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Chen L.,Nanjing Southeast University | Fan X.,Nanjing Southeast University | Qiu R.,Nanjing Southeast University | Jin G.,Nanjing Southeast University | And 4 more authors.
Science of Advanced Materials | Year: 2013

Detection of Bone Marrow Mesenchymal Stem Cells (BMSCs) in vivo by 7.0T Magnetic Resonance Imaging (MRI) was performed after stereotactic injection of SPIO-labeled BMSCs into a rat model with traumatic brain injury (TBI). It was demonstrated that noninvasive MRI tracing allowed dynamic monitoring of magnetically labeled BMSCs following transplantation and may be a good way to evaluate the capability of stem cells migration. © 2013 by American Scientific Publishers. Source


Wang S.,Xinxiang Medical University | Wang S.,Chinese Academy of Sciences | Wang S.,Harvard University | Wang S.,Guangdong Landau Biotechnology Co. | And 5 more authors.
PLoS ONE | Year: 2015

Melatonin plays a protective role in type 2 diabetes (T2D) through regulation of glucose metabolism. Whether transcutaneous vagus nerve stimulation (taVNS) is antidiabetic and whether a modulated melatonin production is involved in the antidiabetic mechanism of taVNS is unknown. In this study, once daily 30min noninvasive taVNS was administered in Zucker diabetic fatty (ZDF, fa/fa) and Zucker lean (ZL, +/fa) littermates under anesthesia for 5 consecutive weeks. The acute and chronic influences of taVNS on the secretion of melatonin were studied as well as the effects of taVNS on blood glucose metabolism. We found that naïve ZDF rats develop hyperglycemia naturally with age. Each taVNS session would trigger a tidal secretion of melatonin both during and after the taVNS procedure and induce an acute two-phase glycemic change, a steep increase followed by a gradual decrease. Once daily taVNS sessions eventually reduced the glucose concentration to a normal level in seven days and effectively maintained the normal glycemic and plasma glycosylated hemoglobin (HbAlc) levels when applied for five consecutive weeks. These beneficial effects of taVNS also exist in pinealectomized rats, which otherwise would show overt and continuous hyperglycemia, hyperinsulinemia, and high HbAlc levels. We concluded that multiple taVNS sessions are antidiabetic in T2D through triggering of tidal secretion of melatonin. This finding may have potential importance in developing new approaches to the treatment of T2D, which is highly prevalent, incurable with any current approaches, and very costly to the world. © 2015 Wang et al. Source


Wan Y.L.,Guangdong Landau Biotechnology Co.
Dong wu xue yan jiu = Zoological research / "Dong wu xue yan jiu" bian ji wei yuan hui bian ji | Year: 2011

To screen spontaneous diabetic mellitus and explore methods for its rapid identification, the basal and inferred levels of blood glucose of 440 overweight, middle- and old-aged cynomolgus monkeys were analyzed. Diagnostic diabetes was further validated by the oral glucose tolerance test (OGTT) and urine glucose. The average level of blood glucose of these cynomolgus monkeys was (3.88±0.98) mmol/L, which was lower than the level for suspected diabetes (5.0 mmol/L). Of them, 56 (12.72%) monkeys were identified with levels of blood glucose greater than 5.0 mmol/L and diagnosed as the diabetic subjects. This population showed impaired glucose tolerance using the OGTT and 39 of the 56 (69.23%) had glucose positive urine. The methods for screening diabetic mellitus used in this study were simple, quick, and limited the harm to animals. However, the incidence of diabetes was higher in these tested monkeys than in the regular human population in China (9.7%), suggesting that these methods are useful for screening diabetic disease in a large population but not suitable for all cynomolgus monkeys. Source


Chen L.,Nanjing Southeast University | Qiu R.,Nanjing Southeast University | Xu Q.,Guangdong Landau Biotechnology Co.
Journal of Nanoscience and Nanotechnology | Year: 2014

This paper reviews the recent studies and development of mesenchymal stem cell (MSCs) therapy for neurodegenerative diseases. MSCs transplantation, a promising therapy, can promote functional recovery by producing trophic factors that induce survival and regeneration of host neurons in animal models and patients with neurodegenerative diseases. In this review, we introduce briefly the potential benefits of MSCs. Finally, the possibility of clinical application in neurodegenerative diseases is also discussed. Copyright © 2014 American Scientific Publishers All rights reserved. Source


Chen L.,Nanjing Southeast University | Qiu R.,Nanjing Southeast University | Xu Q.,Guangdong Landau Biotechnology Co.
Journal of Nanoscience and Nanotechnology | Year: 2014

This paper reviews the recent studies and development of stem cell therapy for ischemic stroke. Stem cells can differentiate into several types of mature cells, including neurons and glial cells. Stem cell transplantation, a promising therapy, can be able to facilitate functional recovery both in animal models and stroke patients. In this review, we introduce briefly the different types of endogenous stem cells and the transplantation of exogenous stem cells; in addition, we discuss the timing, dosage, route, and tracing of stem cell therapy for ischemic stroke in details. Finally, the clinical challenge and application of stem cells in future are also discussed. Copyright © 2014 American Scientific Publishers All rights reserved. Source

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