narrowly lanceolate and thinly leathery leaves, and ovate and glabrous tepals. © 2016 Nordic Society Oikos.


PubMed | China Pharmaceutical University, Guangxi Institute of Traditional Medical and Pharmaceutical science and Macau University of Science and Technology
Type: Journal Article | Journal: Molecules (Basel, Switzerland) | Year: 2016

The aim of this study was to investigate the antitumor activities of


Wang L.,Guangxi University | You Y.,Guangxi University | Wang S.,Guangxi University | Liu X.,Guangxi University | And 6 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2012

Nineteen previously unreported matrine derivatives were synthesized and characterized using elemental analysis, infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and mass spectrometry. Target compounds 6a-6l and 7a-7c showed stronger inhibitory activities than matrine in the in vitro antitumor tests and inhibited the growth of the Hep7402, B16-F10, A549, and TW03 cell lines. In addition, compound 6i exhibited a potent antitumor activity similar to that of colchicine. © 2012 Elsevier Ltd. All rights reserved.


PubMed | Guangxi Medical University, Guangxi Institute of Traditional Medical and Pharmaceutical science and Guangxi University
Type: Journal Article | Journal: Molecules (Basel, Switzerland) | Year: 2016

Gallic acid (GA) and its derivatives are anti-inflammatory agents and are reported to have potent effects on Osteoarthritis (OA) treatment. Nonetheless, it is generally accepted that the therapeutic effect and biocompatibility of GA is much weaker than its esters due to the high hydrophilicity. The therapeutic effect of GA on OA could be improved if certain structural modifications were made to increase its hydrophobicity. In this study, a novel sulfonamido-based gallate was synthesized by bonding sulfonamide with GA, and its biological evaluations on OA were investigated. Results show that 5-[4-(Pyrimidin-2-ylsulfamoylphenyl)]-carbamoyl-benzene-1,2,3-triyl triacetate (HAMDC) was able to reverse the effects induced by Interleukin-1 (IL-1) stimulation, and it also had a great effect on chondro-protection via promoting cell proliferation and maintaining the phenotype of articular chondrocytes, as well as enhancing synthesis of cartilage specific markers such as aggrecan, collagen II and Sox9. Furthermore, a docking study showed that HAMDC fits into the core of the active site of a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), which provides an explanation for its activity and selectivity.


PubMed | Guangxi Medical University, Guangxi Institute of Traditional Medical and Pharmaceutical science and Guangxi University
Type: Journal Article | Journal: PloS one | Year: 2015

Gallic acid (GA) and its derivatives are anti-inflammatory agents reported to have an effect on osteoarthritis (OA). However, GA has much weaker anti-oxidant effects and inferior bioactivity compared with its derivatives. We modified GA with the introduction of sulfonamide to synthesize a novel compound named JEZ-C and analyzed its anti-arthritis and chondro-protective effects. Comparison of JEZ-C with its sources i.e. GA and Sulfamethoxazole (SMZ) was also performed. Results showed that JEZ-C could effectively inhibit the IL-1-mediated induction of MMP-1 and MMP-13 and could induce the expression of TIMP-1, which demonstrated its ability to reduce the progression of OA. JEZ-C can also exert chondro-protective effects by promoting cell proliferation and maintaining the phenotype of articular chondrocytes, as evidenced by improved cell growth, enhanced synthesis of cartilage specific markers such as aggrecan, collagen II and Sox9. Meanwhile, expression of the collagen I gene was effectively downregulated, revealing the inhibition of chondrocytes dedifferentiation by JEZ-C. Hypertrophy that may lead to chondrocyte ossification was also undetectable in JEZ-C groups. The recommended dose of JEZ-C ranges from 6.2510-7 g/ml to 6.2510-5 g/ml, among which the most profound response was observed with 6.2510-6 g/ml. In contrast, its source products of GA and SMZ have a weak effect not only in the inhibition of OA but also in the bioactivity of chondrocytes, which indicated the significance of this modification. This study revealed JEZ-C as a promising novel agent in the treatment of chondral and osteochondral lesions.


PubMed | Guangxi Institute of Traditional Medical and Pharmaceutical science, Research group Dynamyc, AP HP, Guangxi University and Henri Mondor Hospital
Type: Journal Article | Journal: Parasites & vectors | Year: 2016

The development of alternative approaches in ectoparasite management is currently required. Essential oils have been demonstrated to exhibit fumigant and topical toxicity to a number of arthropods. The aim of the present study was to assess the potential efficacy of ten essential oils against Sarcoptes scabiei.The major chemical components of the oils were identified by GC-MS analysis. Contact and fumigation bioassays were performed on Sarcoptes mites collected from experimentally infected pigs. For contact bioassays, essential oils were diluted with paraffin to get concentrations at 10, 5, and even 1% for the most efficient ones. The mites were inspected under a stereomicroscope 10, 20, 30, 40, 50, 60, 90, 120, 150, and 180min after contact. For fumigation bioassay, a filter paper was treated with 100L of the pure essential oil. The mites were inspected under a stereomicroscope for the first 5min, and then every 5min until 1h.Using contact bioassays, 1% clove and palmarosa oil killed all the mites within 20 and 50min, respectively. The oils efficacy order was: clove>palmarosa>geranium>tea tree>lavender>manuka>bitter orange>eucalyptus>Japanese cedar. In fumigation bioassays, the efficacy order was: tea tree>clove>eucalyptus>lavender>palmarosa>geranium>Japanese cedar>bitter orange>manuka. In both bioassays, cade oil showed no activity.Essential oils, especially tea tree, clove, palmarosa, and eucalyptus oils, are potential complementary or alternative products to treat S. scabiei infections in humans or animals, as well as to control the mites in the environment.


Deng Y.,CAS South China Botanical Garden | Huang Y.,Guangxi Institute of Traditional Medical and Pharmaceutical science
Phytotaxa | Year: 2012

A new name, Ophiorrhiza loana is proposed to replace Ophiorrhiza longipes H.S.Lo, a name blocked by O. longipes Craib. © 2012 Magnolia Press.


Ya Q.K.,Guangxi Institute of Traditional Medical and Pharmaceutical science
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2010

To study the chemical constituent from the antithrombus activity extract of Radix Aerio Fici Microcarpae. The isolation and purification of the extract were conducted by means of silica gel column chromatography, polyamide column chromatography and recrytallization. The structures of these compounds were elucidated based on the physicochemical properties and spectroscopic analysis. 7 compounds were isolated from the extract. They were identified as isovanillic acid (1), 4-hydroxybenzoic acid(2),3,4-dihydroxybenzoic acid (3), friedelane (4), alpha-amyrin acetate (5), lanosterol (6) and beta-sitosterol (7) . Compound 3,4 and 7 are isolated from this plant for the first time.


PubMed | Guangxi Institute of Traditional Medical and Pharmaceutical science and Guangxi Teachers Education University
Type: Journal Article | Journal: Applications in plant sciences | Year: 2015

Microsatellite markers were developed for Ilex kaushue (Aquifoliaceae), a medicinal plant with extremely small wild populations that exists in fragmented habitats, to assess and protect its genetic diversity.Using 454 GS FLX Titanium sequencing, 16 microsatellite primer sets were isolated and characterized. Fifteen of these markers were polymorphic. The number of alleles per locus ranged from one to nine across 22 individuals from both cultivated and wild populations. The observed and expected heterozygosity in these two populations ranged from 0.000 to 1.000 and from 0.000 to 0.785, respectively.These markers will be useful in studies on genetic diversity of I. kaushue.

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