Grupo de Epidemiologia

Medicina, Uruguay

Grupo de Epidemiologia

Medicina, Uruguay
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De Stefani E.,Grupo de Epidemiologia | Deneo-Pellegrini H.,Grupo de Epidemiologia | Boffetta P.,International Agency for Research on Cancer | Aune D.,University of Oslo | And 4 more authors.
Cancer Causes and Control | Year: 2010

Objective In order to explore the role of broader eating patterns in the etiology of prostate cancer, we conducted a principal components analysis among Uruguayan men. Methods The study included 345 newly diagnosed cases of advanced prostate cancer and 690 hospitalized controls. The factor analysis was performed using the control population. Results Factor analysis allowed the extraction of five patterns, labeled as prudent, traditional, substituter, drinker, and Western. Whereas the traditional and Western patterns were directly associated with risk of prostate cancer (OR for high quartile versus the low quartile of the Western diet was 2.35, 95% CI 1.44-3.85, p-value for trend<0.0001), the prudent, drinker, and substituter patterns were not associated with risk of the disease. After adjustment of each pattern for the foods with high loadings, these three patterns did not modify substantially their original ORs. Conclusion The Western and traditional patterns could partially explain the high incidence of advanced prostate cancer in Uruguay, a main producer of beef in the World. © Springer Science+Business Media B.V. 2010.


De Stefani E.,Grupo de Epidemiologia | Ronco A.L.,University Maldonado | Deneo-Pellegrini H.,Grupo de Epidemiologia | Correa P.,Vanderbilt University | And 3 more authors.
Nutrition and Cancer | Year: 2011

In the period 1996-2004, a hospital-based case-control study on diet and adenocarcinoma of the lung in men was conducted in Montevideo, Uruguay. The study included 200 cases and 800 controls, frequency matched on age, residence, and interviewers. Factor analysis (principal components) was used to identify the major food patterns associated with adenocarcinoma. The analysis of food groups led to the identification of 4 patterns, arbitrarily labeled as Western, starchy vegetables, prudent, and milk/coffee. Whereas the Western pattern (OR 1.94, 95% CI 1.08-3.45) and the milk/coffee pattern (OR 2.30, 95% CI 1.35-3.90) were positively associated with risk of adenocarcinoma of the lung, the starchy vegetables (OR 0.49, 95% 0.28-0.86) and prudent patterns (OR 0.54, 95% CI 0.32-0.92) were significantly protective against this malignancy. The results suggests that adenocarcinoma of the lung could be considered a different nosologic entity, compared with the other histologies of lung cancer. © 2011, Crown.

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