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Beijing, China

Baghdadi Y.M.K.,Mayo Medical School | Larson A.N.,Mayo Medical School | Cui Q.,Guang An Men Hospital | Sebastian A.S.,Mayo Medical School | And 2 more authors.
Spine | Year: 2014

STUDY DESIGN.: Retrospective matched-cohort analysis. OBJECTIVE.: To evaluate the change in radiographical parameters in patients undergoing interbody fusion and posterior instrumentation compared with posterior spine fusion (PSF) alone for degenerative scoliosis. SUMMARY OF BACKGROUND DATA.: Little is known about the effect of lateral interbody fusion (LIF) on sagittal plane correction in the setting of degenerative scoliosis. We performed a retrospective study to investigate these changes compared with PSF. METHODS.: Between 1997 and 2011, 33 patients had LIF at 181 levels between T8 and L5 vertebrae for the treatment of degenerative scoliosis (mean; 5 ± 2 levels). Of those, 23 patients had additional anterior lumbar interbody fusion (ALIF) at 37 levels between L4 and S1 vertebrae (mean; 1.6 ± 0.5 levels). A 1:1 matched control of patients who underwent PSF was performed. Patients were matched by age, sex, and diagnosis. Clinical and radiographical data were collected and compared between the matched cohorts. RESULTS.: Lumbar lordosis (LL) was significantly restored in the LIF ± ALIF compared with PSF cohort (44 ± 14 vs. 36 ± 15 , P = 0.02). The segmental LL over the 102 LIF levels significantly improved from 12 ± 10 to 21 ± 13 postoperatively (P < 0.0001). However, the change over the 37 ALIF levels was not significant (from 30 ± 15 to 29 ± 9 , P = 0.8). Sagittal plane alignment was improved in the LIF ± ALIF compared with PSF cohort and trended toward but did not reach significance (3.8 ± 3.2 cm vs. 6.2 ± 5.7 cm, P = 0.09). Sacral slope was significantly higher in the LIF ± ALIF compared with PSF cohort (33 ± 11 vs. 28 ± 10 , P = 0.03). Pelvic tilt was lower in the LIF ± ALIF compared with PSF cohort and trended toward but did not reach significance (22 ± 10 vs. 26 ± 10 , P = 0.08). CONCLUSION.: LL and sacral slope had mildly but statistically improved in the interbody fusion cohort compared with PSF cohort. Sagittal alignment and pelvic tilt trended toward but did not reach statistical significance. Segmental LL was improved at LIF levels more than at ALIF levels.Level of Evidence: 3 © 2014 Lippincott Williams and Wilkins. Source

Shu Z.,Tsinghua University | Xiaochen L.,Tsinghua University | Chuyun D.,Tsinghua University | Chuyun D.,National University of Defense Technology | And 6 more authors.
Journal of Fluorescence | Year: 2014

Cytosolic pH changes in single thymocytes in the early stages of apoptosis were examined with spectral-crosstalk-improved three-channel real-time fluorescence imaging. Spectral crosstalk was greatly reduced by this improved image processing method. Compared with normal thymocytes, the improved image processing method showed that the cytosolic pH value of thymocytes undergoing apoptosis was lower. A slight diversity in the intracellular pH values of samples subjected to different drug treatments was also observed. This new image processing method is beneficial to the application of the three-channel real-time fluorescence imaging to biological processes. © 2014 Springer Science+Business Media New York. Source

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