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Xie Z.-L.,Sun Yat Sen University | Li H.-J.,Sun Yat Sen University | Wang L.-Y.,Guangdong Pharmaceutical University | Liang W.-L.,Sun Yat Sen University | And 4 more authors.
Natural Product Communications | Year: 2013

Trichodermaerin (1), a novel diterpenoid lactone, together with the known compound, harziandione (2) were isolated from the culture broth of the fungus Trichoderma erinaceum associated with the sea star Acanthaster planci. Their structures were determined by analysis of the NMR and MS data. 1 was the Baeyer-Villiger monooxygenase catalyzed oxidation product of 2. Compound 2 did not show cytotoxic activities against various cancer cell lines. Source


Zhao Y.,Sun Yat Sen University | Li S.-Q.,Sun Yat Sen University | Li H.-J.,Sun Yat Sen University | Lan W.-J.,Sun Yat Sen University | Lan W.-J.,Guangdong Technology Research Center for Advanced Chinese Medicine
Chemistry of Natural Compounds | Year: 2013

Under chemical prescreening by direct infusion electrospray ionization mass spectrometry, three new lanostane triterpenoids, 3β-acetoxy-15α- hydroxylanosta-8,24-dien-21-oic acid (1), 1β,3β-dihydroxylanosta-8,24- dien-21-oic acid (2), and 15α-hydroxy-3-oxolanosta-8,24-dien-21-oic acid (3), together with two known lanostane triterpenoids, 3β,15α- dihydroxylanosta-8,24-dien-21-oic acid (4) and 3β-hydroxylanosta-8,24-dien- 21-oic acid (5), were isolated from the marine fungus Ceriporia lacerate derived from Acanthaster planci. Their structures were established by MS and 1D and 2D NMR spectroscopic techniques. © 2013 Springer Science+Business Media New York. Source


Liu W.,Sun Yat Sen University | Liu W.,Guangdong Pharmaceutical University | Li H.-J.,Sun Yat Sen University | Xu M.-Y.,Sun Yat Sen University | And 7 more authors.
Organic Letters | Year: 2015

Pseudellones A and B (1 and 2), a pair of irregularly bridged epimonothiodiketopiperazine diastereomers constructed from unusual 3-indolylglycine and alanine residues, and an alkaloid pseudellone C (3) possessing a unique skeleton were isolated from the marine-derived fungus Pseudallescheria ellipsoidea F42-3. Their structures were determined by spectroscopic data, ECD calculation, and X-ray single crystal diffraction. The biogenetic pathways of 1-3 were proposed, and 1H-indole-3-carboxylic acid (4), a plausible biosynthetic intermediate, was coisolated. © 2015 American Chemical Society. Source


Leung D.,Sun Yat Sen University | Yang D.,Sun Yat Sen University | Yang D.,Guangdong Technology Research Center for Advanced Chinese Medicine | Li Z.,Sun Yat Sen University | And 4 more authors.
Industrial and Engineering Chemistry Research | Year: 2012

The advancement of biodiesel production emphasizes the finding of new, low-cost, and plentiful raw materials. Insects, as one of the most plentiful biological resources worldwide, could be potential candidates for biodiesel production. In this study, Zophobas morio (Coleoptera: Tenebrionidae) was evaluated as an insect feedstock, attempting to prove the feasibility of producing qualified biodiesel. The oil content in dried Z. morio larvae was found to be 33.80 wt %. Biodiesel from Z. morio larva oil was prepared by acid esterification followed by alkaline transesterification. The parameters of the reaction were optimized at 1.25 wt % potassium hydroxide catalyst, a 5:1 methanol to oil ratio, a reaction temperature of 50 °C, and a reaction time of 45 min. Under these conditions, the maximum fatty acid methyl ester yield was 92.35 wt %. The biodiesel obtained was verified to be in compliance with the ASTM D6751 standard. This study supports the use of Z. morio larva oil as a viable and valuable raw feedstock for biodiesel production and indicates the potential use of insects as feedstock for applications in energy production. © 2011 American Chemical Society. Source


Lan W.-J.,Sun Yat Sen University | Lan W.-J.,Guangdong Technology Research Center for Advanced Chinese Medicine | Liu W.,Sun Yat Sen University | Liu W.,Guangdong Pharmaceutical University | And 9 more authors.
Marine Drugs | Year: 2014

Two novel isobenzofuranone derivatives, pseudaboydins A ( 1) and B ( 2), along with five known compounds, including ( R)-2-(2-hydroxypropan-2-yl)-2,3- dihydro-5-hydroxybenzofuran (3), (R)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-5- methoxybenzofuran (4), 3,3′-dihydroxy-5,5′-dimethyldiphenyl ether (5), 3-(3-methoxy-5-methylphenoxy)-5-methylphenol (6) and (-)-regiolone (7), were isolated from the culture broth of the marine fungus, Pseudallescheria boydii, associated with the starfish, Acanthaster planci. Their structures were elucidated primarily based on NMR and MS data. The absolute configurations of 1-4 were determined by CD spectroscopy and single-crystal X-ray diffraction studies. The cytotoxic and antibacterial activities of 1-4 were evaluated. Pseudaboydin A (1) showed moderate cytotoxic activity against human nasopharyngeal carcinoma cell line HONE1, human nasopharyngeal carcinoma cell line SUNE1 and human glandular lung cancer cell line GLC82 with IC50 values of 37.1, 46.5 and 87.2 μM, respectively. © 2014 by the authors; licensee MDPI. Source

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