PubMed | Narayana Nethralaya, Narayana Nethralaya Foundation and b GROW Research Laboratory
Type: Journal Article | Journal: Current eye research | Year: 2016
To assess visual, keratometry, densitometry, and corneal deformation outcomes after accelerated crosslinking (CXL) and its association with gene expression of extracellular matrix proteins.33 eyes underwent accelerated CXL (9 mW/cmCorrected distance visual acuity (CDVA) remained unchanged (p > 0.05). Cylinder (p = 0.0003) and spherical equivalent error (p = 0.02) reduced significantly after CXL. Keratometry and cone location magnitude index (CLMI) were unchanged after CXL (p > 0.05). Corneal densitometry was significantly altered only in the central 0-2 mm region (p = 0.009). A new measure of corneal deformation, named corneal stiffness, was also stable after CXL (p > 0.05). The preoperative level of different proteins did not influence the clinical outcomes described above (p > 0.05).Accelerated CXL appears to be safe and provides biomechanical stability. Keratometry and refraction remained stable after CXL, with significant improvement in cylindrical error. Molecular expression profile of the keratoconic epithelium did not influence the clinical outcomes.