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Wu H.,Chinese National Institute for Communicable Disease Control and Prevention | Wang H.,Shandong University | Wang Q.,Shandong University | Xin Q.,Shandong Academy of Occupational Health and Occupational Medicine | Lin H.,Guangdong Provincial Institute of Public Health
Global health action | Year: 2014

Background : Hand, foot, and mouth disease (HFMD) is a contagious viral illness that commonly affects infants and children. This infection is an emerging infectious disease in Rizhao in recent years. The present study examined the short-term effects of meteorological factors on adolescent HFMD in Rizhao. Design : A generalized additive Poisson model was applied to estimate the effects of meteorological factors on adolescent HFMD occurrence in 2010-2012. Subgroup analyses were also conducted to examine the potential effect modifiers of the association in terms of age, sex, and occupation. Results : A positive effect of temperature was observed (ER [excess risk]=1.93%, 95% CI: 1.05 to 2.82% for 1°C increase on lag 5 day). A negative effect of relative humidity at lag 1 day and positive effects were found on lag 5-7 days, and an adverse effect was observed for sunshine at lag days 3-4 (ER=-0.71%, 95% CI: -1.25 to -0.17% on lag day 4). We also found that age, sex, and occupation might be important effect modifiers of the effects of weather variables on HFMD. Conclusions : This study suggests that meteorological factors might be an important predictor of adolescent HFMD occurrence in Rizhao. Age, sex, and occupation might be important effect modifiers of the effects. Source


Tian L.,Chinese University of Hong Kong | Qiu H.,Chinese University of Hong Kong | Pun V.C.,Chinese University of Hong Kong | Lin H.,Guangdong Provincial Institute of Public Health | And 4 more authors.
American Journal of Respiratory and Critical Care Medicine | Year: 2013

Rationale: Recent experimental and clinical studies suggest that exogenous carbon monoxide (CO) at lower concentrations may have beneficial effects under certain circumstances, whereas populationbased epidemiologic studies of environmentally relevant CO exposure generated mixed findings. Objectives: To examine the acute effects of ambient CO on respiratory tract infection (RTI) hospitalizations. Methods: A time series study was conducted. Daily emergency hospital admission and air pollution data in Hong Kong were collected from January 2001 to December 2007. Log-linear Poisson models wereused to estimate the associations between daily hospital admissions for RTI and daily average concentrations of CO across three background air monitoring stations and three roadside stations, respectively, controlling for other traffic-related copollutants. Measurements and Main Results: CO concentrations were low during the study period with a daily average of 0.6 ppm in background stations and 1.0 ppm in roadside stations. Negative associations were found between ambient CO concentrations and daily hospital admissions for RTI. One ppm increase in background CO at lag 0-2 days was associated with 25.7% (95% confidence interval, 29.2 to 22.1) change in RTI admissions from the whole population according to single-pollutant model; the negative association became stronger when nitrogen dioxide or particulate matter with aerodynamic diameter less than 10 mm was adjusted for in two-pollutant models.Thenegative associationseemedtobestronger in the adults than in the children and elderly. Conclusions: Short-termexposure to ambientCOwas associated with decreased risk of hospital admissions for RTI, suggesting some acute protective effectsof lowambientCOexposureonrespiratory infection. Copyright © 2013 by the American Thoracic Society. Source


Liu Y.,U.S. Center for Disease Control and Prevention | Lin H.,Guangdong Provincial Institute of Public Health | Zhu Q.,U.S. Center for Disease Control and Prevention | Wu C.,U.S. Center for Disease Control and Prevention | And 2 more authors.
Vaccine | Year: 2014

We reviewed the adverse events following immunization of live attenuated Japanese encephalitis vaccine in Guangdong Province, China. During the period of 2005-2012, 23 million doses of live attenuated Japanese encephalitis vaccine were used and 1426 adverse events were reported (61.24 per million doses); of which, 570 (40%) were classified as allergic reactions (24.48 per million doses), 31 (2%) were neurologic events (1.33 per million doses), and 36 (2.5%) were diagnosed as serious adverse events (1.55 per million doses). This study suggests that the JEV-L has a reasonable safety profile, most adverse events are relatively mild, with relatively rare neurologic events being observed. © 2014 Elsevier Ltd. Source


Lin H.L.,Guangdong Provincial Institute of Public Health | Lin H.L.,U.S. Center for Disease Control and Prevention | An Q.Z.,Fudan University | Wang Q.Z.,Shandong University | Liu C.X.,Shenzhen Entry Exit Inspection and Quarantine Bureau
Public Health | Year: 2013

Objective: Inconsistent findings of association between supplemental folate consumption and pancreatic cancer risk have been observed in the literature. This study aims to summarize the relationship between folate intake and risk of pancreatic cancer. Study design: Pertinent studies published before November 2011 were identified by searching PubMed and Embase and by reviewing the reference lists of retrieved articles. The summary relative risks were estimated by the random effects model. A linear regression analysis of the natural logarithm of the relative risk (RR) was carried out to assess a possible dose-response relationship between folate intake and pancreatic cancer risk. Results: Ten studies on dietary and supplemental folate intake and pancreatic cancer (4 case-control and 6 cohort studies) were included in the meta-analysis. The pooled RRs of pancreatic cancer for the highest vs lowest categories of dietary folate intake and supplemental folate intake were 0.66 (95% CI: 0.49-0.88) and 1.08 (95% CI, 0.82-1.41), respectively. The dose-response meta-analysis indicated that a 100μg/day increment in dietary folate intake conferred a RR of 0.93 (95% CI: 0.90-0.97). These findings support the hypothesis that dietary folate may play a protective role in carcinogenesis of pancreatic cancer. © 2013 The Royal Society for Public Health. Source


Chan J.Y.C.,Chinese University of Hong Kong | Lin H.L.,Guangdong Provincial Institute of Public Health | Lin H.L.,U.S. Center for Disease Control and Prevention | Tian L.W.,Chinese University of Hong Kong
Epidemiology and Infection | Year: 2014

Varicella accounts for substantial morbidities and remains a public health issue worldwide, especially in children. Little is known about the effect of meteorological variables on varicella infection risk for children. This study described the epidemiology of paediatric varicella notifications in Hong Kong from 2004 to 2010, and explored the association between paediatric varicella notifications in children aged <18 years and various meteorological factors using a time-stratified case-crossover model, with adjustment of potential confounding factors. The analysis found that daily mean temperature, atmospheric pressure and Southern Oscillation Index (SOI) were positively associated with paediatric varicella notifications. We found that an interquartile range (IQR) increase in temperature (8·38°C) at lag 1 day, a 9·50 hPa increase in atmospheric pressure for the current day, and a 21·91 unit increase in SOI for the current day may lead to an increase in daily cases of 5·19% [95% confidence interval (CI) 1·90-8·58], 5·77% (95% CI 3·01-8·61), and 4·32% (95% CI 2·98-5·68), respectively. An IQR increase in daily relative humidity (by 11·96%) was associated with a decrease in daily paediatric varicella (-2·79%, 95% CI -3·84 to -1·73). These findings suggest that meteorological factors might be important predictors of paediatric varicella infection in Hong Kong. Copyright © Cambridge University Press 2013. Source

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