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Dominguez A.,Grupo Empresarial LABIOFAM | Polanco R.,Grupo Empresarial LABIOFAM | Cossio G.,Institute Informacion Cientifica y Tecnologica | Morejon Y.,Institute Informacion Cientifica y Tecnologica | Riquenes Y.,Grupo Empresarial LABIOFAM
Biotecnologia Aplicada | Year: 2014

The dynamism observed in the area of veterinary vaccinology needs to be monitored by the biopharmaceutical industry, thus, to anticipate the possible changes and take actions that allow it to adapt to the future scenario. On this basis, a study was performed to assess the current status, trends, scientific and technological projections in the production of veterinary vaccines. To this end, a topic search was done, on vaccines for poultry, cattle, pigs, rabbits, horses, fsh and dogs, in the Scopus database from 2008 to 2012 2008-2012 was done and further contextualized to early 2014. It was found that veterinary vaccinology is a booming field, with the highest growth in the year 2011 with 18.05 % compared to 2008. As such, the US and China are leading this issue, having a major scientific interest in protein antigens, adjuvants and viral vaccines produced with conventional technologies. The most attended species are birds, pigs and cattle, the frst species with 15.21 % of all publications. We conclude that the dominance of the classical vaccine production technologies will continue despite the advances in genetic engineering and biotechnology. Vaccines produced with modern technologies seem to be, at least for now, less affordable for the producer, and therefore, impractical. Similarly, the next few years will be very important for the development and registration of new vaccines obtained by DIVA technology and their diagnostic systems.


Dominguez A.,Grupo Empresarial LABIOFAM | Polanco R.,Grupo Empresarial LABIOFAM | Cossio G.,Institute Informacion Cientifica y Tecnologica | Morejon Y.,Institute Informacion Cientifica y Tecnologica | Riquenes Y.,Grupo Empresarial LABIOFAM
Biotecnologia Aplicada | Year: 2014

The dynamism observed in the area of veterinary vaccinology needs to be monitored by the biopharmaceutical industry, thus, to anticipate to the possible changes and take actions that allow it to adapt to the future scenario. On this basis, a study was performed to assess the current status, trends, scientific and technological projections in the production of veterinary vaccines. To this end, a topic search was done on vaccines for poultry, cattle, pigs, rabbits, horses, fish and dogs, in the Scopus database from 2008 to 2012 and further contextualized to early 2014. It was found that veterinary vaccinology is a booming field, with the highest growth in the year 2011 with 18.05 % compared to 2008. As such, the US and China are leading this issue, having a major scientific interest in protein antigens, adjuvants and viral vaccines produced with conventional technologies. The most attended species are birds, pigs and cattle, the first species with 15.21 % of all publications. We conclude that the dominance of the classical vaccine production technologies will continue despite the advances in genetic engineering and biotechnology. Vaccines produced with modern technologies seem to be, at least for now, less affordable for the producer, and therefore impractical. Similarly, the next few years will be very important for the development and registration of new vaccines obtained by DIVA technology and their diagnostic systems.


Diaz-Miranda M.,Grupo Empresarial LABIOFAM | Campos T.,Grupo Empresarial LABIOFAM | Perez J.E.,Grupo Empresarial LABIOFAM | Paneque D.,Grupo Empresarial LABIOFAM
Biotecnologia Aplicada | Year: 2012

Equine Infectious Anemia Virus (EIAV) is the causal agent of equine infectious anemia. Plasma virus RNA levels and the fraction of infected cells are both very low during the chronic stage of EIAV infections, turning the amplification of viral genes into a technically demanding task. In this work, DNA was extracted from the spleen of a chronically infected animal previously immunosuppressed with prednisolone, amplifying by nested PCR and sequencing the segment of the gag gene that codes for the p26 protein. Phylogenetic analysis placed the Cuban strain closest to three Canadian strains. The translated protein sequence exhibits 7 differences with the most related Canadian strain (Can7) and 13 with the Wyoming strain. This is the first report of a partial nucleotide sequence from EIAV in Cuba and the Caribbean.

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