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Zhao Q.,Huazhong University of Science and Technology | Liang Z.,Guangdong Women and Children Health Hospital | Tao S.,Guangdong Women and Children Health Hospital | Zhu J.,Guangdong Women and Children Health Hospital | Du Y.,Huazhong University of Science and Technology
Environmental Health: A Global Access Science Source | Year: 2011

Background. Over the last decade, a few studies have investigated the possible adverse effects of ambient air pollution on preterm birth. However, the correlation between them still remains unclear, due to insufficient evidences. Methods. The correlation between air pollution and preterm birth in Guangzhou city was examined by using the Generalized Additive Model (GAM) extended Poisson regression model in which we controlled the confounding factors such as meteorological factors, time trends, weather and day of the week (DOW). We also adjusted the co linearity of air pollutants by using Principal Component Analysis. The meteorological data and air pollution data were obtained from the Meteorological Bureau and the Environmental Monitoring Centre, while the medical records of newborns were collected from the perinatal health database of all obstetric institutions in Guangzhou, China in 2007. Results. In 2007, the average daily concentrations of NO2, PM10and SO 2in Guangzhou, were 61.04, 82.51 and 51.67 g/m3 respectively, where each day an average of 21.47 preterm babies were delivered. Pearson correlation analysis suggested a negative correlation between the concentrations of NO2, PM10, SO2,and temperature as well as relative humidity. As for the time-series GAM analysis, the results of single air pollutant model suggested that the cumulative effects of NO2, PM10and SO2reached its peak on day 3, day 4 and day 3 respectively. An increase of 100 g/m3 of air pollutants corresponded to relative risks (RRs) of 1.0542 (95%CI: 1.0080 ∼1.1003), 1.0688 (95%CI: 1.0074 ∼1.1301) and 1.1298 (95%CI: 1.0480 ∼1.2116) respectively. After adjusting co linearity by using the Principal Component Analysis, the GAM model of the three air pollutants suggested that an increase of 100 g/m3 of air pollutants corresponded to RRs of 1.0185 (95%CI: 1.0056∼1.0313), 1.0215 (95%CI: 1.0066 ∼1.0365) and 1.0326 (95%CI: 1.0101 ∼1.0552) on day 0; and RRs of the three air pollutants, at their strongest cumulative effects, were 1.0219 (95%CI: 1.0053∼1.0386), 1.0274 (95%CI: 1.0066∼1.0482) and 1.0388 (95%CI: 1.0096 ∼1.0681) respectively. Conclusions. This study indicates that the daily concentrations of air pollutants such as NO2, PM10and SO2have a positive correlation with the preterm births in Guangzhou, China. © 2011 Zhao et al; licensee BioMed Central Ltd. Source


Lin H.,Guangdong Provincial Institute of Public Health | Liang Z.,Guangdong Women and Children Health Hospital | Liu T.,Guangdong Provincial Institute of Public Health | Di Q.,Harvard University | And 7 more authors.
Atmospheric Environment | Year: 2015

A few studies have linked ambient air pollution with sex ratio at birth. Most of these studies examined the long-term effects using spatial or temporal comparison approaches. This study aimed to investigate whether parental exposure to air pollution before conception date could affect the likelihood of the offspring being male or female. We used the information collected in a major maternal hospital in Guangzhou, China. The parental exposure to air pollution was assessed using the air pollution concentration before the conception date. Logistic regression models were used to assess the association between air pollution exposure and birth sex with adjustment for potential confounding factors, such as maternal age, parental education levels, long-term trend, season, and weather condition (mean temperature and relative humidity). The analysis revealed that higher air pollution was associated with higher probability of female newborns, with the effective exposure around one week prior to conception date. In the one-pollutant models, PM10, SO2 and NO2 had significant effects. For example, the excess risk was 0.61% (95% confidence interval (95% CI): 0.36%, 0.86%) for a 10 ug/m3 increase in lag 2 day's PM10, 0.42% (95% CI: 0.21%, 0.64%) for lag 3 day's SO2 and 0.97% (95% CI: 0.44%, 1.50%) for lag 3 day's NO2; and in two-pollutant models, PM10 remained statistically significant. These results suggest that parental exposure to ambient air pollution a few days prior to conception might be a contributing factor to higher probability of giving birth to female offspring in Guangzhou. © 2015 Elsevier Ltd. Source


Xu J.,Guangdong Women and Children Health Hospital | Zhu C.-X.,Guangdong Women and Children Health Hospital | Chen Z.-Y.,Guangdong Women and Children Health Hospital | Lian Z.-Q.,Guangdong Women and Children Health Hospital | And 5 more authors.
Chinese Journal of Cancer Prevention and Treatment | Year: 2013

OBJECTIVE: To study the related clinical and pathologic factors of local recurrence after conserving therapy in early-stage breast cancer. METHODS: From September 1st, 1998 to July 31st, 2011, 146 patients with clinical Stage 0-II breast cancer who received breast conserving therapies(BCT) were analyzed retrospectively. Risk factors such as age, primary tumor size, axillary lymph node metastasis, estrogen receptor (ER) expression, progesterone receptor (PR) expression, human epidermal growth factor 2 (HER-2) expression and molecular subtypes associated with local recurrence were analyzed using Cox regression model. RESULTS: With a median follow-up of 61 months, ipsilateral local recurrences were detected as the first site of recurrence in 9 patients. Accumulated 3-year and 5-year local recurrence rate after BCT were 6.3% and 7.5%. Those factors including age, tumor size, ER/PR expressions and molecular subtypes had no dominal statistical differences for local recurrence (P>0.05). HER-2 positive status (P=0.002 1) and positive lymph node metastasis (P=0.03) were high risk factors and also independent factors for local recurrence. CONCLUSION: HER-2 positive status and positive lymph node metastasis are independent prognostic high risk factors for local recurrence after BCT, whereas no significant differences are observed in different age, tumor size and ER/PR expressions for local recurrence. Source

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