Groupement des Hopitaux Paris Center

Paris, France

Groupement des Hopitaux Paris Center

Paris, France

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Thomas-Schoemann A.,Center Detude Et Of Recours Aux Inhibiteurs Of Langiogenese | Thomas-Schoemann A.,Groupement des Hopitaux Paris Center | Blanchet B.,Center Detude Et Of Recours Aux Inhibiteurs Of Langiogenese | Blanchet B.,Groupement des Hopitaux Paris Center | And 9 more authors.
Critical Reviews in Oncology/Hematology | Year: 2014

Drug interactions are an on-going concern in the treatment of cancer, especially when targeted therapies, such as tyrosine kinase inhibitors (TKI) or mammalian target of rapamycin (mTOR) inhibitors, are being used. The emergence of elderly patients and/or patients with both cancer and other chronic co-morbidities leads to polypharmacy. Therefore, the risk of drug-drug interactions (DDI) becomes a clinically relevant issue, all the more so as TKIs and mTOR inhibitors are essentially metabolised by cytochrome P450 enzymes. These DDIs can result in variability in anticancer drug exposure, thus favouring the selection of resistant cellular clones or the occurrence of toxicity. This review provides a comprehensive overview of DDIs that involve targeted therapies approved by the FDA for the treatment of solid tumours for more than 3 years (sorafenib, sunitinib, erlotinib, gefitinib, imatinib, lapatinib, everolimus, temsirolimus) and medicinal herb or drugs. This review also provides some guidelines to help oncologists and pharmacists in their clinical practice. © 2013 Elsevier Ireland Ltd.


Thomas-Schoemann A.,University of Paris Descartes | Batteux F.,University of Paris Descartes | Alexandre J.,University of Paris Descartes | Alexandre J.,Groupement des Hopitaux Paris Center
OncoImmunology | Year: 2013

The depletion of regulatory T cells (Tregs) is a promising therapeutic strategy to enhance antitumor immune responses.Our recent findings indicate that low doses of arsenic trioxide can delay tumor growth in murine models of colon and breast cancer by depleting Tregs through oxidative and nitrosative bursts. © 2013 Landes Bioscience.


PubMed | Center Detude Et Of Recours Aux Inhibiteurs Of Langiogenese, University of Paris Descartes and Groupement des Hopitaux Paris Center
Type: Journal Article | Journal: Critical reviews in oncology/hematology | Year: 2013

Drug interactions are an on-going concern in the treatment of cancer, especially when targeted therapies, such as tyrosine kinase inhibitors (TKI) or mammalian target of rapamycin (mTOR) inhibitors, are being used. The emergence of elderly patients and/or patients with both cancer and other chronic co-morbidities leads to polypharmacy. Therefore, the risk of drug-drug interactions (DDI) becomes a clinically relevant issue, all the more so as TKIs and mTOR inhibitors are essentially metabolised by cytochrome P450 enzymes. These DDIs can result in variability in anticancer drug exposure, thus favouring the selection of resistant cellular clones or the occurrence of toxicity. This review provides a comprehensive overview of DDIs that involve targeted therapies approved by the FDA for the treatment of solid tumours for more than 3 years (sorafenib, sunitinib, erlotinib, gefitinib, imatinib, lapatinib, everolimus, temsirolimus) and medicinal herb or drugs. This review also provides some guidelines to help oncologists and pharmacists in their clinical practice.

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