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Chi Y.,South China Normal University | Yue Z.,Sun Yat Sen University | Liu Y.,Guangdong Province Hospital of Traditional Chinese Medicine | Mo L.,South China Normal University | Chen Q.,South China Normal University
Human Brain Mapping | Year: 2014

There are ongoing debates on whether object concepts are coded as supramodal identity-based or modality-specific representations in the human brain. In this fMRI study, we adopted a cross-modal "prime-neutral cue-target" semantic priming paradigm, in which the prime-target relationship was manipulated along both the identity and the modality dimensions. The prime and the target could refer to either the same or different semantic identities, and could be delivered via either the same or different sensory modalities. By calculating the main effects and interactions of this 2 (identity cue validity: "Identity_Cued" vs. "Identity_Uncued") × 2 (modality cue validity: "Modality_Cued" vs. "Modality_Uncued") factorial design, we aimed at dissociating three neural networks involved in creating novel identity-specific representations independent of sensory modality, in creating modality-specific representations independent of semantic identity, and in evaluating changes of an object along both the identity and the modality dimensions, respectively. Our results suggested that bilateral lateral occipital cortex was involved in creating a new supramodal semantic representation irrespective of the input modality, left dorsal premotor cortex, and left intraparietal sulcus were involved in creating a new modality-specific representation irrespective of its semantic identity, and bilateral superior temporal sulcus was involved in creating a representation when the identity and modality properties were both cued or both uncued. In addition, right inferior frontal gyrus showed enhanced neural activity only when both the identity and the modality of the target were new, indicating its functional role in novelty detection. © 2014 Wiley Periodicals, Inc. Source

Liang B.,University of South China | Zhang D.,Guangdong Province Hospital of Traditional Chinese Medicine | Zhang D.,Guangzhou University of Chinese Medicine | Wen X.,University of South China | And 5 more authors.
Frontiers in Human Neuroscience | Year: 2014

Previous studies have demonstrated that the difference between resting-state brain activations depends on whether the subject was eyes open (EO) or eyes closed (EC). However, whether the spontaneous fluctuations are directly related to these two different resting states are still largely unclear. In the present study, we acquired resting-state functional magnetic resonance imaging data from 24 healthy subjects (11 males, 20.17 ± 2.74 years) under the EO and EC states. The amplitude of the spontaneous brain activity in low-frequency band was subsequently investigated by using the metric of fractional amplitude of low frequency fluctuation (fALFF) for each subject under each state. A support vector machine (SVM) analysis was then applied to evaluate whether the category of resting states could be determined from the brain spontaneous fluctuations. We demonstrated that these two resting states could be decoded from the identified pattern of brain spontaneous fluctuations, predominantly based on fALFF in the sensorimotor module. Specifically, we observed prominent relationships between increased fALFF for EC and decreased fALFF for EO in sensorimotor regions. Overall, the present results indicate that a SVM performs well in the discrimination between the brain spontaneous fluctuations of distinct resting states and provide new insight into the neural substrate of the resting states during EC and EO. © 2014 Liang, Zhang, Wen, Xu, Peng, Huang, Liu and Huang. Source

Zhou H.,Sun Yat Sen University | Zhou H.,Guangdong Medical College | Liu Z.,Sun Yat Sen University | Liu J.,Sun Yat Sen University | And 7 more authors.
American Journal of Neuroradiology | Year: 2011

BACKGROUND AND PURPOSE: Radiation-induced cognitive dysfunction is a common and serious complication after radiation therapy of brain tumor, yet knowledge of its mechanism is poorly understood. The aim of this study was to establish a young rat model for acute radiation encephalopathy, at both cognitive and pathologic levels, induced by fractionated irradiation. MATERIALS AND METHODS: Four-week-old male rats were randomized into sham (0 Gy) and 2 experimental groups receiving fractionated irradiation of 5 Gy/day, 5 days/week, with total doses of 20 and 40 Gy, respectively. Cognition, BBB integrity, and potential astrogliosis were evaluated at 0, 4, 8, and 12 weeks' postirradiation. RESULTS: Twenty-Gy irradiation led to transient cognitive impairment only at 4 weeks' postirradiation. Forty-Gy irradiation induced cognitive impairment at both 4 and 8 weeks' postirradiation, which was more severe than that induced by 20 Gy. Cognitive impairment was accompanied by a transient increase in BWC only at 4 weeks for the 40-Gy group. Disrupted BBB permeability was detected at 4 and 8 weeks' postirradiation for the 20-Gy group, and at 4, 8, and 12 weeks' postirradiation for 40-Gy group, respectively. Increased astrogliosis in the hippocampus could be detected at 4 weeks' postirradiation for 40-Gy group. CONCLUSIONS: Fractionated irradiation in this experiment could induce acute brain injury, leading to cognitive impairment in young rats. BBB disruption might be a sensitive index for acute radiation encephalopathy. In addition, reactive astrogliosis might play an important role in this process. The present model, especially the 40-Gy irradiation group, is useful for basic and therapeutic studies of acute radiation encephalopathy. Source

Yang Z.M.,Guangdong Province Hospital of Traditional Chinese Medicine
IET Conference Publications | Year: 2012

Objective: To study an effective solution for the information management and automatic statistical analysis of population of sub-health state. Method: a systematic analysis of business operations processes and modules division, designed to achieve system function analysis, database design, analysis, and network topology, through the actual use of specific investigations to verify the effectiveness and practicality of the system. Results: The system realizes some targets, which includes the survey data collection, storage, analysis, and network sharing, and also accesses to physical medicine, psychology, social coping, lifestyle, quality of life of the distribution to the sub-health status of those surveyed population, and achieves individual subjects personalized recommendations nursed back to health, and provides a basis and information platform for the sub-health state intervention. Conclusion: The system provides a good data management and analysis platform for sub-health population surveys, management and intervention. Source

Wang J.,Guangdong Province Hospital of Traditional Chinese Medicine | Shen Q.,Guangdong Province Hospital of Traditional Chinese Medicine
Medical Journal of Wuhan University | Year: 2011

Objective: To observe the changes of ovarian blood flow and function in patients with hysterectomy. Methods: The fasting blood samples of 30 cases of hysterectomy patients were collected respectively on cycle days 5-7 before operation and on the same cycle days 6 months after operation to determine the levels of follicle-stimulating hormone (FSH). Ovarian volume, numbers of antral follicles, ovarian stromal artery peak flow velocity, and resistance index (RI) were measured by transvaginal color Doppler ultrasound. The results were compared with those of 30 healthy women who underwent physical examination at same period. Results: The values of FSH, ovarian volume, ovarian stromal artery peak velocity and RI were not different between pre-hysterectomy group and normal controls (all P > 0.05). But after operation, the ovarian volume and numbers of antral follicles decreased, and RI of ovarian stromal artery increased significantly (all P < 0.05), while FSH levels and ovarian stromal artery peak velocity did not change (all P > 0.05). Conclusion: Hysterectomy has some impacts on ovarian blood flow and function, and postoperative follow-up is necessary for the patients. Source

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