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Wu T.-X.,Guangdong Medical College | Liao J.-M.,Guangdong Key Laboratory for Research and Development of Natural Drugs | Chen Y.,Guangdong Key Laboratory for Research and Development of Natural Drugs | Huang L.-F.,Guangdong Key Laboratory for Research and Development of Natural Drugs | Chen W.-S.,Guangdong Key Laboratory for Research and Development of Natural Drugs
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2010

BACKGROUND: Fluoride treatment of osteoporosis has been controversial. Literatures addressing the effect of fluoride on bone bio-mechanical parameters of femur in young rats are few. OBJECTIVE: To study the effects of fluoride on bone biomechanical parameters of femur in young rats. METHODS: Ninety 2-month-old SPF Sprague Dawley rats, half male and female, were randomly divided into 9 groups: control group (young, adult and long-time) and drug-administered group (young high-fluoride, young low-fluoride, adult high-fluoride, adult low-fluoride, long-term high-fluoride and long-term low-fluoride). Rats in the control group were orally administered with physiological saline, while in the drug-administered group were given orally with different dose fluoride at the corresponding times. After experiment, rats were sacrificed under anaesthesia. Three-point bending test was performed at the left femur. The effects of fluoride on maximum load and rigidity of femur were measured. RESULTS AND CONCLUSION: Compared with young control group, the maximum load and the rigidity of femur in the young high-fluoride group were decreased by 13.18% and 13.61%, respectively (P < 0.05), which had no dramatically difference in the young low-fluoride group. Compared with long-term high-fluoride group, the maximum load and the rigidity of femur in the young high-fluoride were decreased by 17.22% and 17.17% (P < 0.05), which were obvious increased in the long-term low-fluoride group by 18.33% and 19.15%, respectively (P < 0.05). The maximum load and the rigidity of femur were strengthened in the adult high-fluoride and adult low-fluoride groups (P < 0.05). The results suggested that young rats are more sensitive to high-dose fluoride, which can reduce bone quality in rats. The negative effects on bone quality of rats were gradually displayed as the prolongation of the period of fluoride.


Lin S.E.,Guangdong Medical College | Huang J.P.,Guangdong Medical College | Wu L.Z.,Guangdong Medical College | Wu T.,Guangdong Medical College | Cui L.,Guangdong Key Laboratory for Research and Development of Natural Drugs
Biomedical and Environmental Sciences | Year: 2013

Objective: To study whether effect of aspirin plus low-dose diethylstilbestrol is more effective and safer than high diethylstilbestrol dose alone on prevention of ovariectomy-induced osteopenia and dyslipidemia. Methods: Thirty-eight 4-month-old female SD rats were divided into baseline (BAS) group (n=6), sham operation group (n=8) and ovariectomy (OVX) group (n=24). The OVX group was further divided into vehicle treatment group (n=8), diethylstilbestrol (30 μg/kg-d) treatment group (OVX+D30 group, n=8), and aspirin (9 mg/kg-d) plus diethylstilbestrol (10 μg/kg-d) treatment group (OVX+A-D10 group, n=8). Their left tibiae were collected for the bone histomorphometric analysis in undecalcified sections. Left femurs were collected for the bone mineral density measurement. Results: The body weight and serum cholesterol were increased, while uterine weight and cancellous bone mass were decreased in OVX rats compared with the SHAM group. Cancellous bone mass was significantly increased, while body weight and bone resorption parameters were decreased in both A-D10 and D30 treatment group compared with OVX group. The rats treated with A-D10 showed significantly increased in bone formation parameters and decreased in serum triglyceride compared with the D30-treated rats. Conclusion: Aspirin plus low-dose diethylstilbestrol can effectively prevent osteopenia by reducing bone resorption, and is thus a better treatment modality for preventing dyslipidemia than high-dose diethylstilbestrol alone. Copyright © 2013 by China CDC.


Wang S.-Q.,Guangdong Medical College | Zhu Y.-Z.,Guangdong Key Laboratory for Research and Development of Natural Drugs | Ye H.,Guangdong Key Laboratory for Research and Development of Natural Drugs | Zheng X.-B.,Guangdong Key Laboratory for Research and Development of Natural Drugs
Chinese Traditional and Herbal Drugs | Year: 2013

The innovation of Chinese materia medica (CMM) is the central driver of CMM modernization. The application of modern theories and techniques in life sciences to innovating CMM research remains to be an urgent issue to be solved. Currently, the international R&D for drug is stepping into a new trend, in which these transformations are going through a signal target to multiple drug combination and active constituents selection by pharmacodynamics to optimize the design with pharmacokinetics. In the face of changes, the pace of CMM R&D is slow. Based on the R&D content of system biology and Huangqin Decoction extract (PHY906), the "preceded pharmacokinetics" concept is introduced. Taking pharmacokinetics as the tool to rapidly screen the potential constituents with the aims at CMM R&D. Furthermore, why the "preceded pharmacokinetics" is needed and how to start the innovation model are preliminarily discussed in this paper.

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