Khargon, India
Khargon, India

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Rokade Y.,Psgvpms Institute Of Pharmacy | Dongare N.,Gry Institute Of Pharmacy
Rasayan Journal of Chemistry | Year: 2010

Azetidinone derivatives were synthesized from β-naphthol in two steps. First the Schiff's bases were prepared by reacting the hydrazine of a naphthalene derivative with different aromatic aldehydes.Cyclocondensation of the Schiff's bases with chloroacetyl chloride in the presence of triethylamine resulted in the formation of corresponding azetidinone analogues. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR, and Mass spectroscopic analysis The in vitro antibacterial and antifungal activity of compound have been evaluated by paper disc diffusion method. © 2010 RASĀYAN. All rights reserved.


Ajay R.,Siksha ‘O’ Anusandhan University | Kar D.M.,Siksha ‘O’ Anusandhan University | Makkar Renu R.,GRY Institute of Pharmacy
International Journal of Drug Development and Research | Year: 2013

Natural products are used as traditional medicines from ancient times. From ancient times human beings depended on plants for their food and health purpose. A wide range of plants posses medicinal properties, different parts of plants such as root, stem, flower, fruit, or whole plants are used to cure various health calamities. But the infectious diseases caused by microbes remains a major confront for science even today. It is necessary to have ideal anti-microbial products from plant products because they are considered safer and economic. One such medicinal plant species is Ipomoea reniformis, which belongs to convolvulaceae family and Lamiidae subclass. Its antimicrobial activity was evaluated with aqueous, benzene, ethyl acetate, chloroform and ethanolic extract. The investigation was carried out against various gram positive and gram negative bacterial strains (Escherichia coli NCIM 2109; Staphylococcus aureus NCIM 2079, Pseudomonas aeruginosa NCIM 2036; Bacillus subtilis NCIM 2250). Antifungal activity was carried on (Aspergillus niger NCIM 545). Well diffusion method was employed for the detection of antimicrobial activity. Streptomycin and Amphoterecin B were used as standard. The aqueous extract exhibited activity against Staphylococcus aureus, while the chloroform & ethanolic extract elucidated antifungal activity against Aspergillus niger. © 2013 By IYPF All rights reserved.


Karpillai M.,Gry Institute Of Pharmacy | Dhangar S.,Gry Institute Of Pharmacy
Research Journal of Pharmacy and Technology | Year: 2011

A reversed phase HPLC method is developed for the determination of glipizide in pharmaceutical dosage form. Chromatography was carried out on an inertsil C18 column using a mixture of methanol and phosphate buffer (pH 3.4) (55:45 v/v) as the mobile phase at a flow rate of 1ml/min. Detection was carried out at 225nm. The retention time of the drug was 7.098min. The method produced linear responses in the concentration range of 15-75 μg/ml of Glipizide. The method was found to be applicable for the determination of the drug in tablets. © RJPT All right reserved.


Nayak P.,GRY Institute of Pharmacy | Kar D.M.,GRY Institute of Pharmacy | Nayak S.,Siksha ‘O’ Anusandhan University
Journal of Applied Pharmaceutical Science | Year: 2014

The plant Hyptis is an effective medicinal herb and a well known medicinal plant in herbal world. The present study was aimed to investigate the α-amylase inhibition and antioxidant activities of chloroform fraction of H. suaveolens. Chloroform fraction of H. suaveolens was screened for a-amylase inhibition activity by 3, 5-dinitrosalicylic acid (DNSA) method respectively. and antioxidant activity was evaluated by 1,1-diphenyl-2-picryl-hydrazile (DPPH) free radical scavenging, Super oxide radical Scavenging, nitric oxide (NO) radical scavenging, and 2.2'-azinobis-3-ethylbenzothiazole-6-sulfonic acid (ABTS) radical scavenging assays. The chloroform fraction of H. suaveolens showed effective α-amylase inhibition activity (IC50 57.34μg/ml). Chloroform fraction demonstrated significant antioxidant activity in all the in vitro antioxidant models. Moreover, the chloroform fraction was found to be extremely effective in scavenging DPPH (IC50 57.51 μg/ml) while compared to super oxide (IC50 61.36 μg/ml), NO (IC5076.3 μg/ml) and ABTS radical (IC50 93.16 μg/ml) scavenging activity. In conclusion, from the results of present study it is established that antioxidant and alphaamylase inhibitory activity of chloroform fraction of H. suaveolens may contribute in its earlier observed antidiabetic potential. © 2014 Nayak and Kar.


Karpillai M.,Gry Institute Of Pharmacy | Dhangar S.,Gry Institute Of Pharmacy
Research Journal of Pharmacy and Technology | Year: 2011

A reversed phase HPLC method is developed for the determination of citalopram in pharmaceutical dosage form. Chromatography was carried out on an inertsil C18 column using a mixture of methanol and phosphate buffer (pH 3.4) and acetonitrile (55:40:5 v/v/v) as the mobile phase at a flow rate of 1.35ml/min. Detection was carried out at 254nm. The retention time of the drug was 3.741min.The method produced linear responses in the concentration range of 10- 50 μg/ml of Citalopram. The method was found to be applicable for the determination of the drug in tablets. © RJPT All right reserved.


Nayak S.P.,GRY Institute of Pharmacy | Pillai S.,GRY Institute of Pharmacy
Research Journal of Pharmacy and Technology | Year: 2011

Two simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of Amlodipine Besylate and Perindopril Erbumine in tablet dosage form have been developed. First method employs formation and solving of simultaneous equation using 237 nm and 206 nm as two analytical wavelengths for both drugs in methanol. The second method is Q value analysis based on measurement of absorptivity at 227 nm (as an iso-absorptive point) and 237 nm. Beer's law obeyed in concentration range of 5-40 μg/ ml and 15-60 μg/ ml for Amlodipine and perindopril respectively. Recovery studies was found close to100 % for Amlodipine Besylate and Perindopril Erbumine for both the methods. The proposed method is recommended for routine analysis of both the drugs in combined dosage form. © RJPT All right reserved.


Verma R.,Gry Institute Of Pharmacy | Gangrade T.,Gry Institute Of Pharmacy | Punasiya R.,Gry Institute Of Pharmacy | Ghulaxe C.,Gry Institute Of Pharmacy
Pharmacognosy Reviews | Year: 2014

Wild grown European blackberry Rubus fruticosus) plants are widespread in different parts of northern countries and have been extensively used in herbal medicine. The result show that European blackberry plants are used for herbal medicinal purpose such as antimicrobial, anticancer, antidysentery, antidiabetic, antidiarrheal, and also good antioxidant. Blackberry plant (R. fruticosus) contains tannins, gallic acid, villosin, and iron; fruit contains vitamin C, niacin (nicotinic acid), pectin, sugars, and anthocyanins and also contains of berries albumin, citric acid, malic acid, and pectin. Some selected physicochemical characteristics such as berry weight, protein, pH, total acidity, soluble solid, reducing sugar, vitamin C, total antioxidant capacity, antimicrobial screening of fruit, leaves, root, and stem of R. fruticosus, and total anthocyanins of four preselected wild grown European blackberry (R. fruticosus) fruits are investigated. Significant differences on most of the chemical content detect among the medicinal use. The highest protein content (2%), the genotypes with the antioxidant activity of standard butylated hydroxyanisole (BHA) studies 85.07%. Different cultivars grown in same location consistently show differences in antioxidant capacity.


Namdev N.,GRY Institute of Pharmacy | Upadhyay S.,GRY Institute of Pharmacy
Research Journal of Pharmacy and Technology | Year: 2016

Recent advances in biotechnology allow the selection and the preparation of novel macromolecular compounds such as peptides, proteins and DNA analogs (produced by Hybridoma cell technology and Recombinant DNA technology) to be used as drugs (e.g., hormones, monoclonal antibodies, vaccines) for therapeutic purposes. Such compounds show powerful and selective therapeutic activity, but unfortunately they must often be dropped at some development stage, because of their high enzymatic susceptibility, short shelf life or unsuitable efficacy after the administration to the patient, owing to immunogenic reactions or poor bioavailability. A number of approaches have been used to overcome these limitations. As these therapeutic proteins and peptides are made available, it will be essential to formulate these drugs into safe and effective delivery systems. Due to its wider applications in pharmaceutical industries, they will replace many existing organic based pharmaceuticals. Now days, many drugs are in the world market, while several hundred are in clinical trials. This article reviews the various problems associated and novel approaches for formulation and development of oral protein and peptide drug delivery systems. © RJPT All right reserved.


PubMed | Gry Institute Of Pharmacy
Type: Journal Article | Journal: Pharmacognosy reviews | Year: 2014

Wild grown European blackberry Rubus fruticosus) plants are widespread in different parts of northern countries and have been extensively used in herbal medicine. The result show that European blackberry plants are used for herbal medicinal purpose such as antimicrobial, anticancer, antidysentery, antidiabetic, antidiarrheal, and also good antioxidant. Blackberry plant (R. fruticosus) contains tannins, gallic acid, villosin, and iron; fruit contains vitamin C, niacin (nicotinic acid), pectin, sugars, and anthocyanins and also contains of berries albumin, citric acid, malic acid, and pectin. Some selected physicochemical characteristics such as berry weight, protein, pH, total acidity, soluble solid, reducing sugar, vitamin C, total antioxidant capacity, antimicrobial screening of fruit, leaves, root, and stem of R. fruticosus, and total anthocyanins of four preselected wild grown European blackberry (R. fruticosus) fruits are investigated. Significant differences on most of the chemical content detect among the medicinal use. The highest protein content (2%), the genotypes with the antioxidant activity of standard butylated hydroxyanisole (BHA) studies 85.07%. Different cultivars grown in same location consistently show differences in antioxidant capacity.


PubMed | GRY Institute of Pharmacy
Type: Comparative Study | Journal: Indian journal of medical sciences | Year: 2012

The plant Argemone mexicana is traditionally used as diuretic, anti-inflammatory, antibacterial, antifungal agent, and has wound-healing property. This study was carried out to evaluate the effect of A. mexicana aerial part of the plant (methanolic and aqueous extract p.o.) on duodenal ulceration.The study was carried out on the duodenal ulceration model by using cysteamine hydrochloride. Ranitidine (20 mg/kg) was used as standard drug.Both the extracts of the plant A. mexicana produced a significant activity in cysteamine-induced duodenal ulceration. The aqueous extract at the dose-dependent manner showed the potent activity than methanolic extract.The plant A. mexicana Linn. Increased healing of gastric ulceration and prevented the development of experimentally induced duodenal ulceration in rats.

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