Kānpur, India
Kānpur, India

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Jain R.,GSVM Medical College
Journal, Indian Academy of Clinical Medicine | Year: 2010

Objectives: To study, the high sensitivity C-reactive protein (hsCRP) level in Indian patients with stroke and its subtypes, to evaluate whether hsCRP levels in stroke correlate with other risk factors, and also to evaluate the hsCRP level as a prognostic marker in cases of different types of stroke. Material and methods: A prospective study of 40 patients presenting with a history of focal neurological deficit of acute onset in the form of hemiparesis, hemianaesthesia, or having evidence of presence of ischaemic or haemorrhagic infarct in CT scan of brain was done. In all patients hsCRP levels were measured within 72 hours of presentation. Results: Most of the patients (65%) were in the age group of 50 - 70 years. Left-sided hemiparesis with altered sensorium with facial palsy was the most common presenting symptom. hsCRP levels were found to be increased in stroke patients and on comparison with controls, the values were found to be significant (p < 0.001). Also, the values were found to be more in haemorrhagic than ischaemic stroke. No significant correlation was seen with other risk factors like diabetes, dyslipidaemia. It was also seen that patient with low GCS score had high levels of hsCRP in both types of stroke. Mean hsCRP level was 14.8 ± 6.2 in non-survivors of haemorrhagic and 10.7 ± 5.4 in ischaemic stroke. These values were found to be statistically significant (p < 0.001). Conclusion: From this study we concluded that hsCRP level is increased in cases of stroke - ischaemic as well as haemorrhagic, suggesting an inflammatory response in acute stroke. Furthermore, the increased levels correlated with larger infarct and bleed, severe neurological deficit and worse outcome.


Omhare A.,GSVM Medical College | Singh S.K.,Mlb Medical College | Nigam J.S.,Saraswathi Institute of Medical science | Sharma A.,Ddu Hospital
Pathology Research International | Year: 2014

Background. FNAC is a useful method for evaluating suspicious salivary glands lesions due to its low cost, minimum morbidity, rapid turnaround time, high specificity, and sensitivity. Aim. To knowthe frequency of the salivary gland lesions and cytohistological correlation in the Jhansi region, Uttar Pradesh, India. Material and Methods. In present study 124 cases were included and cytohistological correlation was made in 86 cases only. FNA was performed by using a 23/24-gauge needle without local anaesthesia. Air dried and 95% ethyl alcohol fixed wet smears were stained with Giemsa stain and Papanicolaou stain, respectively. Paraffin embedded tissue sections were stained with Haematoxylin and Eosin. Results. Parotid gland was the most commonly involved salivary gland. The commonest age group was 20 to 29 years, 30 to 39 years, and 60 to 69 years for nonneoplastic lesions, benign tumours, and malignant tumours, respectively.The overall male to female ratio was 1.17 : 1.The diagnostic accuracy of FNAC was 100%, 93.3%, and 88.2% for nonneoplastic lesions, benign tumours, and malignant tumours, respectively. Conclusion. The high accuracy, sensitivity, and specificity of FNAC confirmthat preoperative cytology is a useful, quick, reliable diagnostic technique for rapid diagnosis and suitable for developing countries. Copyright © 2014 Anita Omhare et al.


Kala C.,P.A. College | Agarwal A.,P.A. College | Kala S.,Gsvm Medical College
Journal of Cytology | Year: 2011

Rosai-Dorfman disease, that is, sinus histiocytosis with massive lymphadenopathy is a benign systemic proliferative disorder of histiocytes. The typical clinical presentation of the disease includes bilateral painless massive lymphadenopathy, fever and polyclonal hypergammaglobulinemia. Extranodal involvement is present in only a few cases and skin lesions are the most common form of extranodal disease. However, purely cutaneous Rosai-Dorfman disease is uncommon. In this study, we describe a 10-year-old child presenting with bilateral ocular involvement.


Singh A.,All India Institute of Medical Sciences | Vajpeyi I.,GSVM Medical College
Neurology India | Year: 2013

Background: Managing post meningitis hydrocephalus in children is a herculean task for the treating pediatric surgeon or neurosurgeon because of the morbidity associated with the disease per se and the complications of shunt surgery. By this study, the effectiveness of lumboperitoneal (LP) shunt and ventriculoperitoneal (VP) shunt in cases of post meningitis communicating hydrocephalus was assessed in children. Materials and Methods: This was a retrospective analysis of the records of children admitted in our institute between December 2005 and March 2008. Only children with post meningitis communicating hydrocephalus who underwent either LP or VP with a minimum follow-up period of 36 months were included in the study. Children with non-communicating hydrocephalus or hydrocephalus due to another etiology were excluded. Investigations were included plain brain computed tomography scan, air encephalography and X-ray skull. Medium pressure Chabbra shunt with slit valves was used in all cases of VP and LP shunt. A comparative analysis of the outcome was carried out between the two groups. Results: There were 66 males and 24 females (M: F 2.7:1. The average age at presentation was 40.3 months. LP shunt was performed in 37 while VP shunt in 53 cases Complication rate in the LP and VP shunt was 15% and 29% respectively with non-obstructed complications higher in VP group when compared to LP group. Obstructed complication rate was similar in both groups. Conclusion: Due to less morbidity and ease of placement, LP shunt can be an alternative to VP shunt in cases of communicating hydrocephalus in children, which has more non-obstructed complication rates as compared to LP shunt.


Kalra N.K.,GSVM Medical College | Verma A.,GSVM Medical College | Agarwal A.,GSVM Medical College | Pandey H.D.,GSVM Medical College
Journal of Anaesthesiology Clinical Pharmacology | Year: 2011

Background: Both magnesium and clonidine are known to inhibit catecholamine and vasopressin release and attenuate hemodynamic response to pneumoperitoneum. This randomized, double blinded, placebo controlled study has been designed to assess which agent attenuates hemodynamic stress response to pneumoperitoneum better. Materials and Methods: 120 patients undergoing elective laparoscopic cholecystectomy were randomized into 4 groups of 30 each. Group K patients received 50 ml normal saline over a period of 15 min after induction and before pneumoperitoneum, group M patients received 50 mg/kg of magnesium sulfate in normal saline (total volume 50 ml) over same time duration. Similarly group C1 patients received 1 μg/kg clonidine and group C2 1.5 μg/kg clonidine respectively in normal saline (total volume 50 ml). Blood pressure and heart rate were recorded before induction (baseline value), at the end of infusions and every 5 min after pneumoperitoneum. Statistical Analysis: Paired t test was used for intra-group comparison and ANOVA for inter-group comparison. Results: Systolic blood pressure was significantly higher in control group as compared to all other groups during pneumoperitoneum. On comparing patients in group M and group C1, no significant difference in systolic BP was found at any time interval. Patients in group C2 showed best control of systolic BP. As compared to group M and group C1, BP was significantly lower at 10, 30 and 40 min post pneumoperitoneum. No significant episodes of hypotension were found in any of the groups. Extubation time and time to response to verbal command like eye opening was significantly longer in group M as compared to other groups. Conclusion: Administration of magnesium sulfate or clonidine attenuates hemodynamic response to pneumoperitoneum. Although magnesium sulfate 50 mg/kg produces hemodynamic stability comparable to clonidine 1 μg/kg, clonidine in doses of 1.5μg/kg blunts the hemodynamic response to pneumoperitoneum more effectively.


Amit S.,GSVM Medical College
BMJ case reports | Year: 2011

Ependymoblastoma is a rare, highly malignant brain tumour considered by most to be a subtype of primitive neuroectodermal tumour manifesting in young children. The authors present an unusual case of ependymoblastoma occurring in an 18-year-old female, one of the oldest patients reported with this tumour. The crush smears were highly cellular comprising singly scattered small, round immature cells with fine granular chromatin. The paraffin sections showed a tumour composed of uniform, small-sized, primitive cells forming well defined multi-layered rosettes with prominent mitoses. The tumour cells exhibited diffuse Vimentin and focal glial fibrillary acidic protein reactivity. A few cells showed S-100 reactivity. The patient underwent radiotherapy following complete tumour debulking but, succumbed to the disease within 2 months of diagnosis.


Behal R.,CSJM University | Jain R.,GSVM Medical College | Behal K.K.,CSJM University | Dhole T.N.,Sanjay Gandhi Post Graduate Institute of Medical Sciences
Epidemiology and Infection | Year: 2010

This study aimed to determine the relationship between hepatitis C virus (HCV) infection and ABO/Rhesus blood groups, age and sex. A total of 20 000 patients who came to donate blood in the blood bank of GSVM Medical College, Kanpur were enrolled in the study. Demographic data recorded for each patient included age, sex and blood group. Blood samples were tested for anti-HCV antibodies and ABO/Rhesus blood group antigen typing was performed. The overall positive rate of anti-HCV was 034%. We found that seropositivity for HCV increased with age. Anti-HCV antibodies were detected in 1/765 women (013%), compared to 67/19 235 men (035%). Seroprevalence of HCV was found to be higher in blood group O individuals (042%) and lowest in blood group AB individuals (004%). The results of this study demonstrate that that HCV infection may not be related to age and sex but the possible association of blood group antigens with HCV infection cannot be ruled out. Copyright © 2009 Cambridge University Press.


Amit S.,GSVM Medical College
BMJ case reports | Year: 2012

Follicular lymphomas (FL) are among the most common non-Hodgkin's lymphoma (NHL) in adults. However, they are rare in children making up less than 3% of paediatric NHL cases. They occur most commonly in the head and neck region, lymph nodes or tonsils, with occasional extra-nodal occurrences. Distinction of FL from potentially clonal but, reactive follicular hyperplasia is important. We report a case of a 6-year-old male child presenting with night stridor since 6 months. Clinical examination revealed asymmetrical enlargement of the left tonsil. Routine left tonsillectomy was performed and the specimen was sent for histopathological examination. Diagnosis of follicular lymphoma was made on histopathological examination and further confirmed by immunohistochemistry.


Garg A.,GSVM Medical College | Garg J.,GSVM Medical College | Upadhyay G.C.,GSVM Medical College | Agarwal A.,GSVM Medical College | Bhattacharjee A.,Assam University
Antimicrobial Agents and Chemotherapy | Year: 2015

Recently, bioMérieux, France, introduced the Rapidec Carba NP test kit for rapid detection of carbapenemase-producing Gram-negative bacteria. This kit was evaluated in this study, and we report sensitivity, specificity, and positive and negative predictive values of 92.6%, 96.2%, 95.83%, and 92.6%, respectively. The test was easy to perform and interpret and relatively inexpensive ($5/Rs 300 per test) and provides a practical solution for early detection of carbapenemase-producing, multidrug-resistant Gram-negative bacteria. Copyright © 2015, American Society for Microbiology. All Rights Reserved.


Amit S.,GSVM Medical College
BMJ case reports | Year: 2012

Tumoural calcinosis (TC) is a benign gradually developing disorder that can occur in a variety of clinical settings, characterised by subcutaneous deposition of calcium phosphate with or without giant cell reaction. We describe a case of 11-year-old girl presenting with recurrent hard swellings in the vicinity of shoulder and hip joints associated with elevated serum phosphate and normal serum calcium levels. TC has been mainly reported from Africa, with very few cases reported from India. After the diagnosis of hyperphosphatemic TC was established, the patient was treated with oral sevelamer and is under constant follow-up to detect recurrence, if any. The present case highlights the fact that although an uncommon lesion, TC must be considered in the differential diagnosis of subcutaneous hard lump in the vicinity of a joint.

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