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Deng C.-Y.,Guangdong Cardiovascular Institute and Guangdong Academy of Medical science | Rao F.,Guangdong Cardiovascular Institute and Guangdong Academy of Medical science | Kuang S.-J.,Guangdong Cardiovascular Institute and Guangdong Academy of Medical science | Wu S.-L.,Guangdong Cardiovascular Institute and Guangdong Academy of Medical science | And 8 more authors.
Clinical and Experimental Pharmacology and Physiology | Year: 2011

It has been reported that allitridi, an active compound extracted from garlic, has many cardiovascular effects. However, it remains unknown whether allitridi affects major repolarization currents, such as the transient outward K+ current (Ito), ultrarapid delayed rectifier K+ current (IKur) and the L-type Ca2+current (ICa), in human atrial myocytes. In the present study, we investigated the effects of allitridi on Ito, IKur, ICa and the action potential in human isolated atrial myocytes using the whole-cell patch recording technique. Allitridi reversibly inhibited Ito, but not IKur and ICa, in human atrial myocytes. These effects of allitridi on Ito were concentration dependent (IC50=44.9μmol/L). Inactivation of Ito was accelerated and the voltage-dependent inactivation potential was shifted towards the negative direction. Allitridi (30μmol/L) significantly prolonged action potential duration in human atrial myocytes. The results of the present study indicate that allitridi inhibits Ito, but not IKur and ICa, and prolongs the action potential duration in human atrial myocytes. © 2011 The Authors. Clinical and Experimental Pharmacology and Physiology © 2011 Blackwell Publishing Asia Pty Ltd.

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