Wang M.,Guangdong No2 Provincial People Hospital |
Wang J.,Guangdong No2 Provincial People Hospital |
Deng J.,Guangdong No2 Provincial People Hospital |
Li X.,Guangdong No2 Provincial People Hospital |
And 2 more authors.
Medical Oncology | Year: 2015
MiR-145 has been reported to be downregulated in multiple tumors. It acts as a tumor suppressor in lung cancer. In this study, we investigated the potential effects of miR-145 on invasion and metastasis and the molecular mechanism in non-small cell lung cancer. MiR-145 was downregulated in the NSCLC specimens and significantly correlated with advanced clinical stage and lymph node metastasis. In addition, AEG-1/MTDH was a direct target of miR-145, and the expression of AEG-1/MTDH was inversely correlated with miR-145 expression in NSCLC tissues. Ectopic expression of miR-145 suppressed cell invasion and metastasis in NSCLC cells. AEG-1/MTDH overexpression partially reversed the suppressive effect of miR-145. These findings provide novel insights with potential therapeutic applications for the treatment of NSCLC. © 2014, Springer Science+Business Media New York.