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van den Ban S.,GSK Global Manufacturing and Supply | Goodwin D.J.,Research Frontiers
Powder Technology | Year: 2016

Control over batch fluid bed drying processes is important to assure product of uniform moisture content as the level of residual moisture can impact further processing and final product performance and stability. Entrainment during batch fluidised bed drying can potentially result in non-uniformity of the product moisture content and impact reliability of the process endpoint. A two stage inlet air flow batch drying process was defined to minimise the impact of entrainment on product uniformity. The two stage batch fluid bed drying process reduced the level of entrainment observed. This enables the implementation of a relatively straightforward differential temperature technique based on a temperature sensor only to reliably indicate drying endpoint. © 2016 Elsevier B.V.

Pitt K.G.,GSK Global Manufacturing and Supply | Webber R.J.,GSK Global Manufacturing and Supply | Hill K.A.,GSK Global Manufacturing and Supply | Dey D.,Gamlen Tableting Ltd | Gamlen M.J.,Gamlen Tableting Ltd
Powder Technology | Year: 2013

Small scale compaction studies which utilise equipment representative of commercial scale tablet presses can be used to develop process understanding of pharmaceutical formulations using minimal quantities of material. In this study the scalability of compressibility (solid fraction vs. compaction pressure), tabletability (tensile strength vs. compaction pressure), compactibility (tensile strength vs. solid fraction) and ejection shear stress was examined over an eight-fold range in tablet size. Tablets of two representative commercially manufactured formulations were compressed and compared using a small scale compaction press and large scale industrial press. Different tablet sizes and shapes were produced from the two types of press. One formulation was manufactured by direction compression and the other by wet granulation. Generally, good agreement was found across the scales for all the measures assessed. In addition, the measurement of ejection shear stress data on the small scale was able to accurately predict tablet failure on commercial rotary presses. © 2013 Elsevier B.V. All rights reserved.

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