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Kānpur, India

Garg A.,Gsvm Medical College | Garg J.,Gsvm Medical College | Upadhyay G.C.,Gsvm Medical College | Agarwal A.,Gsvm Medical College | Bhattacharjee A.,Assam University
Antimicrobial Agents and Chemotherapy | Year: 2015

Recently, bioMérieux, France, introduced the Rapidec Carba NP test kit for rapid detection of carbapenemase-producing Gram-negative bacteria. This kit was evaluated in this study, and we report sensitivity, specificity, and positive and negative predictive values of 92.6%, 96.2%, 95.83%, and 92.6%, respectively. The test was easy to perform and interpret and relatively inexpensive ($5/Rs 300 per test) and provides a practical solution for early detection of carbapenemase-producing, multidrug-resistant Gram-negative bacteria. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Omhare A.,Gsvm Medical College | Singh S.K.,Mlb Medical College | Nigam J.S.,Saraswathi Institute of Medical science | Sharma A.,D.D.U. Hospital
Pathology Research International | Year: 2014

Background. FNAC is a useful method for evaluating suspicious salivary glands lesions due to its low cost, minimum morbidity, rapid turnaround time, high specificity, and sensitivity. Aim. To knowthe frequency of the salivary gland lesions and cytohistological correlation in the Jhansi region, Uttar Pradesh, India. Material and Methods. In present study 124 cases were included and cytohistological correlation was made in 86 cases only. FNA was performed by using a 23/24-gauge needle without local anaesthesia. Air dried and 95% ethyl alcohol fixed wet smears were stained with Giemsa stain and Papanicolaou stain, respectively. Paraffin embedded tissue sections were stained with Haematoxylin and Eosin. Results. Parotid gland was the most commonly involved salivary gland. The commonest age group was 20 to 29 years, 30 to 39 years, and 60 to 69 years for nonneoplastic lesions, benign tumours, and malignant tumours, respectively.The overall male to female ratio was 1.17 : 1.The diagnostic accuracy of FNAC was 100%, 93.3%, and 88.2% for nonneoplastic lesions, benign tumours, and malignant tumours, respectively. Conclusion. The high accuracy, sensitivity, and specificity of FNAC confirmthat preoperative cytology is a useful, quick, reliable diagnostic technique for rapid diagnosis and suitable for developing countries. Copyright © 2014 Anita Omhare et al.

Jain R.,Gsvm Medical College
Journal, Indian Academy of Clinical Medicine | Year: 2010

Objectives: To study, the high sensitivity C-reactive protein (hsCRP) level in Indian patients with stroke and its subtypes, to evaluate whether hsCRP levels in stroke correlate with other risk factors, and also to evaluate the hsCRP level as a prognostic marker in cases of different types of stroke. Material and methods: A prospective study of 40 patients presenting with a history of focal neurological deficit of acute onset in the form of hemiparesis, hemianaesthesia, or having evidence of presence of ischaemic or haemorrhagic infarct in CT scan of brain was done. In all patients hsCRP levels were measured within 72 hours of presentation. Results: Most of the patients (65%) were in the age group of 50 - 70 years. Left-sided hemiparesis with altered sensorium with facial palsy was the most common presenting symptom. hsCRP levels were found to be increased in stroke patients and on comparison with controls, the values were found to be significant (p < 0.001). Also, the values were found to be more in haemorrhagic than ischaemic stroke. No significant correlation was seen with other risk factors like diabetes, dyslipidaemia. It was also seen that patient with low GCS score had high levels of hsCRP in both types of stroke. Mean hsCRP level was 14.8 ± 6.2 in non-survivors of haemorrhagic and 10.7 ± 5.4 in ischaemic stroke. These values were found to be statistically significant (p < 0.001). Conclusion: From this study we concluded that hsCRP level is increased in cases of stroke - ischaemic as well as haemorrhagic, suggesting an inflammatory response in acute stroke. Furthermore, the increased levels correlated with larger infarct and bleed, severe neurological deficit and worse outcome.

Kala C.,P.A. College | Agarwal A.,P.A. College | Kala S.,Gsvm Medical College
Journal of Cytology | Year: 2011

Rosai-Dorfman disease, that is, sinus histiocytosis with massive lymphadenopathy is a benign systemic proliferative disorder of histiocytes. The typical clinical presentation of the disease includes bilateral painless massive lymphadenopathy, fever and polyclonal hypergammaglobulinemia. Extranodal involvement is present in only a few cases and skin lesions are the most common form of extranodal disease. However, purely cutaneous Rosai-Dorfman disease is uncommon. In this study, we describe a 10-year-old child presenting with bilateral ocular involvement.

Amit S.,Gsvm Medical College
BMJ case reports | Year: 2012

Follicular lymphomas (FL) are among the most common non-Hodgkin's lymphoma (NHL) in adults. However, they are rare in children making up less than 3% of paediatric NHL cases. They occur most commonly in the head and neck region, lymph nodes or tonsils, with occasional extra-nodal occurrences. Distinction of FL from potentially clonal but, reactive follicular hyperplasia is important. We report a case of a 6-year-old male child presenting with night stridor since 6 months. Clinical examination revealed asymmetrical enlargement of the left tonsil. Routine left tonsillectomy was performed and the specimen was sent for histopathological examination. Diagnosis of follicular lymphoma was made on histopathological examination and further confirmed by immunohistochemistry.

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