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Antoniu S.A.,Grtpopa University Of Medicine And Pharmacy Iasi
Expert Opinion on Investigational Drugs | Year: 2012

This is the annual perspective paper on the discontinued drugs in the field of pulmonary allergy, gastrointestinal, and arthritis conditions. It is part of series of papers discussing drugs discontinued from clinical development in the previous year and presented according to therapeutic indication. Specifically, this paper presents the 23 compounds developed for various inflammatory conditions and 10 pulmonary drugs which were discontinued in 2011. Information for this perspective was derived from a search of the Pharmaprojects database for drugs discontinued after reaching Phase-I III clinical trials. © Informa UK, Ltd.

Antoniu S.A.,Grtpopa University Of Medicine And Pharmacy Iasi
Biomarkers | Year: 2010

In chronic obstructive pulmonary disease (COPD) airways inflammation is associated in more advanced stages with systemic inflammation. COPD-associated systemic inflammation syndrome is defined currently with rather non-specific biomarkers such as C-reactive protein (CRP) but there are also other 'organ-specific' biomarkers such as surfactant protein-D which are still not well characterized but might represent more appropriate and reliable alternatives to the non-specific biomarkers. Inhaled therapies are the mainstay in stable COPD and they were demonstrated to reduce airway inflammation and more recently in the case of inhaled corticosteroids alone or combined with long-acting beta-2 agonists to reduce systemic inflammation as well. This paper focuses on current and potential biomarkers of systemic inflammation in COPD and on the systemic anti-inflammatory effects of inhaled therapies in stable COPD. © 2010 Informa UK Ltd.

Diaconu C.H.,Grtpopa University Of Medicine And Pharmacy Iasi
Revista medico-chirurgicalǎ̌ a Societǎ̌ţii de Medici ş̧i Naturaliş̧ti din Iaş̧i | Year: 2011

Food-drug interactions are increasingly recognized as important clinical events which may change significantly the bioavailability of oral administrated drugs. Grapefruit juice (GFJ) demonstrated multiple interactions with drugs leading to loss of the therapeutic effects or increased side-effects. GFJ decreases pre-systemic metabolism through a) competitive or mechanism-based inhibition of gut wall CYP3A4 isoenzymes and b) P-glycoprotein (P-gp), c) multidrug resistance protein-2 (MRP2) or d) organic anion-transporting polypeptide (OATP) inhibition. Although, GFJ presents high amounts of flavonoids (e.g. naringin, naringenin), furanocoumarins (e.g. 6',7'-dihydroxybergamottin, bergamottin) are the main chemicals involved in the pharmacokinetic interactions. As compounds of GFJ show additive or synergistic effects, all the major furanocoumarins are necessary for the maximal inhibitory effect. Also, related citrus fruits (sweeties, pummelo and sour orange) or various plants containing furanocoumarins may present pharmacological interactions, yet to be discovered.

Labusca L.,Grtpopa University Of Medicine And Pharmacy Iasi | Zugun-Eloae F.,Grtpopa University Of Medicine And Pharmacy Iasi | Nacu V.,Stefan Cel Mare University of Suceava | Mashayekhi K.,BioTalentum Ltd
Recent Patents on Regenerative Medicine | Year: 2013

The multifunctional "adipose organ" is involved in thermal, metabolic and hormonal body balance. The high content of adult mesenchymal stem cells is recommending adipose tissue as an appealing reservoir of cells to be used in regenerative therapies. Adipose derived stem cells (ASC) have remarkable proliferative and differentiation potential. This paper reviews current scientific knowledge regarding the importance of ASC in the context of regenerative medicine. Recent patents and applications describing methods of human ASC isolation and their use for regenerating musculoskeletal tissues (bone, cartilage, intervertebral disc, tendon and skeletal muscle) are discussed. Several challenges related to cell based product development are presented. Future directions as well as the importance of new genomic technologies in cell source selection and design of patient - oriented treatment algorithms, are outlined. © 2013 Bentham Science Publishers.

Petreus T.,Grtpopa University Of Medicine And Pharmacy Iasi | Stoica B.A.,Grtpopa University Of Medicine And Pharmacy Iasi | Petreus O.,Petru Poni Institute of Macromolecular Chemistry | Goriuc A.,Grtpopa University Of Medicine And Pharmacy Iasi | And 3 more authors.
Journal of Materials Science: Materials in Medicine | Year: 2014

Chemical modification of cellulose by phosphorylation enhances its bioactivity and provides new derivatives and materials with specific end uses. In the present study, cellulose derivatized with phosphorous acid was obtained using the reaction of microcrystalline cellulose with phosphorous acid-urea mixture, in molten state, in comparison with others methods that used different solvents and catalysts. Completely water soluble films with a substitution degree close to one were obtained and characterized by analytical and spectral analysis (FT-IR, 31P NMR), contact angle, metallographic microscopy and atomic force microscopy (AFM). 31P NMR spectra of derivatized cellulose showed a signal at 2.58 ppm (assigned to P-O-C6) while the doublets at 4.99-5.29 and at 7.38 ppm were assigned to P-O-C2 and P-O-C3, respectively; thus, the formation of monosubstituted phosphorous acid esters of cellulose is advocated. Contact angle measurements showed that the work of adhesion is more important in water than in ethylene glycol, for the phosphorous acid derivatized cellulose. The cytocompatibility of this hydrosoluble derivatized cellulose was tested by direct contact and also by indirect assays on normal human dermal fibroblasts and on osteoblast-like cells (human osteosarcoma). Cell growth on phosphorylated cellulose pellicle and the results from viability assays had shown a good cytocompatibility and lack of toxicity. Phosphorous acid derivatized cellulose would offer a promising biomaterial, useful as scaffolds for new biopolymer composites, and subject for further development as an ionic crosslinker. © 2014 Springer Science+Business Media.

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