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Zhen H.S.,Guangxi University | Liang X.L.,Guangxi University | Qiu Q.,Guangxi University | Chen L.,Guangxi University | And 2 more authors.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2013

To study the macroscopic and microscopic characteristics of Zhuang medicine Tetrastigma planicaule. Macroscopic and microscopic identification were studied. The microscopic characteristics were significant. The root had more than 10 layers of cork cells arranging in line. The starch grain and calcium oxalate cluster crystals distributed in the phloem parenchymas, and mucilage cells scattered in the cortex of the stem. There were 8 vascular bundles in the vein of leaves. This study provides a scientific basis for the identification and utilizing of Tetrastigma planicaule.


Zhang K.,Guangxi Institute for Food and Drug Control | Liang F.,Guangxi Asean Center for Food and Drug Safety Control | Deng M.,Guangxi Institute for Food and Drug Control | Liu X.,Guangxi Institute for Food and Drug Control | And 2 more authors.
Chinese Journal of Chromatography (Se Pu) | Year: 2016

A liquid chromatography-tandem mass spectrometric method with modified QuEChERS procedure for sample preparation was developed for the simultaneous determination of 7 classes of 35 veterinary drugs including sulfonamides, sulfonamide potentiators, beta-agonists, tetracyclines, amnatadine and sex hormones in porcine muscle. The drugs were extracted with 0.1 mol/L Na2EDTA (ethylene diamine tetraacetic acid)-Mcllvaine buffer solution and acetonitrile containing 2.5% (v/v) acetic acid, and then the extracts were purified using dispersive-solid phase extraction with NH2 sorbent, and finally analyzed by liquid chromatography-tandem mass spectrometry in multiple reaction monitoring mode via positive electrospray ionization. The correlation coefficients of the standard calibration curves for the 35 veterinary drugs were all above 0.996. The blank samples were spiked at three levels, and the average recoveries ranged from 71.8% to 113.5% with the relative standard deviations from 0.6% to 9.8% (n=6). The limits of detection and the limits of quantification were 0.01-1.01 μg/kg and 0.04-3.37 μg/kg respectively. The method developed is easy to operate, sensitive, with good purification effect and suitable for the determination of residues in porcine muscle.


Armani A.,University of Pisa | D'Amico P.,University of Pisa | Castigliego L.,University of Pisa | Sheng G.,Guangxi Institute for Food and Drug Control | And 2 more authors.
Food Control | Year: 2012

The jellyfish is a popular seafood in South-East Asia. It can also be found throughout Europe in many Chinese shops, which despite being well-organized from a commercial perspective, often disregard rules on product traceability. Therefore because jellyfish has still not been officially defined by the European Legislation on Food Hygiene, we performed a survey on fifty-six jellyfish products sold on the Italian market. This was done by assessing label compliance with European law and with the new Chinese Food Safety Law of 2009. Our survey found many incongruences and shortfalls including the presence of a trade name referring to vegetables or a lack of an unequivocal specification of ingredients. Focus is therefore needed on the possible hazards associated with the consumption of jellyfish products. In addition, regulations need adjusting in order to create more transparent marketing and sales practices. © 2012 Elsevier Ltd.


D'Amico P.,University of Pisa | Armani A.,University of Pisa | Castigliego L.,University of Pisa | Sheng G.,Guangxi Institute for Food and Drug Control | And 2 more authors.
Food Control | Year: 2013

Over the years, the European Union has developed a comprehensive legal framework to ensure seafood traceability. In fact, in this sector, where the complexity of the marketing patterns has reduced the efficiency of controls, frauds are becoming widespread. Moreover, the rapid growth of Chinese communities has led to an increase of importations from Asia, which sometimes do not fully respect rules on traceability. In this study, we performed a survey on seafood products collected from the market of the Chinese community of Prato (Italy), to assess the frequencies and types of non-compliance in the light of the requirements established by the European traceability legislation on fisheries and aquaculture. Examination of labels and contents of Chinese seafood products imported to Italy found that 83% did not meet EU requirements for traceability.Overall, this survey put into light the difficulties of the ethnic communities to conform to the European rules, the need to adapt the control system to the fast developing trade reality at all levels of the chain and the advisability to create standards that could be adopted worldwide. © 2013 Elsevier Ltd.


Feng F.,Guangxi Institute for Food and Drug Control | Wang H.-Y.,Shenyang Pharmaceutical University | Yang X.-C.,Shenyang Pharmaceutical University | Xing D.-X.,Shenyang Pharmaceutical University | And 4 more authors.
Chinese Journal of New Drugs | Year: 2016

Objective:To investigate the freeze-drying process of furanodiene-loaded nanostructured lipid carriers (FN-NLC) for injection. Methods:The optimum prescription and technique for freeze-dried FN-NLC were established by single factor experiments and the properties of the product were evaluated. Results:The optimal freeze-drying technology was determined with 5% trehalose solution as protective agent. No significant changes were found in the post- and pre-freeze-drying mean particle size, Zeta potential, and EE%, which were 105.57 nm versus 95.23 nm, -18.8 mV versus -19.6 mV, and 88.83% versus 91.27%, respectively. Conclusion:Stable freeze-dried preparation of FN-NLC can be prepared under the optimal condition established in this study. © 2016, Chinese Journal of New Drugs Co. Ltd. All right reserved.


Yan Y.,Guangxi Institute for Food and Drug Control | Zhang Y.-Y.,Guangxi Institute of Traditional Medical and Pharmaceutical science
Chinese Journal of New Drugs | Year: 2016

Objective:To establish a method for determining multielement in Traditional Chinese Medicine injections. Methods:After microwave digestion, 35 kinds of trace elements in the samples were determined by inductively coupled plasma mass spectrometry(ICP-MS), and the methodology was validated. Results:The calibration curves for the 35 kinds of trace elements all had good linearity, with r≥0.999 0. The limits of detections were in the range of 0.004 to 3.972 μg·L-1. The recoveries of the trace elements were between 84.35% and 107.56% with RSDs below 5%. Conclusion: This method is simple, sensitive, and precise, and can satisfy the requirement for multielement determination in traditional Chinese medicine injections. © 2016, Chinese Journal of New Drugs Co. Ltd. All right reserved.


Jiang S.-J.,Guangxi Institute for Food and Drug Control | Zhu B.,Guangxi Institute for Food and Drug Control | Zhou D.-D.,Shanghai University of Traditional Chinese Medicine | Wang G.-L.,Chinese National Institute for the Control of Pharmaceutical and Biological Products | And 2 more authors.
Journal of Medicinal Plants Research | Year: 2011

To establish an high-performance liquid chromatography-diode array detection (HPLC-DAD) method for the first time to simultaneously determine five major bioactive depsides, salianic acid A, protocatechuic acid, protocatechuic aldehyde, salvianolic acid G and salvianolic acid D in freeze-dried Dan-Shen injection. Chromatographic separation was carried out on a Phenomenex Hydro-C18 reserved-phase column (4.6×250 mm, 4 μm) by stepwise gradient elution with acetonitrile and water (0.1% trifluoroacetic acid, v/v) as the mobile phase. The UV detection wavelength was set at 281 nm for salianic acid A and protocatechuic aldehyde, 260 nm for protocatechuic acid, 228 nm for salvianolic acid G and 322 nm for salvianolic acid D, respectively. Good linear relationships were observed between peak areas and concentrations with r 2 values above 0.9997 for all the analytes. Average recoveries for the five major actives ranged from 98.3 to 99.4%. This method was rapid, sensitive, accurate, and could be readily applied to the quality assessment of freeze-dried Dan-Shen injection. © 2011 Academic Journals.


Mao X.-L.,Guangxi Academy of science | Mao X.-L.,Guangxi Liuzhou Peoples Hospital | Qin Y.,Guangxi Liuzhou Peoples Hospital | Cai J.,Guangxi Academy of science | And 5 more authors.
Hongwai Yu Haomibo Xuebao/Journal of Infrared and Millimeter Waves | Year: 2013

Mathematical expression was established for evaluating anticancer efficacy of samples of Z. nitidum to human tumor cells based on their infrared fingerprints. Chloroform extracts of the root of Z. nitidum from different habitats in China were used as subject samples to do anticancer experiments on two strains of human tumor cells, 7901 and Hela cells. Meanwhile, their fingerprints of infrared spectra were obtained. Screening arguments of backward elimination method was adopted to establish the spectra-effect correlation between infrared fingerprint and pharmacology data. The results showed that deviations of the predictive values from the true values were within ±10% for the two kinds of tumor cells, suggested that there was close correlation between infrared fingerprint and biological activity of Z. nitidum. The model implied that alkaloids in Z. nitidum have main effect on tumor cells.


Song N.,Guangxi Institute for Food and Drug Control | Zhang K.,Guangxi Institute for Food and Drug Control | Liu X.,Guangxi Institute for Food and Drug Control | Sang T.,Guangxi Institute for Food and Drug Control | And 2 more authors.
Chinese Journal of Chromatography (Se Pu) | Year: 2015

An ultra high performance liquid chromatography-tandem mass spectrometry method with modified QuEChERS procedure for sample preparation was developed for the simultaneous determination of 12 chemical drugs (chlorpheniramine, piroxicam, α-asarone etc) illegally added in herbal tea. The samples were extracted with acetonitrile, purified with QuEChERS procedure and filtrated by 0.22 μm microporous filters. The separation was carried on an XBridge BEH C18 column (100 mm×2. 1 mm, 3. 5 μm) by a gradient elution using acetonitrile/ 0. 1% (v/v) formic acid aqueous solution as mobile phases. The analytes were detected by tandem mass spectrometry with positive electrospray ionization (ESI+) in multiple reaction monitoring (MRM) mode, and quantified by external standard calibration method. The correlation coefficients of the standard calibration curves for the 12 analytes were all above 0. 997. The limits of detection ranged from 0. 1 μg/L to 2. 1 μg/L, and the limits of quantification ranged from 0. 4 μg/L to 8. 0 μg/L. The average recoveries of the 12 analytes spiked at three levels in blank samples ranged from 62. 7% to 95. 2% with the RSDs from 1. 3% to 10. 8%. The samples bought from markets were screened, and some of the samples showed positive for these analytes. The method developed is easy to operate, sensitive, and with good purification effect. It can be applied to the rapid determination of the 12 chemical drugs illegally added in herbal tea.


PubMed | Guangxi University and Guangxi Institute for Food and Drug Control
Type: Journal Article | Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2014

To study the macroscopic and microscopic characteristics of Zhuang medicine Tetrastigma planicaule.Macroscopic and microscopic identification were studied.The microscopic characteristics were significant. The root had more than 10 layers of cork cells arranging in line. The starch grain and calcium oxalate cluster crystals distributed in the phloem parenchymas, and mucilage cells scattered in the cortex of the stem. There were 8 vascular bundles in the vein of leaves.This study provides a scientific basis for the identification and utilizing of Tetrastigma planicaule.

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