GRY Institute of Pharmacy

Khargon, India

GRY Institute of Pharmacy

Khargon, India
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Golher H.K.,GRY Institute of Pharmacy | Kapse K.,GRY Institute of Pharmacy | Singh S.K.,IPR Units
International Journal of PharmTech Research | Year: 2010

Three simple, accurate, and reproducible spectrophotometric methods have been developed for the simultaneous estimation of Torsemide (TOR) and spironolactone (SPI) in combined tablet dosage form. The methods employed were absorbance ratio, I; first order derivative spectroscopy method, II; and area under curve (AUC) method, III. Torsemide showed absorbance maxima at 288 nm and spironolactone showed at 238 nm in methanol as solvent. Beer's law was obeyed in concentration range of 0-25 mcg ml -1 for both drugs for all proposed three methods. The first developed method makes use absorbance ratio method using 255 nm as isobestic point. The second method is based on first order derivative spectroscopy to overcome spectral interference from other drug, wavelengths 315 nm and 225 nm were selected for the determination of the TOR and SPI respectively. Third method is area under curve method, the sampling wavelengths range selected are 294-290 nm and 240-236 nm with linearity for TOR and SPI respectively. The results of the analysis were validated statistically and recovery studies were carried out as per ICH guidelines.


Nayak P.S.,Siksha ‘O’ Anusandhan University | Kar D.M.,Siksha ‘O’ Anusandhan University | Nayak S.P.,GRY Institute of Pharmacy
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2015

Objective: Phytosterols are group of steroidal alcohol play important roles in structural component in the cell membrane and play a role in membrane stability. There are almost 22 different sterols are found yet and the major phytosterols include ß-sitosterol, campesterol and stigmasterol. The objective of this study was to isolate and characterize the bioactive principles from the chloroform fraction of Argemone Mexicana L. Methods: The isolation was done using column chromatography using gradient elution with different mobile phases. The isolated compound was subjected to spectral analysis. Structure elucidation was carried out on basis of spectral analysis. Results: The chemical investigation of the chloroform fraction of aerial parts of belonging to the family Papaveraceae led to the isolation of stigmasterol. The isolated compounds were characterized using various spectroscopic data as well as chemical studies. Conclusion: From the spectral characteristics, the isolated compound from the chloroform fraction of aerial parts was confirmed to be stigmasterol. This is the first ever report of these stigmasterol compound from the chloroform fraction of aerial parts of Argemone mexicana. © 2015, International Journal of Pharmacy and Pharmaceutical Science. All rights reserved.


Choudhury A.,GRY Institute of Pharmacy | Das S.,GRY Institute of Pharmacy | Kar M.,GRY Institute of Pharmacy
International Journal of PharmTech Research | Year: 2011

The objective of this review is to describe the potentiality of vaginal route and the current status of several intravaginal delivery systems. A number of exhaustive efforts have been made toward the administration of drugs, via alternative routes, that are poorly absorbed after the oral administration. The vagina as a route of drug delivery has been known since ancient times. In recent years, the vaginal route has been rediscovered as a potential route for systemic delivery of peptides and other therapeutically important macromolecules. A great deal of interest has been notice in the design and application of different dosage forms via the vaginal route. Several studies have proven that the vagina is an effective route for drug administration intended mainly for local action, but systemic effects of some drugs also can be attained. The major advantages of this route include accessibility, good blood supply, the ability to bypass first-pass liver metabolism, and permeability to large molecular weight drugs, such as peptides and proteins. This review, therefore, summarizes various vaginal drug delivery systems with an introduction to vaginal physiology and factors affecting drug absorption from the vaginal route.


Choudhury A.,GRY Institute of Pharmacy | Das S.,GRY Institute of Pharmacy | Bahadur S.,GRY Institute of Pharmacy | Saha S.,GRY Institute of Pharmacy | Roy A.,GRY Institute of Pharmacy
Indian Journal of Pharmaceutical Sciences | Year: 2010

Omeprazole pellets containing mucoadhesive tablets were developed by direct punch method. Three mucoadhesive polymers namely hydroxypropylemethylcellulose K4M, sodium carboxy methylcellulose, carbopol-934P and ethyl cellulose were used for preparation of tablets which intended for prolong action may be due to the attachment with intestinal mucosa for relief from active duodenal ulcer. Mucoadhesive tablets were coated with respective polymer and coated with Eudragit L100 to fabricate enteric coated tablets. The prepared tablets were evaluated for different physical parameters and dissolution study were performed in three dissolution mediums like 0.1N hydrochloric acid for 2h, pH 6.5 and pH 7.8 phosphate buffer solution for 12hr. Sodium carboxymethylcellulose showed above 95% release within 10 h where as carbopol-934P showed slow release about 88% to 92% over a period of 12 h. having excellent mucoadhesive strength but ethyl cellulose containing tablets showed less than 65% release. The release mechanism of all formulation was diffusion controlled confirmed from Higuchi′s plot. Thus, the present study concluded that, carbopol-934P containing mucoadhesive tablets of omeprazole pellets can be used for local action in the ulcer disease as well as for oral controlled release drug delivery.


Choudhury A.,GRY Institute of Pharmacy | Das S.,GRY Institute of Pharmacy | Dhangar S.,GRY Institute of Pharmacy | Kapasiya S.,GRY Institute of Pharmacy | Kanango A.,GRY Institute of Pharmacy
International Journal of PharmTech Research | Year: 2010

The purpose of the experimental study was to design a sustained release film formulation of ciprofloxacin hydrochloride for the treatment of periodontal diseases and investigate different experimental parameters to conclude in details about its different characteristics.Films were formulated using different concentration hydroxypropylmethyl cellulose and polyvinyl alcohol. The prepared films were subjected to different evaluation like determination of weight, thickness, surface pH, folding endurance, swelling index, mucoadhesion time, mucoadhesion strength, drug content, in-vitro drug release study, ex-vivo release study and release kinetic behavior. From the results of evaluation it was concluded that all the prepared films having desire flexibility and mucoadhesive properties, along with that they shows good in-vitro and ex-vivo drug release performance. Drug release from the films follows desire sustained release phenomenon as needed in buccoadhesive drug delivery.


Rokade Y.,Psgvpms Institute Of Pharmacy | Dongare N.,Gry Institute Of Pharmacy
Rasayan Journal of Chemistry | Year: 2010

Azetidinone derivatives were synthesized from β-naphthol in two steps. First the Schiff's bases were prepared by reacting the hydrazine of a naphthalene derivative with different aromatic aldehydes.Cyclocondensation of the Schiff's bases with chloroacetyl chloride in the presence of triethylamine resulted in the formation of corresponding azetidinone analogues. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR, and Mass spectroscopic analysis The in vitro antibacterial and antifungal activity of compound have been evaluated by paper disc diffusion method. © 2010 RASĀYAN. All rights reserved.


Karpillai M.,Gry Institute Of Pharmacy | Dhangar S.,Gry Institute Of Pharmacy
Research Journal of Pharmacy and Technology | Year: 2011

A reversed phase HPLC method is developed for the determination of glipizide in pharmaceutical dosage form. Chromatography was carried out on an inertsil C18 column using a mixture of methanol and phosphate buffer (pH 3.4) (55:45 v/v) as the mobile phase at a flow rate of 1ml/min. Detection was carried out at 225nm. The retention time of the drug was 7.098min. The method produced linear responses in the concentration range of 15-75 μg/ml of Glipizide. The method was found to be applicable for the determination of the drug in tablets. © RJPT All right reserved.


Nayak S.P.,GRY Institute of Pharmacy | Pillai S.,GRY Institute of Pharmacy
Research Journal of Pharmacy and Technology | Year: 2011

Two simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of Amlodipine Besylate and Perindopril Erbumine in tablet dosage form have been developed. First method employs formation and solving of simultaneous equation using 237 nm and 206 nm as two analytical wavelengths for both drugs in methanol. The second method is Q value analysis based on measurement of absorptivity at 227 nm (as an iso-absorptive point) and 237 nm. Beer's law obeyed in concentration range of 5-40 μg/ ml and 15-60 μg/ ml for Amlodipine and perindopril respectively. Recovery studies was found close to100 % for Amlodipine Besylate and Perindopril Erbumine for both the methods. The proposed method is recommended for routine analysis of both the drugs in combined dosage form. © RJPT All right reserved.


Verma R.,Gry Institute Of Pharmacy | Gangrade T.,Gry Institute Of Pharmacy | Punasiya R.,Gry Institute Of Pharmacy | Ghulaxe C.,Gry Institute Of Pharmacy
Pharmacognosy Reviews | Year: 2014

Wild grown European blackberry Rubus fruticosus) plants are widespread in different parts of northern countries and have been extensively used in herbal medicine. The result show that European blackberry plants are used for herbal medicinal purpose such as antimicrobial, anticancer, antidysentery, antidiabetic, antidiarrheal, and also good antioxidant. Blackberry plant (R. fruticosus) contains tannins, gallic acid, villosin, and iron; fruit contains vitamin C, niacin (nicotinic acid), pectin, sugars, and anthocyanins and also contains of berries albumin, citric acid, malic acid, and pectin. Some selected physicochemical characteristics such as berry weight, protein, pH, total acidity, soluble solid, reducing sugar, vitamin C, total antioxidant capacity, antimicrobial screening of fruit, leaves, root, and stem of R. fruticosus, and total anthocyanins of four preselected wild grown European blackberry (R. fruticosus) fruits are investigated. Significant differences on most of the chemical content detect among the medicinal use. The highest protein content (2%), the genotypes with the antioxidant activity of standard butylated hydroxyanisole (BHA) studies 85.07%. Different cultivars grown in same location consistently show differences in antioxidant capacity.


Namdev N.,GRY Institute of Pharmacy | Upadhyay S.,GRY Institute of Pharmacy
Research Journal of Pharmacy and Technology | Year: 2016

Recent advances in biotechnology allow the selection and the preparation of novel macromolecular compounds such as peptides, proteins and DNA analogs (produced by Hybridoma cell technology and Recombinant DNA technology) to be used as drugs (e.g., hormones, monoclonal antibodies, vaccines) for therapeutic purposes. Such compounds show powerful and selective therapeutic activity, but unfortunately they must often be dropped at some development stage, because of their high enzymatic susceptibility, short shelf life or unsuitable efficacy after the administration to the patient, owing to immunogenic reactions or poor bioavailability. A number of approaches have been used to overcome these limitations. As these therapeutic proteins and peptides are made available, it will be essential to formulate these drugs into safe and effective delivery systems. Due to its wider applications in pharmaceutical industries, they will replace many existing organic based pharmaceuticals. Now days, many drugs are in the world market, while several hundred are in clinical trials. This article reviews the various problems associated and novel approaches for formulation and development of oral protein and peptide drug delivery systems. © RJPT All right reserved.

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