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Tong Y.,U.S. Center for Disease Control and Prevention | Tong Y.,Huazhong University of Science and Technology | Zhan F.,U.S. Center for Disease Control and Prevention | Han J.,Guang Dong Medical College FuTian Hospital | And 13 more authors.
Journal of the Neurological Sciences | Year: 2012

Recent genome-wide association studies (GWAS) have identified two key SNPs (rs11833579 and rs12425791) on chromosome 12p13 that were significantly associated with stroke in Caucasians. However, the validity of the association has remained controversial. We performed genetic association analyses in a very unique population which has 60% European ancestry and 40% East Asian ancestry. No significant association between these two SNPs and ischemic stroke was detected in this Chinese Uyghur population. © 2012 Elsevier B.V. All rights reserved. Source


Han J.,Guang Dong Medical College FuTian Hospital | Li H.,Guang Dong Medical College FuTian Hospital | Wu D.,Guang Dong Medical College FuTian Hospital | Zeng N.,Guang Dong Medical College FuTian Hospital | And 5 more authors.
Annals of Human Biology | Year: 2016

Background: The association between the platelet-derived growth factor D (PDGFD) gene and atherosclerosis has been widely proven, whereas the relationship between the PDGFD gene and ischaemic stroke remains unconfirmed.Aim: A case-control study was performed to further evaluate the association of the C → G mutation of rs7950273 in the PDGFD gene with ischaemic stroke (IS) in a Chinese Han population.Subjects and methods: This study recruited 3033 cases and 2807 controls from general hospitals in the southern, central and northern areas of China. The MGB probe and Taqman 7900HT Sequence Detection System were applied for genotyping.Results: Genotype was not significantly associated with ischaemic stroke in total. After adjustment for gender, age, BMI, hypertension, diabetes mellitus and smoking, the CG and GG genotypes were still not associated with ischaemic stroke (p = 0.892 and p = 0.582 for CG and GG, respectively).Conclusion: This study suggests that the polymorphism of rs7950273 in the PDGFD gene is not associated with ischaemic stroke in the Chinese Han population. Further studies on the gene-gene and gene-environment interactions for the PDGFD gene and ischaemic stroke are needed. © 2015 Taylor & Francis. Source

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