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Zhang N.-H.,Guangdong Second Provincial Traditional Chinese Medicine Hospital | Zhang N.-H.,Sun Yat Sen University | Peng R.-Q.,Sun Yat Sen University | Ding Y.,Sun Yat Sen University | Zhang X.-S.,Sun Yat Sen University
Oncology Reports | Year: 2016

The adenovirus vector-based cancer gene therapy is controversial. Low transduction efficacy is believed to be one of the main barriers for the decreased expression of coxsackie and adenovirus receptor (CAR) on tumor cells. However, the expression of CAR on primary tumor tissue and tumor tissue survived from treatment has still been not extensively studied. The present study analyzed the adenovirus infection rates and CAR expression in human lung adenocarcinoma cell line A549 and its cisplatin-resistant subline A549/DDP. The results showed that although the CAR expression in A549 and A549/DDP was not different, compared with the A549, A549/DDP appeared obviously to reject adenovirus infection. Moreover, we modified CAR expression in the two cell lines with proteasome inhibitor MG-132 and histone deacetylase inhibitor trichostatin A (TSA), and analyzed the adenovirus infection rates after modifying agent treatments. Both TSA and MG-132 pretreatments could increase the CAR expression in the two cell lines, but the drug pretreatments could only make A549 cells more susceptible to adenovirus infectivity. Source


Guo H.,Guangdong Second Provincial Traditional Chinese Medicine Hospital | Liu M.-Q.,Guangzhou University of Chinese Medicine
Chinese Medical Journal | Year: 2013

Objective To review the major progress in mechanism of traditional Chinese medicine (TCM) in the treatment of allergic rhinitis (AR). Methods Contents about the treatment mechanism of TCM in the therapy of AR in this article were obtained from 22 original articles and reviews published in Chinese- and English-language journals. All of the references were searched by use of Pubmed (1997-2012). Results AR is one of the most common and most serious public health problems in children and young people. Many AR patients were worried about the possible adverse effects of synthetic drugs they were taking. Thus, they seek complementary and alternative therapy, such as TCM. TCM emphasized on the importance of holistic convalescence, not just the disease itself. The favorable safety profile of TCM makes well-acceptance by the general population. In the recent decade, more and more studies of TCM for AR are developed. These studies indicated that the treatment of allergic disorders with TCM therapy including herbal medicines and acupuncture are of safety and efficacy. The mechanism of TCM in the treatment of AR has been discussed. It has been reported that a number of the herbs in the Chinese herbal formulae used in the treatment possess anti-allergic, anti-inflammatory or immune modulation activity. Such function include the inhibition of the release or the activity of mast cell mediators (such as histamine), inhibition the induction of inflammation reaction by chemical agents, and down regulation of serum (immunoglobulin E) IgE levels or the activity of lymphocyte and/or macrophage. Conclusions TCM are frequently used concurrently to improve the clinical efficacy. This review is focuses on the description of the actions mechanism of Chinese medicine's approach relevant to the treatment of AR. Source


Chen X.-L.,Guangzhou University | Xu K.,Guangdong Second Provincial Traditional Chinese Medicine Hospital | Luo R.-H.,Guangdong Second Provincial Traditional Chinese Medicine Hospital | Lin M.-J.,Guangdong Second Provincial Traditional Chinese Medicine Hospital
Journal of Acupuncture and Tuina Science | Year: 2013

Objective: To observe the clinical efficacy of electroacupuncture in treating depression. Methods: By a randomized controlled study method, sixty patients with depression were randomized into an electroacupuncture group and a medication group, 30 in each. The electroacupuncture group was treated with electroacupuncture, and the medication group was orally administrated Paroxetine tablets. They were evaluated by using Hamilton Depression Scale (HAMD) before and after treatments and the safety was also assessed. Results: The total effective rate was 83. 3% in the electroacupuncture group versus 60. 0% in the medication group, and the difference was statistically significant (P<0. 05). The electroacupuncture group was superior to the medication group in comparing the improvement of HAMD scores after treatment (P<0. 05). Conclusion: Electroacupuncture is an effective approach in treating depression. © 2013 Shanghai Research Institute of Acupuncture and Meridian and Springer-Verlag Berlin Heidelberg. Source


Chen X.-L.,Guangzhou University | Xu K.,Guangdong Second Provincial Traditional Chinese Medicine Hospital | Qin X.-H.,Guangdong Second Provincial Traditional Chinese Medicine Hospital
Journal of Acupuncture and Tuina Science | Year: 2013

Objective: To observe the clinical efficacy of electroacupuncture in treating perimenopausal insomnia. Methods: Seventy eligible subjects were randomized into two groups, 38 subjects in the treatment group were intervened by electroacupuncture, 30 min each session; 32 subjects in the control group were intervened by Alprazolam, 0.4 mg each time before sleep. Athens insomnia scale (AIS) was adopted to evaluate sleep quality. Results: The therapeutic efficacy in the treatment group was significantly better than that in the control group (P<0.05). Conclusion: Electroacupuncture can produce a content therapeutic efficacy in treating perimenopausal insomnia. © 2013 Shanghai Research Institute of Acupuncture and Meridian and Springer-Verlag Berlin Heidelberg. Source


Lu H.,Southern Medical University | Jiang J.,Southern Medical University | Xie G.,Guangdong Second Provincial Traditional Chinese Medicine Hospital | Liu W.,Guangdong Second Provincial Traditional Chinese Medicine Hospital | Yan G.,Guangzhou Medical College
Experimental and Therapeutic Medicine | Year: 2013

Osteoarthritis is a common chronic and progressively degenerative joint condition. The stem bark of Eucommia ulmoides Oliver (a member of the Eucommiaceae family), which is also known as Du-Zhong, is a traditional Chinese medicine commonly used for the treatment of rheumatoid arthritis. However, the mechanisms underlying the effects of Eucommia in the treatment of arthritis of the knee require further study. The present study investigated the effects of an aqueous extract of Eucommia on the articular cartilage (by Mankin's grade) and the levels of matrix metalloproteinase-1 (MMP-1), MMP-3 and MMP-13 in the serum and synovial fluid in a rat model of osteoarthritis. The serum levels of MMP-1, -3 and -13 were measured by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) at weeks 1, 2 and 4. The levels of MMP-1, -3 and 13 were signifcantly decreased in the rats treated with Eucommia compared with those in the control rats (P<0.05). Histopathological examination results indicated a lower Mankin's grade in the Eucommia group compared with that of the control rats. Therefore, Eucommia was demonstrated to have a cartilage-protecting effect in rats with osteoarthritis, potentially by improving cartilage metabolism, regulating the degradation of the extracellular matrix of the articular cartilage, and inhibiting apoptosis in chondrocytes, thereby slowing down joint degeneration. Source

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